Impact of the Pro12Ala polymorphism of the PPAR-gamma2 gene on serum triacylglycerol response to n-3 fatty acid supplementation.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular Genetics and Metabolism

• Publication date

  2003-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S1096-7192(03)00065-9PMID 12765846
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 (PPARgamma2) is associated with higher levels of total cholesterol and LDL-cholesterol in male caucasian type 2 diabetes patients.

  2002cited by this paper
• The hormone‐sensitive lipase i6 gene polymorphism and body fat accumulation

  2002cited by this paper
• Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype.

  2002cited by this paper
• Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma.

  2002cited by this paper
• Association Between the PPARA L162V Polymorphism and Plasma Lipid Levels: The Framingham Offspring Study

  2002cited by this paper
• The proline 12 alanine substitution in the peroxisome proliferator--activated receptor-gamma2 gene is associated with lower lipoprotein lipase activity in vivo.

  2002cited by this paper
• Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.

  2002cited by this paper
• Blood Lipid and Lipoprotein Adaptations to Exercise

  2001cited by this paper
• Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells*

  2001cited by this paper
• A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity.

  2001cited by this paper
• The pleiotropic functions of peroxisome proliferator-activated receptor γ

  2001cited by this paper
• The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.

  2001cited by this paper
• A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-gamma 2 is associated with combined hyperlipidaemia in obesity.

  2001cited by this paper
• Consequences of complexity within biological networks: robustness and health, or vulnerability and disease.

  2001cited by this paper
• Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU study

  2001cited by this paper
• Evidence for Gene-Nutrient Interaction at the PPARγ Locus

  2001cited by this paper
• Evidence for gene-nutrient interaction at the PPARgamma locus.

  2001cited by this paper
• Effect of dietary carbohydrate on triglyceride metabolism in humans.

  2001cited by this paper
• Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome.

  2001cited by this paper
• APOE polymorphism and the hypertriglyceridemic effect of dietary sucrose.

  2001cited by this paper
• Modifier genes convert "simple" Mendelian disorders to complex traits.

  2000cited by this paper
• Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism.

  2000cited by this paper
• The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.

  2000cited by this paper
• Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-gamma 2 on thiazolidinedione-induced adipogenesis.

  2000cited by this paper
• Impact of the Peroxisome Proliferator Activated Receptor γ2 Pro12Ala polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus

  2000cited by this paper
• Phenotypes of patients with "simple" Mendelian disorders are complex traits: thresholds, modifiers, and systems dynamics.

  2000cited by this paper
• Context-dependent and invariant associations between APOE genotype and levels of lipoproteins and risk of ischemic heart disease: a review.

  2000cited by this paper
• The genetics of serum lipid responsiveness to dietary interventions

  1999cited by this paper
• Monogenic traits are not simple: lessons from phenylketonuria.

  1999cited by this paper
• Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.

  1999cited by this paper
• The quantitation of lipoprotein lipase mRNA in biopsies of human adipose tissue, using the polymerase chain reaction, and the effect of increased consumption of n-3 polyunsaturated fatty acids

  1999cited by this paper
• A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity

  1998cited by this paper
• Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation.

  1998cited by this paper
• Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein*

  1998cited by this paper
• Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations.

  1998cited by this paper
• Human peroxisome proliferator-activated receptor-gamma2: genetic mapping, identification of a variant in the coding sequence, and exclusion as the gene responsible for lipoatrophic diabetes.

  1998cited by this paper
• n-3 fatty acids and serum lipoproteins: human studies.

  1997cited by this paper
• Molecular Scanning of the Human Peroxisome Proliferator Activated Receptor γ (hPPARγ) Gene in Diabetic Caucasians: Identification of a Pro12Ala PPARγ2 Missense Mutation

  1997cited by this paper
• The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene*

  1997cited by this paper
• Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

  1997cited by this paper
• Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

  1997cited by this paper
• Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation.

  1997cited by this paper
• n-3 fatty acids and serum lipoproteins: animal studies.

  1997cited by this paper
• Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay.

