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Fusobacterium nucleatum and Prevotella in women with periodontitis and preterm birth

Karyne Martins Lima,Claudia Maria Coêlho Alves,F. Vidal,I. Gomes-Filho,Jéssica Costa e Costa,R. Coletta,V. Rodrigues,F. F. Lopes

Published 2023 in Medicina Oral

ABSTRACT

Background Studies try to explain the hypothesis that maternal periodontitis may be associated with preterm birth. Material and Methods This is a case-control study with 120, 40 cases (gestational age <37 weeks) and 80 controls (gestational age ≥37 weeks), that were submitted to the clinical periodontal examination and subgingival biofilm collection. Bacterial DNA of subgingival biofilm was performed and processed by qPCR. Results Periodontitis was statistically significant in the Case group (35%) when compared to the Control group (11.2%) and Gingival Bleeding Index (GBI), sites with PS ≥ 4mm and sites with CAL ≥ 5mm were statistically higher in the Case group (p < 0.05). The proportions of Pi (p = 0.026) and Fn (p = 0.041) of subgingival biofilm were higher in the Case group. A greater number of sites with PS ≥ 4mm (r = -0.202; p = 0.026) and CAL ≥ 5mm (r = -0.322; p < 0.001) were correlated to lower gestational age. Conclusions Periodontitis, preterm delivery, and/or low birth weight may have a possible relationship based on clinical parameters and the ratio of Pi and Fn at periodontal sites. Key words:Periodontal diseases, premature birth, fusobacterium nucleatum, prevotella intermedia.

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