HIV‐1 Tat protein down‐regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3‐kinase/AKT/cyclic nucleoside phosphodiesterase pathway

No abstract is available for this paper.

• Publication year

  2001

• Venue

  The FASEB Journal

• Publication date

  2001-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1096/fj.00-0354comPMID 11156964
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Loss of neurons in the frontal cortex in AIDS brains

  2004cited by this paper
• GM1 ganglioside induces phosphorylation and activation of Trk and Erk in brain

  2002cited by this paper
• Vaccination with tat toxoid attenuates disease in simian/HIV-challenged macaques.

  2000cited by this paper
• HIV-1 Tat-mediated Inhibition of the Tyrosine Hydroxylase Gene Expression in Dopaminergic Neuronal Cells*

  2000cited by this paper
• Tat as one key to HIV-induced immune pathogenesis and Pat toxoid as an important component of a vaccine

  1999cited by this paper
• HIV‐1 Tat‐Mediated Activation of Glycogen Synthase Kinase‐3β Contributes to Tat‐Mediated Neurotoxicity

  1999cited by this paper
• Transient Exposure to HIV-1 Tat Protein Results in Cytokine Production in Macrophages and Astrocytes

  1999cited by this paper
• Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt

  1999cited by this paper
• Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine

  1999cited by this paper
• Tat as one key to HIV-induced immune pathogenesis and Tat (correction of Pat) toxoid as an important component of a vaccine.

  1999cited by this paper
• Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.

  1999cited by this paper
• In vivo protein transduction: delivery of a biologically active protein into the mouse.

  1999cited by this paper
• HIV-1 Tat Induces Neuronal Death via Tumor Necrosis Factor-α and Activation of Non-N-methyl-d-aspartate Receptors by a NFκB-Independent Mechanism*

  1998cited by this paper
• HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism.

  1998cited by this paper
• HIV‐1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3‐kinase in PC12 cells

  1998cited by this paper
• Inducible cAMP early repressor ICER down-regulation of CREB gene expression in Sertoli cells.

  1998cited by this paper
• Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase.

  1998cited by this paper
• CREB Is a Regulatory Target for the Protein Kinase Akt/PKB*

  1998cited by this paper
• Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes.

  1998cited by this paper
• Safety and immunogenicity of HIV-1 Tat toxoid in immunocompromised HIV-1-infected patients.

  1998cited by this paper
• Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase.

  1998cited by this paper
• Regression of HIV encephalopathy and basal ganglia signal intensity abnormality at MR imaging in patients with AIDS after the initiation of protease inhibitor therapy.

  1998cited by this paper
• HIV-1 Tat protein mimicry of chemokines.

  1998cited by this paper
• HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress.

  1998cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

  1997cited by this paper
• Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum.

  1997cited by this paper
• Neuronal excitatory properties of human immunodeficiency virus type 1 Tat protein.

  1997cited by this paper
• Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic

  1996cited by this paper
• Extracellular Human Immunodeficiency Virus Type-1 Tat Protein Activates Phosphatidylinositol 3-Kinase in PC12 Neuronal Cells*

  1996cited by this paper
• Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

  1996cited by this paper
• The angiogenesis induced by HIV–1 Tat protein is mediated by the Flk–1/KDR receptor on vascular endothelial cells

  1996cited by this paper
• Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

  1995cited by this paper
• Evidence of apoptotic cell death in HIV encephalitis.

  1995cited by this paper
• Transcription factors responsive to cAMP.

  1995cited by this paper
• Neurotoxicity of the human immunodeficiency virus type 1 Tat transactivator to PC12 cells requires the Tat amino acid 49‐58 basic domain

  1995cited by this paper
• An autocrine loop of HIV type-1 Tat protein responsible for the improved survival/proliferation capacity of permanently Tat-transfected cells and required for optimal HIV-1 LTR transactivating activity.

  1995cited by this paper
• Human immunodeficiency virus type 1 tat activates non—N‐methyl‐D‐aspartate excitatory amino acid receptors and causes neurotoxicity

  1995cited by this paper
• HIV‐1 encephalopathy in children

  1995cited by this paper
• Neuronal apoptosis in HIV infection in adults

  1995cited by this paper
• Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms.

  1995influential reference
• CREB: a mediator of long-term memory from mollusks to mammals.

  1994cited by this paper
• The basic domain of the lentiviral Tat protein is responsible for damages in mouse brain: involvement of cytokines.

