Advances in biological functions and mechanisms of histone variants in plants

Nucleosome is the basic subunit of chromatin, consisting of approximately 147bp DNA wrapped around a histone octamer, containing two copies of H2A, H2B, H3 and H4. A linker histone H1 can bind nucleosomes through its conserved GH1 domain, which may promote chromatin folding into higher-order structures. Therefore, the complexity of histones act importantly for specifying chromatin and gene activities. Histone variants, encoded by separate genes and characterized by only a few amino acids differences, can affect nucleosome packaging and stability, and then modify the chromatin properties. Serving as carriers of pivotal genetic and epigenetic information, histone variants have profound significance in regulating plant growth and development, response to both biotic and abiotic stresses. At present, the biological functions of histone variants in plant have become a research hotspot. Here, we summarize recent researches on the biological functions, molecular chaperons and regulatory mechanisms of histone variants in plant, and propose some novel research directions for further study of plant histone variants research field. Our study will provide some enlightens for studying and understanding the epigenetic regulation and chromatin specialization mediated by histone variant in plant.

• Publication year

  2023

• Venue

  Frontiers in Genetics

• Publication date

  2023-07-31

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.3389/fgene.2023.1229782PMID 37588047PMCID 10426802
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2022cited by this paper
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  2022influential reference
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  2022cited by this paper
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  2022cited by this paper
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  2022cited by this paper
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  2022cited by this paper
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  2022influential reference
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  2021cited by this paper
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  2021cited by this paper
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  2021cited by this paper
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  2021influential reference
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  2020influential reference
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  2020influential reference
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  2020cited by this paper
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  2020cited by this paper
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  2020cited by this paper
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  2020cited by this paper
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  2020cited by this paper
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  2019cited by this paper
• H2A Variants in Arabidopsis: Versatile Regulators of Genome Activity

  2019cited by this paper
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  2019cited by this paper
• Epigenetic regulation of miR396 expression by SWR1-C and the effect of miR396 on leaf growth and developmental phase transition in Arabidopsis

  2019cited by this paper
• The histone variant H2A.Z in gene regulation

  2019cited by this paper
• Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A.Z deposition

  2019cited by this paper
• The repressive role of Arabidopsis H2A.Z in transcriptional regulation depends on AtBMI1 activity

  2019cited by this paper
• High ambient temperature leads to reduced FT expression and delayed flowering in Brassica rapa via a mechanism associated with H2A.Z dynamics.

  2019cited by this paper
• The Evening Complex Establishes Repressive Chromatin Domains Via H2A.Z Deposition1

  2019cited by this paper
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  2018cited by this paper
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  2018cited by this paper
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  2018cited by this paper
• H2A.Z-containing nucleosomes are evicted to activate AtMYB44 transcription in response to salt stress.

  2018cited by this paper
• The Chromatin Remodelers PKL and PIE1 Act in an Epigenetic Pathway That Determines H3K27me3 Homeostasis in Arabidopsis

  2018cited by this paper
• Chromatin-remodeling factor OsINO80 is involved in regulation of gibberellin biosynthesis and is crucial for rice plant growth and development.

  2018cited by this paper
• Rice H2A.Z negatively regulates genes responsive to nutrient starvation but promotes expression of key housekeeping genes

  2018cited by this paper
• Methyl-CpG-binding domain 9 (MBD9) is required for H2A.Z incorporation into chromatin at a subset of H2A.Z-enriched regions in the Arabidopsis genome

  2018cited by this paper
• The plant-specific histone residue Phe41 is important for genome-wide H3.1 distribution

  2018cited by this paper
• H2A.Z promotes the transcription of MIR156A and MIR156C in Arabidopsis by facilitating the deposition of H3K4me3

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• Dual Role of the Histone Variant H2A.Z in Transcriptional Regulation of Stress-Response Genes[OPEN]

  2017cited by this paper
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  2017cited by this paper
• KLU suppresses megasporocyte cell fate through SWR1-mediated activation of WRKY28 expression in Arabidopsis

  2017cited by this paper
• Compartmentalization of DNA Damage Response between Heterochromatin and Euchromatin Is Mediated by Distinct H2A Histone Variants.

  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
• Histone H3 Dynamics Reveal Domains with Distinct Proliferation Potential in the Arabidopsis Root

  2016cited by this paper
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  2016cited by this paper
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  2015cited by this paper
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  2012cited by this paper
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  2011cited by this paper
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  2011cited by this paper
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  2010cited by this paper
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  2007cited by this paper
• Arabidopsis homologs of components of the SWR1 complex regulate flowering and plant development

  2007cited by this paper
• Repression of Flowering in Arabidopsis Requires Activation of FLOWERING LOCUS C Expression by the Histone Variant H2A.Z[W][OA]

  2007cited by this paper
• Constitutive Expression Exposes Functional Redundancy between the Arabidopsis Histone H2A Gene HTA1 and Other H2A Gene Family Members[OA]

  2006cited by this paper
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• H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy

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• ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex

  2004cited by this paper
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  2002cited by this paper
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  2001cited by this paper

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