Mycobacterium tuberculosis KatG(S315T) catalase-peroxidase retains all active site properties for proper catalytic function.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Biochemistry

• Publication date

  2005-01-11

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI048097FPMID 15628865
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enzyme-catalyzed Mechanism of Isoniazid Activation in Class I and Class III Peroxidases*

  2004cited by this paper
• Superoxide reactivity of KatG: insights into isoniazid resistance pathways in TB.

  2004cited by this paper
• Crystal Structure of Mycobacterium tuberculosis Catalase-Peroxidase*

  2004cited by this paper
• An Electrical Potential in the Access Channel of Catalases Enhances Catalysis*

  2003cited by this paper
• Analysis of Heme Structural Heterogeneity in Mycobacterium tuberculosis Catalase-Peroxidase (KatG)*

  2003cited by this paper
• Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution.

  2003cited by this paper
• Conformational differences in Mycobacterium tuberculosis catalase-peroxidase KatG and its S315T mutant revealed by resonance Raman spectroscopy.

  2003cited by this paper
• Reduced Affinity for Isoniazid in the S315T Mutant ofMycobacterium tuberculosis KatG Is a Key Factor in Antibiotic Resistance*

  2003cited by this paper
• Nitric-oxide Reductase

  2002cited by this paper
• The 2.0 Å crystal structure of catalase-peroxidase from Haloarcula marismortui

  2002cited by this paper
• UV resonance Raman detection of a ligand vibration on ferric nitrosyl heme proteins.

  2001cited by this paper
• Resonance Raman spectroscopic study of nitrophorin 1, a nitric oxide-binding heme protein from Rhodnius prolixus, and its nitrosyl and cyano adducts.

  2001cited by this paper
• Is the CO adduct of myoglobin bent, and does it matter?

  2001cited by this paper
• Carbon monoxide adducts of KatG and KatG(S315T) as probes of the heme site and isoniazid binding.

  2001cited by this paper
• Spectroscopic comparison of the heme active sites in WT KatG and its S315T mutant.

  2000cited by this paper
• The genetics and biochemistry of isoniazid resistance in mycobacterium tuberculosis.

  2000cited by this paper
• Catalase-peroxidase (Mycobacterium tuberculosis KatG) catalysis and isoniazid activation.

  2000cited by this paper
• Modulation of the activities of catalase-peroxidase HPI of Escherichia coli by site-directed mutagenesis.

  2000cited by this paper
• Mycobacterium tuberculosis KatG is a peroxynitritase.

  1999cited by this paper
• Use of site-directed mutagenesis to probe the structure, function and isoniazid activation of the catalase/peroxidase, KatG, from Mycobacterium tuberculosis.

  1999cited by this paper
• Inhibition of a Mycobacterium tuberculosis beta-ketoacyl ACP synthase by isoniazid.

  1998cited by this paper
• Evidence for differential binding of isoniazid by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG(S315T).

  1998cited by this paper
• Mechanisms of isoniazid resistance in Mycobacterium tuberculosis: enzymatic characterization of enoyl reductase mutants identified in isoniazid-resistant clinical isolates.

  1998cited by this paper
• Structural interactions between horseradish peroxidase C and the substrate benzhydroxamic acid determined by X-ray crystallography.

  1998cited by this paper
• Recombinant Mycobacterium tuberculosis KatG(S315T) is a competent catalase-peroxidase with reduced activity toward isoniazid.

  1997cited by this paper
• Crystal structure of horseradish peroxidase C at 2.15 Å resolution

  1997cited by this paper
• Overexpression, Purification, and Characterization of the Catalase-peroxidase KatG from Mycobacterium tuberculosis*

  1997cited by this paper
• The Role of Mn(II)-Peroxidase Activity of Mycobacterial Catalase-Peroxidase in Activation of the Antibiotic Isoniazid*

  1997cited by this paper
• Theoretical study of the distal-side steric and electrostatic effects on the vibrational characteristics of the FeCO unit of the carbonylheme proteins and their models.

  1996cited by this paper
• Purification and Characterization of the Mycobacterium smegmatis Catalase-Peroxidase Involved in Isoniazid Activation (*)

  1995cited by this paper
• Laser photolysis behavior of ferrous horseradish peroxidase with carbon monoxide and cyanide: effects of mutations in the distal heme pocket.

