The aetiology of sperm protamine abnormalities and their potential impact on the sperm epigenome.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  International Journal of Andrology

• Publication date

  2008-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1365-2605.2008.00872.xPMID 18298569
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Anomalous distribution of nuclear basic proteins in round‐headed human spermatozoa: Anormale Verteilung basischer Kern‐Proteine in menschlichen rundköpfigen Spermatozoen

  2009cited by this paper
• Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients.

  2007cited by this paper
• Testis/sperm-specific histone 2B in the sperm of donors and subfertile patients: variability and relation to chromatin packaging.

  2007cited by this paper
• Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

  2007influential reference
• Mutations in the protamine 1 gene associated with male infertility.

  2007cited by this paper
• Identification of Genetic Variation in the 5′ and 3′ Non-coding Regions of the Protamine Genes in Patients with Protamine Deregulation

  2007cited by this paper
• The Genetics of Male Infertility in the Era of Genomics

  2007cited by this paper
• The histone to protamine ratio in human spermatozoa: comparative study of whole and processed semen.

  2007cited by this paper
• Altered protamine expression and diminished spermatogenesis: what is the link?

  2007cited by this paper
• Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs.

  2007cited by this paper
• A successful pregnancy outcome using testicular sperm from an infertile male pretreated with HCG.

  2007cited by this paper
• Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility.

  2006cited by this paper
• Sperm nuclear histone to protamine ratio in fertile and infertile men: evidence of heterogeneous subpopulations of spermatozoa in the ejaculate.

  2006cited by this paper
• Sperm Nuclear Histone to Protamine Ratio in Fertile and Infertile Men: Evidence of Heterogeneous Subpopulations of Spermatozoa in the Ejaculate

  2006cited by this paper
• Global sperm deoxyribonucleic acid methylation is unaffected in protamine-deficient infertile males.

  2006cited by this paper
• Protamines and male infertility.

  2006influential reference
• A novel mechanism of protamine expression deregulation highlighted by abnormal protamine transcript retention in infertile human males with sperm protamine deficiency.

  2006cited by this paper
• Sperm protamine 1/protamine 2 ratios are related to in vitro fertilization pregnancy rates and predictive of fertilization ability.

  2006cited by this paper
• Protamine levels vary between individual sperm cells of infertile human males and correlate with viability and DNA integrity.

  2006cited by this paper
• The controversy, potential and roles of spermatozoal RNA.

  2005cited by this paper
• Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males.

  2005cited by this paper
• An SNP in protamine 1: a possible genetic cause of male infertility?

  2005cited by this paper
• Eukaryotic cytosine methyltransferases.

  2005cited by this paper
• Identification and evaluation of a novel sperm protamine abnormality in a population of infertile males.

  2005influential reference
• The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells.

  2005cited by this paper
• Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility.

  2005cited by this paper
• Toward using stable spermatozoal RNAs for prognostic assessment of male factor fertility.

  2005cited by this paper
• DNA integrity is compromised in protamine-deficient human sperm.

  2005cited by this paper
• Genomic imprinting in disruptive spermatogenesis.

  2004cited by this paper
• Patterns, mechanisms, and functions of translation regulation in mammalian spermatogenic cells

  2004cited by this paper
• Male germline-specific histones in mouse and man

  2004cited by this paper
• Relationship between protamine deficiency with fertilization rate and incidence of sperm premature chromosomal condensation post‐ICSI

  2004influential reference
• Transient DNA Strand Breaks During Mouse and Human Spermiogenesis: New Insights in Stage Specificity and Link to Chromatin Remodeling1

  2004cited by this paper
• Effect of human sperm chromatin anomalies on fertilization outcome post‐ICSI

  2003cited by this paper
• The Structural Organization of Sperm Chromatin*

  2003cited by this paper
• CTCF maintains differential methylation at the Igf2/H19 locus

  2003cited by this paper
• Human protamines and the developing spermatid: their structure, function, expression and relationship with male infertility.

  2003cited by this paper
• Patterns, mechanisms, and functions of translation regulation in mammalian spermatogenic cells.