  1997cited by this paper
• The structure - Activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones

  1996cited by this paper
• The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones.

  1996cited by this paper
• PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

  1996cited by this paper
• Tietz textbook of Clinical Chemistry

  1994cited by this paper
• Enzyme immunoassay for intact human insulin in serum or plasma.

  1993cited by this paper
• Determination by PCR-RFLP of apo E genotype in a Japanese population.

  1993cited by this paper
• Reduced Sample Number for Calculation of Insulin Sensitivity and Glucose Effectiveness From the Minimal Model: Suitability for Use in Population Studies

  1993cited by this paper
• Effects of fish oil on VLDL triglyceride kinetics in humans.

  1990cited by this paper
• MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test.

  1986cited by this paper
• Comparison of different analytical and precipitation methods for direct estimation of serum high-density lipoprotein cholesterol.

  1981cited by this paper
• Separation of serum high-density lipoprotein for cholesterol determination: ultracentrifugation vs precipitation with sodium phosphotungstate and magnesium chloride.

  1981cited by this paper
• [A glucose dehydrogenase for the determination of glucose concentrations in body fluids (author's transl)].

  1975cited by this paper
• Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

  1972cited by this paper
• Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor

  1969cited by this paper
• Study of the Relationship Between Glucose and Insulin Responses to an Oral Glucose Load in Man

  1968cited by this paper

• Exploring the link between fibrates therapy and diabetes mellitus following primary acute pancreatitis with hypertriglyceridemia.

  2025cites this paper
• Fish oil supplementation modifies the associations between genetically predicted and observed concentrations of blood lipids: a cross-sectional gene-diet interaction study in UK Biobank

  2024cites this paper
• Omega-3 fatty acids and individual variability in plasma triglyceride response: A mini-review

  2023cites this paper
• Fish oil supplementation modifies the genetic potential for blood lipids

  2023cites this paper
• Nutrigenetics, omega-3 and plasma lipids/lipoproteins/apolipoproteins with evidence evaluation using the GRADE approach: a systematic review

  2022cites this paper
• Clinical Practice Guidelines Using GRADE and AGREE II for the Impact of Genetic Variants on Plasma Lipid/Lipoprotein/Apolipoprotein Responsiveness to Omega-3 Fatty Acids

  2022cites this paper
• Nutrigenetics and nutrigenomics-A personalized approach to nutrition.

  2021cites this paper
• Gene-Diet Interactions and Cardiovascular Diseases

  2020cites this paper
• Peroxisome Proliferator-Activated Receptors and Caloric Restriction—Common Pathways Affecting Metabolism, Health, and Longevity

  2020cites this paper
• Effect of thermal and nutritional conditions on fatty acid metabolism and oxidative stress response in juvenile European sea bass (Dicentrarchus labrax)

  2020cites this paper
• Peroxisome Proliferator-Activated Receptors as Molecular Links between Caloric Restriction and Circadian Rhythm

  2020cites this paper
• Does polymorphisms in PPAR and APOE genes modify associations between fatty acid desaturase (FADS), n-3 long-chain PUFA and cardiometabolic markers in 8–11-year-old Danish children?

  2020cites this paper
• FADS and PPARG2 Single Nucleotide Polymorphisms are Associated with Plasma Lipids in 9-Mo-Old Infants.

  2019cites this paper
• Comparing the serum TAG response to high-dose supplementation of either DHA or EPA among individuals with increased cardiovascular risk: the ComparED study

  2019cites this paper
• Genetic Risk Score Predictive of the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation in a Mexican Population

  2019cites this paper
• Replication of a Gene-Diet Interaction at CD36, NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial☆

  2018cites this paper
• PPARγ Pro12Ala Polymorphism Influences the Relationship between Dietary Fat Intake, Adiposity and Lipid Profile in Patients with Type 2 Diabetes.

  2018cites this paper
• The Impact of Common Gene Variants on EPA and DHA Status and Responsiveness to Increased Intakes

  2018cites this paper
• Plasma Triglyceride Levels May Be Modulated by Gene Expression of IQCJ, NXPH1, PHF17 and MYB in Humans

  2017cites this paper
• Improvement of cardiometabolic markers after fish oil intervention in young Mexican adults and the role of PPARα L162V and PPARγ2 P12A.

