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Applying Analytics to Design Lung Transplant Allocation Policy

Theodore Papalexopoulos,James Alcorn,Dimitris Bertsimas,Rebecca Goff,Darren E. Stewart,Nikolaos Trichakis

Published 2023 in INFORMS J. Appl. Anal.

ABSTRACT

In 2019, the United Network for Sharing (UNOS), which has been operating the Organ Procurement and Transplantation Network (OPTN) in the United States since 1984, was seeking to design a new national lung transplant allocation policy. The goal was to develop a point system that would prioritize candidates on the waiting list in a way that would yield more efficient and equitable outcomes. Our joint Massachusetts Institute of Technology (MIT)/UNOS team joined forces with the OPTN Lung Transplantation Committee in these policy design efforts. We discuss how our team applied a novel analytical framework, which was developed at MIT and utilizes optimization, regression, and simulation techniques, to illuminate salient trade-offs among outcomes and guide the choice of how to weigh different point attributes in the allocation formula. The committee selected for the allocation formula weights that were highlighted in the team’s analysis. The team’s proposal was implemented as the national lung allocation policy on March 9, 2023 across the United States. History: This paper has been accepted for the INFORMS Journal on Applied Analytics Special Issue—2022 Daniel H. Wagner Prize for Excellence in the Practice of Advanced Analytics and Operations Research.

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