Necessity and contingency in developmental genetic screens: EGF, Wnt and 2 semaphorin pathways in vulval induction of the nematode Oscheius tipulae 3

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• Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans.

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• The two steps of vulval induction in Oscheius tipulae CEW1 recruit common regulators including a MEK kinase.

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• Developmental system drift and flexibility in evolutionary trajectories

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• The nematode even-skipped homolog vab-7 regulates gonad and vulva position in Pristionchus pacificus.

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• mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans.

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• The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.

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• Robustness and Epistasis in the C. Elegans Vulval Signaling Network Revealed by Pathway Dosage Modulation

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• No citing papers are available for this paper.