  2017cites this paper
• Mining microbiota signatures in human intestinal tract metagenomes

  2016influential citation
• Novel Genetic Loci Associated with the Plasma Triglyceride Response to an Omega-3 Fatty Acid Supplementation

  2016cites this paper
• The integration of epigenetics and genetics in nutrition research for CVD risk factors

  2016influential citation
• Nutrigenetika i prevencija metaboličkog sindroma

  2016cites this paper
• Génétique, acides gras oméga-3 et facteurs de risque des maladies cardiovasculaires

  2015cites this paper
• Effects on metabolic markers are modified by PPARG2 and COX2 polymorphisms in infants randomized to fish oil

  2014cites this paper
• Personalized nutrition and cardiovascular disease prevention: From Framingham to PREDIMED.

  2014cites this paper
• Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation[S]

  2014cites this paper
• Peroxisome Proliferator-Activated Receptors: Biological and Toxicological Importance

  2014cites this paper
• Regulation of Tissue LC-PUFA Contents, Δ6 Fatty Acyl Desaturase (FADS2) Gene Expression and the Methylation of the Putative FADS2 Gene Promoter by Different Dietary Fatty Acid Profiles in Japanese Seabass (Lateolabrax japonicus)

  2014cites this paper
• of the IUNS 20 th Congress of Nutrition Personalized Nutrition and Cardiovascular Disease Prevention : From Framingham to PREDIMED 1 – 3

  2014cites this paper
• The impact of fish‐oil fatty acids on postprandial vascular reactivity (959.22)

  2014influential citation
• Association between erythrocyte membrane fatty acids and biomarkers of dyslipidemia in the EPIC-Potsdam study

  2014cites this paper
• Genetic Variation and Nutrient Metabolism

  2012cites this paper
• Long-chain n23 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized

  2012cites this paper
• Long-chain n-3 PUFAs reduce adipose tissue and systemic inflammation in severely obese nondiabetic patients: a randomized controlled trial.

  2012cites this paper
• Investigation of the relationship between genetic and environmental risk factors associated with obesity and insulin resistance in South African patients with non-alcoholic fatty liver disease (NAFLD)

  2012cites this paper
• Dietary, genetic and metabolic determinants of serum adiponectin

  2012cites this paper
• Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids.

  2012cites this paper
• Interaction of PPAR-γ 2 gene Pro 12 Ala single nucleotide polymorphism with dietary intake of fatty acids in determination of plasma lipids in subjects at cardiometabolic risk

  2012cites this paper
• Gene–Diet Interactions on Lipid Levels: Current Knowledge in the Era of Genome-Wide Association Studies

  2012cites this paper
• Nutrigenomics and nutrigenetics of ω3 polyunsaturated fatty acids.

  2012cites this paper
• Interactions between dietary n-3 fatty acids and genetic variants and risk of disease

  2012cites this paper
• Diet, Genetics, and Disease: A Focus on the Middle East and North Africa Region

  2012cites this paper
• Change in Nutrition and Lifestyle in the Eastern Mediterranean Region: Health Impact

  2012cites this paper
• Nutritional genomics for the characterization of the effect of bioactive molecules in lipid metabolism and related pathways

  2012cites this paper
• Nutrigenomics: A Possible Road to Personalized Nutrition

  2011cites this paper
• Effect of interaction between PPARG, PPARA and ADIPOQ gene variants and dietary fatty acids on plasma lipid profile and adiponectin concentration in a large intervention study

  2011cites this paper
• Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men

  2011cites this paper
• Effects of peroxisome proliferator activated receptor-gamma 2 gene Pro12Ala polymorphism on fasting blood lipids: a meta-analysis.

  2011cites this paper
• Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk[S]

  2011cites this paper
• The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes.