  2003cited by this paper
• Expression of mammalian spermatozoal nucleoproteins

  2003cited by this paper
• Single nucleotide polymorphisms in the protamine-1 and -2 genes of fertile and infertile human male populations.

  2003cited by this paper
• BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma

  2002cited by this paper
• The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer.

  2002cited by this paper
• Spermatozoal RNA profiles of normal fertile men.

  2002cited by this paper
• DNA methylation patterns and epigenetic memory.

  2002cited by this paper
• Protamine 1: Protamine 2 stoichiometry in the sperm of eutherian mammals *

  2002influential reference
• Protamine-1 and -2 mRNA in round spermatids is associated with RNA-binding proteins

  2002cited by this paper
• RNA-Binding Properties and Translation Repression In Vitro by Germ Cell-Specific MSY2 Protein1

  2002cited by this paper
• Altered protamine 2 expression is uncommon in donors of known fertility, but common among men with poor fertilizing capacity, and may reflect other abnormalities of spermiogenesis.

  2001cited by this paper
• Expression of the TAR RNA binding protein in human testis.

  2001cited by this paper
• Large-scale human promoter mapping using CpG islands

  2000cited by this paper
• A sequence-specific RNA binding complex expressed in murine germ cells contains MSY2 and MSY4.

  2000cited by this paper
• Genome organization in the human sperm nucleus studied by FISH and confocal microscopy

  2000cited by this paper
• Contrin, the human homologue of a germ-cell Y-box-binding protein: cloning, expression, and chromosomal localization.

  1999cited by this paper
• A complex population of RNAs exists in human ejaculate spermatozoa: implications for understanding molecular aspects of spermiogenesis.

  1999cited by this paper
• A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells

  1999cited by this paper
• A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon DNA.

  1999cited by this paper
• Round spermatids show normal testis-specific H1t but reduced cAMP-responsive element modulator and transition protein 1 expression in men with round-spermatid maturation arrest.

  1999cited by this paper
• Transcriptional and translational regulation of gene expression in haploid spermatids

  1999cited by this paper
• Protamine Mediated Condensation of DNA in Mammalian Sperm

  1999influential reference
• Characterization of aneuploidy rates, protamine levels, ultrastructure, and functional ability of round-headed sperm from two siblings and implications for intracytoplasmic sperm injection.

  1999cited by this paper
• The male gamete : from basic science to clinical applications

  1999influential reference
• Mammalian male and female germ cells express a germ cell-specific Y-Box protein, MSY2.

  1998cited by this paper
• Histone- and Protamine-DNA Association: Conservation of Different Patterns within the β-Globin Domain in Human Sperm

  1998cited by this paper
• Detection of P2 precursors in the sperm cells of infertile patients who have reduced protamine P2 levels.

  1998cited by this paper
• Expression of mRNA and protein of nucleoproteins during human spermiogenesis.

  1998cited by this paper
• RNA in spermatozoa: implications for the alternative haploid genome.

  1997cited by this paper
• Haploid transcripts persist in mature human spermatozoa.

  1997cited by this paper
• RNA-binding proteins and human male infertility.

  1997cited by this paper
• A testis cytoplasmic RNA-binding protein that has the properties of a translational repressor

  1996cited by this paper
• A role for Y-box proteins in cell proliferation.

  1995cited by this paper
• The nuclear status of human sperm cells.

  1995cited by this paper
• Gametic Imprinting in Mammals

  1995cited by this paper
• Premature translation of protamine 1 mRNA causes precocious nuclear condensation and arrests spermatid differentiation in mice.

  1995cited by this paper
• GA repeat polymorphism at the PRM2 male fertility locus.

  1994cited by this paper
• A (GA)n repeat polymorphism in the human protamine 2 (PRM 2) gene.

  1994cited by this paper
• Structural and functional properties of the evolutionarily ancient Y‐box family of nucleic acid binding proteins

  1994cited by this paper
• Differential RNA fingerprinting as a tool in the analysis of spermatozoal gene expression.

