Cell cycle perturbations induced by human herpesvirus 6 infection and their effect on virus replication

In this study, we demonstrate that infection of HSB-2 cells with human herpesvirus 6 (HHV-6) resulted in the accumulation of infected cells in the G2/M phase of the cell cycle. Analysis of various cell-cycle-regulatory proteins indicated that the levels of cyclins A2, B1, and E1 were increased in HHV-6-infected cells, but there was no difference in cyclin D1 levels between mock-infected and HHV-6-infected cells. Our data also showed that inducing G2/M phase arrest in cells infected by HHV-6 provided favorable conditions for viral replication.

• Publication year

  2013

• Venue

  Archives of Virology

• Publication date

  2013-09-08

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00705-013-1826-0PMID 24013234PMCID 7086940
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human herpesvirus 6A infects human embryonic fibroblasts and induces G2/M arrest and cell death

  2012cited by this paper
• Human Herpesvirus 6 Suppresses T Cell Proliferation through Induction of Cell Cycle Arrest in Infected Cells in the G2/M Phase

  2011cited by this paper
• Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV‐6 in post‐infective fatigue syndrome

  2010cited by this paper
• Avian Reovirus Nonstructural Protein p17-Induced G2/M Cell Cycle Arrest and Host Cellular Protein Translation Shutoff Involve Activation of p53-Dependent Pathways

  2010cited by this paper
• Influenza A Virus Replication Induces Cell Cycle Arrest in G0/G1 Phase

  2010cited by this paper
• Viral manipulation of DNA repair and cell cycle checkpoints.

  2009cited by this paper
• G2/M cell cycle arrest in the life cycle of viruses

  2007cited by this paper
• Human Herpesvirus 6A (HHV-6A) and HHV-6B Alter E2F1/Rb Pathways and E2F1 Localization and Cause Cell Cycle Arrest in Infected T Cells

  2007cited by this paper
• Human herpesvirus 6A accelerates AIDS progression in macaques

  2007cited by this paper
• Cell Cycle Perturbations Induced by Infection with the Coronavirus Infectious Bronchitis Virus and Their Effect on Virus Replication

  2006cited by this paper
• Human Herpesvirus‐6‐Specific Interleukin 10‐Producing CD4+ T Cells Suppress the CD4+ T‐Cell Response in Infected Individuals

  2006cited by this paper
• Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway.

  2006cited by this paper
• Human Herpesvirus 6B Induces Cell Cycle Arrest Concomitant with p53 Phosphorylation and Accumulation in T Cells

  2005cited by this paper
• Epstein-Barr Virus Lytic Replication Elicits ATM Checkpoint Signal Transduction While Providing an S-phase-like Cellular Environment*

  2005cited by this paper
• Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy

  2005cited by this paper
• Cell Cycle Arrest in G2/M Promotes Early Steps of Infection by Human Immunodeficiency Virus

  2005cited by this paper
• Intracellular Targeting Signals Contribute to Localization of Coronavirus Spike Proteins near the Virus Assembly Site

  2004cited by this paper
• Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle.

  2004cited by this paper
• Human herpesvirus 6 infection arrests cord blood mononuclear cells in G2 phase of the cell cycle

  2004cited by this paper
• Infection with an Endemic Human Herpesvirus Disrupts Critical Glial Precursor Cell Properties

  2004cited by this paper
• Latent human herpesvirus-6 DNA is sparsely distributed in peripheral blood lymphocytes of healthy adults and patients with lymphocytic disorders

  2004cited by this paper
• The cell cycle, cyclin-dependent kinases, and viral infections: new horizons and unexpected connections.

  2003cited by this paper
• Human Parvovirus B19 Induces Cell Cycle Arrest at G2 Phase with Accumulation of Mitotic Cyclins

  2001cited by this paper
• The Missing Link in Coronavirus Assembly

  2001cited by this paper
• Strategies in subversion: de‐regulation of the mammalian cell cycle by viral gene products

  2001cited by this paper
• The Paramyxovirus Simian Virus 5 V Protein Slows Progression of the Cell Cycle

  2000cited by this paper
• The anaphase-promoting complex: new subunits and regulators.

  1999cited by this paper
• Viruses and the cell cycle.

  1997cited by this paper
• Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

  1995cited by this paper
• Cyclin-dependent regulation of G1 in mammalian fibroblasts.

  1993cited by this paper
• Differentiation between two distinct classes of viruses now classified as human herpesvirus 6.

  1991cited by this paper
• Universal control mechanism regulating onset of M-phase

  1990cited by this paper
• The E1 glycoprotein of an avian coronavirus is targeted to the cis Golgi complex.

  1990cited by this paper
• S phase of the cell cycle.

  1989cited by this paper
• Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus

  1989cited by this paper
• Identification of human herpesvirus-6 as a causal agent for exanthem subitum.

  1988cited by this paper

• Transcriptomic profiling of thymic dysregulation and viral tropism after neonatal roseolovirus infection

  2024cites this paper
• Next-Generation Sequencing Analysis of Cellular Response to Influenza B Virus Infection

  2020cites this paper
• Kobe University Repository : Kernel タイトル Tit le Human Herpesvirus-6 U 14 Induces Cell-Cycle Arrest in G 2 / M Phase by Associat ing with a Cellular Protein

  2019cites this paper
• B-Myb is a crucial proviral host-factor and is involved in arenavirus mediated tumor suppression

  2017cites this paper
• Human Herpesvirus-6 U14 Induces Cell-Cycle Arrest in G2/M Phase by Associating with a Cellular Protein, EDD

  2015cites this paper
• The DR 6 protein from human herpesvirus-6 B induces p 53-independent cell cycle arrest in G 2 / M

  2014cites this paper
• The DR6 protein from human herpesvirus-6B induces p53-independent cell cycle arrest in G2/M.

  2014cites this paper
• Roseoloviruses manipulate host cell cycle.

  2014cites this paper