Psilocybin analog 4-OH-DiPT enhances fear extinction and GABAergic inhibition of principal neurons in the basolateral amygdala

No abstract is available for this paper.

• Publication year

  2023

• Venue

  Neuropsychopharmacology

• Publication date

  2023-09-26

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1038/s41386-023-01744-8PMID 37752222PMCID PMC10948882
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Posttraumatic stress disorder in the National Comorbidity Survey.

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