  1994cited by this paper
• Role for DNA methylation in genomic imprinting

  1993cited by this paper
• Human male infertility may be due to a decrease of the protamine P2 content in sperm chromatin

  1993cited by this paper
• Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA.

  1993cited by this paper
• Selective recruitment of masked maternal mRNA from messenger ribonucleoprotein particles containing FRGY2 (mRNP4).

  1993cited by this paper
• A mouse Y box protein, MSY1, is associated with paternal mRNA in spermatocytes.

  1993cited by this paper
• Highly acetylated H4 is associated with histone displacement in rat spermatids

  1992cited by this paper
• The Y-box factors: a family of nucleic acid binding proteins conserved from Escherichia coli to man.

  1992cited by this paper
• Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.

  1992cited by this paper
• Binding of Xenopus oocyte masking proteins to mRNA sequences.

  1992cited by this paper
• Vertebrate protamine genes and the histone-to-protamine replacement reaction.

  1991cited by this paper
• Regulation of 'haploid expressed genes' in male germ cells.

  1990cited by this paper
• Isolation of four core histones from human sperm chromatin representing a minor subset of somatic histones.

  1990cited by this paper
• Fertility and Sterility

  1988influential reference
• Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males

  1988cited by this paper
• Translation of mouse testis poly(A)+ mRNAs for testis-specific protein, protamine 1, and the precursor for protamine 2.

  1987cited by this paper
• Sequence-specific packaging of DNA in human sperm chromatin.

  1987cited by this paper
• Anomalous protein complement of sperm nuclei in some infertile men.

  1987cited by this paper
• Translational regulation and deadenylation of a protamine mRNA during spermiogenesis in the mouse.

  1984cited by this paper
• Reversible inhibition of translation by Xenopus oocyte-specific proteins

  1984cited by this paper
• Hyperacetylation of histone H4 in rat testis spermatids.

  1984cited by this paper
• Histones instead of protamines in terminal germ cells of infertile, oligospermic men.

  1976cited by this paper
• Trout testis cells. 3. Acetylation of histones in different cell types from developing trout testis.

  1972cited by this paper

• Genetic and epigenetic landscape of male infertility.

  2025cites this paper
• Protamine 2 Deficiency Results In Septin 12 Abnormalities

  2024cites this paper
• Protamine 2 deficiency results in Septin 12 abnormalities

  2024cites this paper
• Associations between Sperm Epigenetic Age and Semen Parameters: An Evaluation of Clinical and Non-Clinical Cohorts

  2024cites this paper
• Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring

  2023cites this paper
• Susceptibility to azoospermia by haplotype analysis of protamine 1 and protamine 2 variants

  2023cites this paper
• Environmental and Genetic Traffic in the Journey from Sperm to Offspring

  2023cites this paper
• Effect of pesticide exposure on human sperm characteristics, genome integrity, and methylation profile analysis

  2023cites this paper
• Insights into the sperm chromatin and implications for male infertility from a protein perspective.

  2022cites this paper
• Lack of trusted diagnostic tools for undetermined male infertility

  2021cites this paper
• The Transgenerational Transmission of the Paternal Type 2 Diabetes-Induced Subfertility Phenotype

  2021cites this paper
• Sperm chromatin protamination influences embryo development in unsexed and sexed bull semen.

  2021cites this paper
• Exploring the Stress Impact in the Paternal Germ Cells Epigenome: Can Catecholamines Induce Epigenetic Reprogramming?

  2021cites this paper
• Genetics of Male Infertility: A Case-Based Guide for Clinicians

  2020cites this paper
• Effect of protamine and Its abnormalities on male fertility potential

  2020cites this paper
• Semiquantitative promoter methylation of MLH1 and MSH2 genes and their impact on sperm DNA fragmentation and chromatin condensation in infertile men

  2020cites this paper
• New Developments for the Enhancement of Male Reproductive Health Using Antioxidant Therapy: A Critical Review of the Literature

  2020cites this paper
• Developmental origins of transgenerational sperm histone retention following ancestral exposures.