  1994cited by this paper
• Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

  1994cited by this paper
• Control of RNA initiation and elongation at the HIV-1 promoter.

  1994cited by this paper
• Human immunodeficiency virus type 1 Tat activity in human neuronal cells: uptake and trans-activation.

  1994cited by this paper
• Tat-mediated delivery of heterologous proteins into cells.

  1994cited by this paper
• CREB: A mediator of long-term memory from mollusks to mammals

  1994cited by this paper
• The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription.

  1993cited by this paper
• The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.

  1993cited by this paper
• Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alterations of the blood‐brain barrier

  1993cited by this paper
• Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

  1992cited by this paper
• Assignment of the gene for cyclic AMP-response element binding protein 2 (CREB2) to human chromosome 2q24.1-q32.

  1991cited by this paper
• HIV‐1, macrophages, glial cells, and cytokines in AIDS nervous system disease

  1991cited by this paper
• CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases.

  1991cited by this paper
• Neuronal loss in the frontal cortex in HIV infection.

  1991cited by this paper
• Morphology and distribution of HIV-1 gp41-positive microglia in subacute AIDS encephalitis. Pattern of involvement resembling a multisystem degeneration.

  1990cited by this paper
• Multiple adenosine 3',5'-cyclic [corrected] monophosphate response element DNA-binding proteins generated by gene diversification and alternative exon splicing.

  1990cited by this paper
• Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

  1990cited by this paper
• Multiple Adenosine 3',5'- Monophosphate Response Element DNA-Binding Proteins Generated by Gene Diversification and Alternative Exon Splicing

  1990cited by this paper
• Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.

  1989cited by this paper
• Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

  1988cited by this paper

• The role of exosomes and microRNA in Astrocyte-mediated HIV-1 Tat neurotoxicity

  2016cites this paper
• HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

  2016cites this paper
• BRCA1 functions as a novel transcriptional cofactor in HIV-1 infection

  2015cites this paper
• HIV-1 TAT and IMMUNE DYSREGULATION in AIDS PATHOGENESIS: a THERAPEUTIC TARGET.

  2015cites this paper
• Régulations de la sécrétion et de l’activité biologique de la protéine Tat du VIH-1 : rôles de la palmitoylation et de Gag

  2014influential citation
• Involvement of the PI3K and ERK signaling pathways in largemouth bass virus-induced apoptosis and viral replication.

  2014cites this paper
• HIV Associated Neurocognitive Disorders

  2013cites this paper
• synthase acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide phosphatidylinositol-3 kinase-dependent reduction of ceramide through Interleukin-2-induced survival of natural killer (NK) cells involving

  2013cites this paper
• Molecule of the month HIV-1 Tat and miRNA

  2012cites this paper
• Infectious Agents and Neurodegeneration

  2012cites this paper
• HIV-1 Tat and HIV-associated Dementia

  2012cites this paper
• HIV-1 Tat binds to SH3 domains: cellular and viral outcome of Tat/Grb2 interaction.

  2011cites this paper
• HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: implication for HIV-associated neurocognitive disorder (HAND).

  2011cites this paper
• Genome-Wide Association Study Identifies Single Nucleotide Polymorphism in DYRK1A Associated with Replication of HIV-1 in Monocyte-Derived Macrophages

  2011influential citation
• HIV-1 Tat binds to SH 3 domains : Cellular and viral outcome of Tat / Grb 2 interaction

  2011cites this paper
• HIV-1 Tat Protein Promotes Neuronal Dysfunction through Disruption of MicroRNAs*

  2011cites this paper
• Host genetic effects on HIV-1 replication in macrophages

  2011cites this paper
• Functions of Tat: the versatile protein of human immunodeficiency virus type 1.

  2010cites this paper
• Antiretroviral Therapy Down-Regulates Innate Antiviral Response Genes in Patients With AIDS in Sub-Saharan Africa

  2010cites this paper
• EARLY DETECTION OF SUBTYPE-SPECIFIC HIV-1 INFECTION USING TRANSCRIPTOMES FROM HOST CELL RESPONSES

  2010cites this paper
• Vpu Mediated Enhancement of Human Immunodeficiency Virus Pathogenesis: The Role of Conserved and Unique Domains in Protein Function

  2010cites this paper
• Mise en évidence de l'interaction de la protéine tat du VIH-1 avec les pentraxines humaines : Impact sur la transcription du VIH et la différenciation des cellules dendritiques

  2010cites this paper
• HIV-Tat Protein mediation of NeuroAIDS central nervous system pathology and behavioral deficits

  2010influential citation
• Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Alters Parasympathetic Neuron Gene Expression in a Time-dependent Fashion

  2008cites this paper
• Pituitary Adenylate Cyclase Activating Polypeptide Signaling Alters Gene Expression In Chick Ciliary Ganglion Neurons

  2008cites this paper
• Sulfated polymannuroguluronate, a novel anti‐acquired immune deficiency syndrome drug candidate, decreased vulnerability of PC12 cells to human immunodeficiency virus tat protein through attenuating calcium overload

  2008cites this paper
• Neuropharmacology of HIV/AIDS.