  1995cited by this paper
• Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

  1995cited by this paper
• inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.

  1994cited by this paper
• Characterization of recombinant horseradish peroxidase C and three site-directed mutants, F41V, F41W, and R38K, by resonance Raman spectroscopy.

  1994cited by this paper
• Characterization of interactions of nitric oxide with human hemoglobin A by infrared spectroscopy.

  1994cited by this paper
• Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis

  1993cited by this paper
• Distinct heme active-site structure in lactoperoxidase revealed by resonance Raman spectroscopy.

  1993cited by this paper
• Heme active-site structural characterization of chloroperoxidase by resonance Raman spectroscopy.

  1993cited by this paper
• On the use of iron octa-alkylporphyrins as models for protoporphyrin IX-containing heme systems in studies employing magnetic circular dichroism spectroscopy.

  1992cited by this paper
• Formation and photolability of low-spin ferrous cytochrome c peroxidase at alkaline pH.

  1992cited by this paper
• Ligand binding and structural perturbations in cytochrome c peroxidase. A crystallographic study.

  1990cited by this paper
• Resonance Raman enhancement of the Mn-N-O bending mode in nitrosyl manganese "strapped" and "open" heme complexes.

  1989cited by this paper
• Heme enzyme crystal structures.

  1988cited by this paper
• Is bound carbonyl linear or bent in heme proteins? Evidence from resonance Raman and infrared spectroscopic data.

  1988cited by this paper
• Probing structure-function relations in heme-containing oxygenases and peroxidases.

  1988cited by this paper
• Cytochrome c peroxidase mutant active site structures probed by resonance Raman and infrared signatures of the CO adducts.

  1988cited by this paper
• Two types of conformers with distinct Fe-C-O configuration in the ferrous CO complex of horseradish peroxidase. Resonance Raman and infarared spectroscopic studies with native and deuteroheme-substituted enzymes.

  1987cited by this paper
• Resonance Raman study on cytochrome c peroxidase and its intermediate. Presence of the Fe(IV) = O bond in compound ES and heme-linked ionization.

  1986cited by this paper
• Resonance Raman detection of Fe-CO stretching and Fe-C-O bending vibrations in sterically hindered carbonmonoxy "strapped hemes". A structural probe of Fe-C-O distortion.

  1983cited by this paper
• Resonance Raman studies of nitric oxide binding to ferric and ferrous hemoproteins: detection of Fe(III)--NO stretching, Fe(III)--N--O bending, and Fe(II)--N--O bending vibrations.

  1983cited by this paper
• Structural implication of the heme-linked ionization of horseradish peroxidase probed by the Fe-histidine stretching Raman line.

  1981cited by this paper
• Resonance Raman studies of hemoglobin complexes with nitric oxide, nitrosobenzene and nitrosomethane: observation of the metal-ligand vibrations.

  1977cited by this paper
• The chemical approach to the control of tuberculosis.

  1952cited by this paper

• Fitness Effect of the Isoniazid Resistance Mutation S315T of the Catalase-Peroxidase Enzyme KatG of Mycobacterium tuberculosis

  2025cites this paper
• Synergistic combination of antimicrobial peptide and isoniazid as inhalable dry powder formulation against multi-drug resistant tuberculosis.

  2024cites this paper
• An integrated computational investigation to unveil the structural impacts of mutation on the InhA structural gene of Mycobacterium tuberculosis.

  2020cites this paper
• Characterization of katG, inhA, rpoB and pncA in Mycobacterium tuberculosis isolates from MDR-TB risk patients in Thailand.

  2020cites this paper
• Modeling the structural origins of drug resistance to isoniazid via key mutations in Mycobacterium tuberculosis catalase-peroxidase, KatG.

  2018cites this paper
• Modeling the Structural Origins of Drug Resistance to Isoniazid via key Mutations in Mycobacterium tuberculosis Catalase-Peroxidase, KatG

  2017influential citation
• Antitubercular activity of Ru (II) isoniazid complexes.