  2020cites this paper
• Relation between sperm protamine transcripts with global sperm DNA methylation and sperm DNA methyltransferases mRNA in men with severe sperm abnormalities

  2019cites this paper
• The polymorphism of XRCC1 Arg399Gln (rs25487) and male infertility risk: a meta-analysis of 1,407 cases and 974 control studies.

  2019cites this paper
• Association of protamine1 gene c.-190C>A polymorphism with male infertility risk: a meta-analysis

  2019cites this paper
• Endocrine Disruptors: Very Low Doses with Genuinely High Impacts on Male Reproduction

  2019cites this paper
• The Sperm Epigenome: Implications for Assisted Reproductive Technologies.

  2019cites this paper
• The impact of cigarette smoking on protamines 1 and 2 transcripts in human spermatozoa

  2019cites this paper
• Nuclear sperm quality in total polymorphic teratozoospermia and its impact on intracytoplasmic sperm injection outcome

  2019cites this paper
• Quantification of histones and protamines mRNA transcripts in sperms of infertile couples and their impact on sperm's quality and chromatin integrity.

  2019cites this paper
• Epigenetic landscape of infertility

  2019cites this paper
• DNA Methylation and Regulatory Elements during Chicken Germline Stem Cell Differentiation

  2018cites this paper
• Indicative and Prognostic Ramifications in the Assessment of DNA Sperm Damage: The Essential Standards, the Blueprint Procedures, Clinical Procedures, Clinical Importance and Implications of These Tests: A Systematic Review

  2018cites this paper
• Transmission electron microscopy analysis of the origin and incidence of sperm intranuclear cytoplasmic retention in fertile and teratozoospermia men

  2018cites this paper
• Sperm DNA damage is the single largest cause of defective sperm function and may be the underlying cause of idiopathic male infertility. According to the WHO published data, male infertility contributes to about 45–50% cases of infertility

  2018cites this paper
• Defective Spermatogenesis and Sperm DNA Damage

  2018cites this paper
• Improving the outcome of in vitro embryo production through microfluidic technology

  2018cites this paper
• The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo.

  2018cites this paper
• Polymorphisms in protamine 1 and 2 genes in asthenozoospermic men: A case-control study

  2018cites this paper
• Transgenerational inheritance of susceptibility to diabetes-induced male subfertility

  2017cites this paper
• Elimination of methylation marks at lysines 4 and 9 of histone 3 (H3K4 and H3K9) of spermatozoa alters offspring phenotype.

  2017cites this paper
• Fertility and Sperm Quality in the Aging Male.

  2017cites this paper
• Possible Distorting Effects of Gef26 in Drosophila Melanogaster

  2017cites this paper
• Human Fertility an international , multidisciplinary journal dedicated to furthering research and promoting good practice

  2017cites this paper
• The role of epigenetics in idiopathic male infertility

  2016cites this paper
• The Environmental Factors and Epigenetics of Gametogenesis in Puberty

  2016cites this paper
• The “omics” of human male infertility: integrating big data in a systems biology approach

  2015cites this paper
• Post‐Translational Modifications of Histones in Human Sperm

  2015influential citation
• Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

  2015cites this paper
• Epigenetic Alterations in Density Selected Human Spermatozoa for Assisted Reproduction

  2015cites this paper
• Impact of sperm genome decay on Day‐3 embryo chromosomal abnormalities from advanced‐maternal‐age patients

  2015cites this paper
• Human sperm chromatin epigenetic potential: genomics, proteomics, and male infertility

  2015cites this paper
• Genetic Basis of Unexplained Male Infertility

  2015cites this paper
• The role of epigenetics in spermatogenesis.

  2014cites this paper
• Cigarette smoking is associated with abnormal histone-to-protamine transition in human sperm.

  2014cites this paper
• Male infertility: biomolecular aspects

  2014cites this paper
• Genomic and proteomic dissection and characterization of the human sperm chromatin.

