p97 homologs from Caenorhabditis elegans, CDC‐48.1 and CDC‐48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Genes to Cells

• Publication date

  2008-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2443.2008.01214.xPMID 18782221
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Genome-Wide RNA 간섭 스크리닝을 위한 세포영상의 자동

  2010cited by this paper
• A toxic monomeric conformer of the polyglutamine protein

  2007cited by this paper
• Involvement of valosin‐containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates

  2007cited by this paper
• Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I.

  2007cited by this paper
• Characterization of the aggregation-prevention activity of p97/valosin-containing protein.

  2007influential reference
• Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

  2007cited by this paper
• Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

  2006influential reference
• Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state

  2006cited by this paper
• The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

  2006cited by this paper
• An arginine/lysine‐rich motif is crucial for VCP/p97‐mediated modulation of ataxin‐3 fibrillogenesis

  2006cited by this paper
• Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

  2004influential reference
• Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

  2004cited by this paper
• Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation.

  2004cited by this paper
• Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease

  2004cited by this paper
• Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.

  2004cited by this paper
• Analysis of the two p97/VCP/Cdc48p proteins of Caenorhabditis elegans and their suppression of polyglutamine-induced protein aggregation.

  2004cited by this paper
• Molecular perspectives on p97-VCP: progress in understanding its structure and diverse biological functions.

  2004influential reference
• The ClpB/Hsp104 molecular chaperone-a protein disaggregating machine.

  2004cited by this paper
• ATPase Activity of p97-Valosin-containing Protein (VCP)

  2003cited by this paper
• Function of the p97–Ufd1–Npl4 complex in retrotranslocation from the ER to the cytosol

  2003cited by this paper
• D1 Ring Is Stable and Nucleotide-independent, whereas D2 Ring Undergoes Major Conformational Changes during the ATPase Cycle of p97-VCP*

  2003cited by this paper
• Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains

  2003cited by this paper
• Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

  2003cited by this paper
• Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders.

  2003cited by this paper
• Vacuole-creating protein in neurodegenerative diseases in humans.

  2003cited by this paper
• AAA-ATPase p97/Cdc48p, a Cytosolic Chaperone Required for Endoplasmic Reticulum-Associated Protein Degradation

  2002cited by this paper
• Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle

  2002cited by this paper
• Role of the ubiquitin‐selective CDC48UFD1/NPL4 chaperone (segregase) in ERAD of OLE1 and other substrates

  2002influential reference
• Protein Dislocation from the Endoplasmic Reticulum – Pulling Out the Suspect

  2002influential reference
• Cdc48 can distinguish between native and non‐native proteins in the absence of cofactors

  2002cited by this paper
• Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration

  2002cited by this paper
• VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration

  2001influential reference
• Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation

  2001cited by this paper
• Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly

  2001cited by this paper
• Fourteen and counting: unraveling trinucleotide repeat diseases.

  2000cited by this paper
• Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity.

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB

  1999influential reference
• Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology.

  1999cited by this paper
• Organelle membrane fusion: a novel function for the syntaxin homolog Ufe1p in ER membrane fusion.

  1998cited by this paper
• Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

  1997cited by this paper
• Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.

  1997cited by this paper
• Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

  1997cited by this paper
• Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo.

  1997cited by this paper
• Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain.

  1997cited by this paper
• Heat-induced Chaperone Activity of HSP90 (*)

  1996cited by this paper
• Regulation of the Heat-shock Protein 70 Reaction Cycle by the Mammalian DnaJ Homolog, Hsp40*

  1996cited by this paper
• Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes.

  1995cited by this paper
• An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments.

  1995cited by this paper
• A direct colorimetric assay for Ca2+ -stimulated ATPase activity.

  1986cited by this paper

• Reversible protein assemblies in the proteostasis network in health and disease

  2023cites this paper
• Role of Unfolded Protein Response and Endoplasmic Reticulum-Associated Degradation by Repeated Exposure to Inhalation Anesthetics in Caenorhabditis elegans

  2021cites this paper
• The Cdc48-20S proteasome degrades a class of endogenous proteins in a ubiquitin-independent manner.

  2020cites this paper
• Golgi Structure and Function in Health, Stress, and Diseases

  2019cites this paper
• Function, dynamics and evolution of network motif modules in integrated gene regulatory networks of worm and plant

  2018cites this paper
• Two Cdc48 cofactors Ubp3 and Ubx2 regulate mitochondrial morphology and protein turnover

  2018cites this paper
• Cdc48 and ubiquilins confer selective anterograde protein sorting and entry into the multivesicular body in yeast

  2018cites this paper
• Protein Disaggregation in Multicellular Organisms.

  2018cites this paper
• Cln5 is secreted and functions as a glycoside hydrolase in Dictyostelium.

  2018cites this paper
• ER stress and cancer: The FOXO forkhead transcription factor link.

  2017cites this paper
• A Mighty “Protein Extractor” of the Cell: Structure and Function of the p97/CDC48 ATPase

  2017cites this paper
• Interaction between the AAA+ ATPase p97 and its cofactor ataxin3 in health and disease: Nucleotide-induced conformational changes regulate cofactor binding

  2017cites this paper
• Heterokaryon analysis of a Cdc48-like gene, CpCdc48, from the chestnut blight fungus Cryphonectria parasitica demonstrates it is essential for cell division and growth.

  2016cites this paper
• A non‐canonical role of the p97 complex in RIG‐I antiviral signaling

  2015cites this paper
• Inhibitors of the AAA+ Chaperone p97

  2015cites this paper
• Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins

  2015cites this paper
• Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.

  2015cites this paper
• Serial block-face scanning electron microscopy for three-dimensional analysis of morphological changes in mitochondria regulated by Cdc48p/p97 ATPase.

  2014cites this paper
• Create and preserve: proteostasis in development and aging is governed by Cdc48/p97/VCP.

  2014cites this paper
• Recent advances in p97/VCP/Cdc48 cellular functions.

  2012cites this paper
• Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

  2012cites this paper
• The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins

  2012cites this paper
• Cdc48p/p97-mediated regulation of mitochondrial morphology is Vms1p-independent.

  2012cites this paper
• The Aggregation of Huntingtin and α-Synuclein

  2012cites this paper
• Protein homeostasis and aging: role of ubiquitin protein ligases.

  2012cites this paper
• Validation of HDAC6 and SIRT2 tubulin deacetylases as therapeutic targets for Huntington's disease

  2012cites this paper
• Positive Cooperativity of the p97 AAA ATPase Is Critical for Essential Functions*

  2011cites this paper
• The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System

  2011cites this paper
• Applying Hsp104 to protein-misfolding disorders.

  2010cites this paper
• ATP-bound form of the D1 AAA domain inhibits an essential function of Cdc48p/p97.

  2010cites this paper
• Caenorhabditis elegans UBX cofactors for CDC‐48/p97 control spermatogenesis

  2010cites this paper
• Nervous yeast: modeling neurotoxic cell death.

  2010cites this paper
• Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans.

  2010cites this paper
• Mitochondrial Enzyme Rhodanese Is Essential for 5 S Ribosomal RNA Import into Human Mitochondria*

  2010cites this paper
• Endoplasmic reticulum associated degradation of glycoproteins in Caenorhabditis elegans.

  2009cites this paper
• Index

  2008cites this paper