  2015cites this paper
• The crystal structure of isoniazid‐bound KatG catalase‐peroxidase from Synechococcus elongatus PCC7942

  2015cites this paper
• Drug Discovery for TB: Frontiers and Perspectives

  2014cites this paper
• Synthesis, Characterization and Biological Activities of 2-Decylsulfonylacetamide Derivatives

  2012cites this paper
• Known drug response and resistance genes in INH and ETA [1] Gene Function Protein product Ref. INH ETA Mycolic acid pathway genes

  2012cites this paper
• Drug resistance mutations and heteroresistance detected using the GenoType MTBDRplus assay and their implication for treatment outcomes in patients from Mumbai, India

  2012cites this paper
• Understanding how the distal environment directs reactivity in chlorite dismutase: spectroscopy and reactivity of Arg183 mutants.

  2012cites this paper
• Direct detection of isoniazid-resistant Mycobacterium tuberculosis in respiratory specimens by multiplex allele-specific polymerase chain reaction.

  2011cites this paper
• Differential expression of genes in clinical strains of mycobacterium tuberculosis in response to isoniazid

  2011cites this paper
• Actinobacterial Peroxidases: an Unexplored Resource for Biocatalysis

  2011cites this paper
• Enzyme activity of catalase immobilized in Langmuir-Blodgett films of phospholipids.

  2010cites this paper
• Isoniazid‐resistance conferring mutations in Mycobacterium tuberculosis KatG: Catalase, peroxidase, and INH‐NADH adduct formation activities

  2010cites this paper
• Rifampin-Isoniazid Oligonucleotide Typing: an Alternative Format for Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis

  2010cites this paper
• A high prevalence of resistance in new tuberculosis cases of midwestern Brazil.

  2010cites this paper
• Horseradish peroxidase-catalyzed oxidation of chlorophyll a with hydrogen peroxide: characterization of the products and mechanism of the reaction.

  2010cites this paper
• A major subgroup of Beijing family Mycobacterium tuberculosis is associated with multidrug resistance and increased transmissibility

  2010cites this paper
• In house colorimetric reverse hybridisation assay for detection of the mutation most frequently associated with resistance to isoniazid in Mycobacterium tuberculosis.

  2009cites this paper
• Isoniazid-Resistance Conferring Mutations in Mycobacterium tuberculosis KatG : Catalase , Peroxidase , and INH-NADH Adduct Formation Activities by

  2009influential citation
• Tuberculosis: drug resistance, fitness, and strategies for global control

  2008cites this paper
• Convergent Evolutionary Analysis Identifies Significant Mutations in Drug Resistance Targets of Mycobacterium tuberculosis

  2008cites this paper
• UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL CENTRO DE BIOTECNOLOGIA PROGRAMA DE PÓS-GRADUAÇÃO EM BIOLOGIA CELULAR E MOLECULAR DETECÇÃO DA MUTAÇÃO MAIS FREQÜENTE NO CÓDON 315 DO GENE katG RELACIONADA COM A RESISTÊNCIA À ISONIAZIDA EM ISOLADOS DE Mycobacterium tuberculosis

  2008cites this paper
• Detecção da mutação mais freqüente no códon 315 do gene katG relacionada com a resistência à isoniazida em isolados de Mycobacterium tuberculosis

  2008cites this paper
• Modification of the active site of Mycobacterium tuberculosis KatG after disruption of the Met-Tyr-Trp cross-linked adduct.

  2007cites this paper
• Characterization of the binding of isoniazid and analogues to Mycobacterium tuberculosis catalase-peroxidase.

  2007cites this paper
• Overview of anti-tuberculosis (TB) drugs and their resistance mechanisms.

  2007cites this paper
• Antibiotic Resistance and Single-Nucleotide Polymorphism Cluster Grouping Type in a Multinational Sample of Resistant Mycobacterium tuberculosis Isolates

  2007cites this paper
• Probing the structure and bifunctionality of catalase-peroxidase (KatG).

  2006cites this paper
• Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.

  2006cites this paper
• Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis

  2006cites this paper
• Resonance Raman spectroscopy of Compound II and its decay in Mycobacterium tuberculosis catalase-peroxidase KatG and its isoniazid resistant mutant S315T.

  2005cites this paper
• Role of embB Codon 306 Mutations in Mycobacterium tuberculosis Revisited: a Novel Association with Broad Drug Resistance and IS6110 Clustering Rather than Ethambutol Resistance

  2005cites this paper