  2014cites this paper
• Morphological alterations in protamine-deficient spermatozoa.

  2014cites this paper
• Sperm nuclear proteome and its epigenetic potential

  2014cites this paper
• The effect of tetrabromobisphenol A on protamine content and DNA integrity in mouse spermatozoa

  2014influential citation
• Assessment of Chromatin Maturity in Human Spermatozoa: Useful Aniline Blue Assay for Routine Diagnosis of Male Infertility

  2013cites this paper
• Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation

  2013cites this paper
• A comparison of DNA compaction by arginine and lysine peptides: a physical basis for arginine rich protamines.

  2013cites this paper
• Sperm DNA Hasarı Mekanizmaları ve Değerlendirme Yöntemleri

  2013cites this paper
• Supraphysiological Free Radical Levels and their Pathogenesis in Male Infertility

  2012cites this paper
• Altered histone retention and epigenetic modifications in the sperm of infertile men.

  2012cites this paper
• Epigenetics of the male gamete.

  2012cites this paper
• Genome-wide sperm deoxyribonucleic acid methylation is altered in some men with abnormal chromatin packaging or poor in vitro fertilization embryogenesis.

  2012cites this paper
• Chromatin remodelling initiation during human spermiogenesis

  2012cites this paper
• Possible Distorting Effects of Gef26 in Drosophila Melanogaster

  2012cites this paper
• QUALIDADE ESPERMÁTICA E DANOS DE DNA EM ESPERMATOZOIDES CRIOPRESERVADOS DE TOUROS NELORE JOVENS, ADULTOS E SENIS.

  2012cites this paper
• Caracterización múltiple de la fragmentación del adn espermático en pacientes infértiles

  2012cites this paper
• The sperm epigenome and potential implications for the developing embryo.

  2012cites this paper
• Protamine-1 and -2 polymorphisms and gene expression in male infertility: An Italian study

  2011cites this paper
• Assays Used in the Study of Sperm Nuclear Proteins

  2011cites this paper
• Clinical Application of Sperm Chromatin Structure Assessment in Andrology Patients

  2011cites this paper
• Sex-sorted bovine spermatozoa and DNA damage: I. Static features.

  2011cites this paper
• Osteoconductive protamine-based polyelectrolyte multilayer functionalized surfaces.

  2011cites this paper
• The clinical utility of the protamine 1/protamine 2 ratio in sperm.

  2011cites this paper
• Sex-sorted bovine spermatozoa and DNA damage: II. Dynamic features.

  2011cites this paper
• Relationships between human sperm protamines, DNA damage and assisted reproduction outcomes.

  2011cites this paper
• Dynamics of sperm DNA fragmentation in patients carrying structurally rearranged chromosomes.

  2011cites this paper
• Epigenetics, spermatogenesis and male infertility.

  2011cites this paper
• Male Subfertility and Sperm Chromatin Damage

  2011cites this paper
• Spermatogenesis: An Overview

  2011cites this paper
• Medical Implications of Sperm Nuclear Quality

  2011cites this paper
• The Emerging Role of the Sperm Epigenome and its Potential Role in Development

  2011cites this paper
• Sperm DNA: organization, protection and vulnerability: from basic science to clinical applications--a position report.

  2010cites this paper
• A common haplotype of protamine 1 and 2 genes is associated with higher sperm counts.

  2010cites this paper
• Toxicants and human sperm chromatin integrity.

  2010cites this paper
• On the possible origins of DNA damage in human spermatozoa.

  2010cites this paper
• Sperm cell proteomics

  2009cites this paper
• Sperm Chromatin Integrity: Etiologies and Mechanisms of Abnormality, Assays, Clinical Importance, Preventing and Repairing Damage

  2009cites this paper
• Spermatozoal RNAs: What about their functions?

  2009cites this paper
• Development Of High Throughput Epigenomic Profiling Technologies And Their Application To Twin Based DNA Methylation Studies

  2009cites this paper
• Florence-Utah Symposium corner: from genetics to epigenetics of male infertility.

  2008cites this paper