Red/NIR Emissive AIE-active Photosensitizers with Strong Donor-Acceptor Strength for Image-Guided Photodynamic Therapy of Cancer.

Light-mediated therapies such as photodynamic therapy (PDT) is considered as emerging cancer treatment strategies. However, there are still lots of defect with common photosensitizers (PSs), such as short emission wavelength, week photostability, poor cell permeability and low PDT efficiency. Therefore, it is very important to develop high-performance PSs. Recently, luminogens with aggregation-induced emission (AIE) characteristics and Red/near-infrared (NIR) emissive have been reported as promising PSs for image-guided cancer therapy, due to prevent autofluorescence in physiological environments, their enhanced fluorescence in the aggregated state and generation of reactive oxygen species (ROS). Herein, we developed PSs named TBTCPM and MTBTCPM with donor-acceptor (D-A) structures, strong Red/near intra-red (NIR), excellent targeting specificities to good cell permeability and high photostability. Interestingly, both of them can efficiently generate reactive oxygen species under white light irradiation and possess excellent killing effect on cancer cells. This study, thus, not only demonstrates applications in cell image-guided PDT cancer therapy performances. but also provide strategy for construction of AIEgens with long emission wavelengths.

• Publication year

  2023

• Venue

  Luminescence (Chichester, England Print)

• Publication date

  2023-09-22

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1002/bio.4599PMID 37740529
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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