  2007cites this paper
• Influenza A viruses and PI3K signalling

  2007cites this paper
• Regulation of neural cell survival by HIV-1 infection.

  2006cites this paper
• Platelet-Derived Growth Factor BB Induces Nuclear Export and Proteasomal Degradation of CREB via Phosphatidylinositol 3-Kinase/Akt Signaling in Pulmonary Artery Smooth Muscle Cells

  2006cites this paper
• Human immunodeficiency virus‐encoded Tat activates glycogen synthase kinase‐3β to antagonize nuclear factor‐κB survival pathway in neurons

  2006cites this paper
• Human immunodeficiency virus-encoded Tat activates glycogen synthase kinase-3beta to antagonize nuclear factor-kappaB survival pathway in neurons.

  2006cites this paper
• Interference with cAMP Response Element Binding Protein (CREB) stimulates apoptosis through aberrant cell cycle progression and checkpoint activation

  2006cites this paper
• Jane Muscle Cells Signaling in Pulmonary Artery Smooth Phosphatidylinositol 3-Kinase / Akt Degradation of CREB via Nuclear Export and Proteasomal Platelet-Derived Growth Factor BB Induces

  2006cites this paper
• Interference with 3',5'-cyclic adenosine monophosphate response element binding protein stimulates apoptosis through aberrant cell cycle progression and checkpoint activation.

  2006cites this paper
• Early impairment in dopaminergic neurotransmission in brains of SIV‐infected rhesus monkeys due to microglia activation

  2005cites this paper
• Cell death in HIV dementia

  2005cites this paper
• Cross talk between growth factors and viral and cellular factors alters neuronal signaling pathways: implication for HIV-associated dementia.

  2005cites this paper
• Peripheral nerve-derived HIV-1 is predominantly CCR5-dependent and causes neuronal degeneration and neuroinflammation.

  2005cites this paper
• HIV-1 Tat Interactions with p300 and PCAF Transcriptional Coactivators Inhibit Histone Acetylation and Neurotrophin Signaling through CREB*

  2005cites this paper
• Molecular targets of opiate drug abuse in neuro AIDS

  2005cites this paper
• HIV-1 Infection and Cell Death in the Nervous System

  2005cites this paper
• Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.

  2004cites this paper
• Dopamine deficits and regulation of the cAMP second messenger system in brains of simian immunodeficiency virus-infected rhesus monkeys

  2004cites this paper
• Multiple Actions of the Human Immunodeficiency Virus Type-1 Tat Protein on Microglial Cell Functions

  2004cites this paper
• Tumour necrosis factor‐related apoptosis‐inducing ligand sequentially activates pro‐survival and pro‐apoptotic pathways in SK‐N‐MC neuronal cells

  2003cites this paper
• Reactive oxygen species and molecular regulation of renal oxygenation.

  2003cites this paper
• EGFR family signaling and its association with breast cancer development and resistance to chemotherapy (Review).

  2003cites this paper
• Involvement of Cyclic GMP and Protein Kinase G in the Regulation of Apoptosis and Survival in Neural Cells

  2002cites this paper
• External Qi of Yan Xin Life Science Technology Can Revive or Suppress Enzyme Activity of Phosphatidylinositol 3-Kinase

  2002cites this paper
• HIV-1-Tat Protein Activates Phosphatidylinositol 3-Kinase/ AKT-dependent Survival Pathways in Kaposi's Sarcoma Cells*

  2002cites this paper
• Inhibition of cAMP-response Element-binding Protein Activity Decreases Protein Kinase B/Akt Expression in 3T3-L1 Adipocytes and Induces Apoptosis*

  2002cites this paper
• A time to kill: viral manipulation of the cell death program.

  2002cites this paper
• Involvement of the PI 3 K and ERK signaling pathways in largemouth bass virus-induced apoptosis and viral replication

  year unknowncites this paper