FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of Biological Chemistry

• Publication date

  1994-01-31

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.2210/PDB1FKD/PDBPMID 7684380
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Improved calcineurin inhibition by yeast FKBP12-drug complexes. Crystallographic and functional analysis.

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• Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

  1992cited by this paper
• Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex.

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• Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction.

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• Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex.

  1992cited by this paper
• Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

  1992cited by this paper
• Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A.

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• Solution structure of FK506 bound to FKBP‐12

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• FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

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• The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

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• P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody.

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• Chemistry and biology of the immunophilins and their immunosuppressive ligands.

  1991cited by this paper
• Solution structure of the major binding protein for the immunosuppressant FK506

  1991cited by this paper
• Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy

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• FK 506-induced nephrotoxicity in rats.

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  1991cited by this paper
• Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?

  1991cited by this paper
• Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

  1991cited by this paper
• Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution.

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• Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin

  1991cited by this paper
• The NMR structure of cyclosporin A bound to cyclophilin in aqueous solution.

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• Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

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  1984cited by this paper

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  2012cites this paper
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  2011cites this paper
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  2009cites this paper
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