  2011cites this paper
• Host Genotype and the Effect on Microbial Communities

  2011cites this paper
• Association of serum lipid/lipoprotein with Pro12Ala polymorphism in PPAR-γ2 among Chinese nonagenarians/centenarians.

  2011cites this paper
• Metagenomics of the human body

  2011cites this paper
• Fatty acid-genotype interactions and cardiovascular risk.

  2010cites this paper
• Nutrigenetics: a tool to provide personalized nutritional therapy to the obese.

  2010cites this paper
• Meta-analysis The Ala allele in the PPAR- g 2 gene is associated with reduced risk of type 2 diabetes mellitus in Caucasians and improved insulin sensitivity in overweight subjects

  2010cites this paper
• Beneficial Effects of Olive Oil Compared with Fish, Canola, Palm and Soybean Oils on Cardiovascular and Renal Adverse Remodeling due to Hypertension and Diabetes in Rat

  2010cites this paper
• The Ala allele in the PPAR-gamma2 gene is associated with reduced risk of type 2 diabetes mellitus in Caucasians and improved insulin sensitivity in overweight subjects.

  2010cites this paper
• Interaction between diets, polymorphisms and plasma lipid levels

  2010cites this paper
• Nutrigenetics: A Tool to Provide Personalized Nutritional Therapy to the Obese

  2010cites this paper
• Genetic analyses of type 2 diabetes related metabolic risk factors : a twin study

  2009cites this paper
• N-3 fatty acids in glucose metabolism and insulin sensitivity.

  2009cites this paper
• Revisión N-3 fatty acids in glucose metabolism and insulin sensitivity

  2009cites this paper
• Nutrient gene interactions in lipid metabolism

  2009cites this paper
• Personalized nutrition for the prevention of cardiovascular disease: a future perspective.

  2008cites this paper
• The Pro12Ala polymorphism of the PPAR-γ2 gene affects associations of fish intake and marine n−3 fatty acids with glucose metabolism

  2008cites this paper
• Symposium on ‘ Diet and CVD ’ Nutrigenetics and CVD : what does the future hold ?

  2008cites this paper
• PPARgamma2 Pro12Ala polymorphism in relation to free fatty acids concentration and composition in lean healthy Czech individuals with and without family history of diabetes type 2.

  2008cites this paper
• Nutrigenetics and CVD: what does the future hold?

  2008cites this paper
• Allelic variation in ApoC3, ApoA5 and LPL genes and first and second generation antipsychotic effects on serum lipids in patients with schizophrenia

  2008cites this paper
• Gene-lifestyle interaction on risk of type 2 diabetes.

  2007cites this paper
• Pro12Ala polymorphism of the PPARgamma2 locus modulates the relationship between energy intake and body weight in type 2 diabetic patients.

  2007cites this paper
• P RO 12A LA POLYMORPHISM OF THE PPAR γ 2 LOCUS MODULATES THE RELATIONSHIP BETWEEN ENERGY INTAKE AND BODY WEIGHT IN TYPE 2 DIABETIC PATIENTS

  2007cites this paper
• The Pro12Ala Polymorphism in PPARγ2 Gene Affects Lipid Parameters in Greek Primary School Children: A Case of Gene-to-Gender Interaction

  2007cites this paper
• PPARγ and human metabolic disease

  2006cites this paper
• Association of Pro12Ala Polymorphism in Peroxisome Proliferator–Activated Receptor γ With Pre-Diabetic Phenotypes

  2006cites this paper
• Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids

  2006cites this paper
• Molecular mechanisms involved in the regulation of lipid and lipoprotein metabolism by fish oil

  2006cites this paper
• Triglycerides and Risk for Atherosclerotic Disease

  2006cites this paper
• PPAR gamma and human metabolic disease.

  2006cites this paper
• SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors.

  2005cites this paper
• Nutrient-gene interactions contributing to the development of obesity

  2005cites this paper
• Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection.

  2005cites this paper
• [Dietary fatty acids and cancer: potential cellular and molecular mechanisms].

  2005cites this paper
• Gene-diet interaction in relation to the prevention of obesity and type 2 diabetes: evidence from the Finnish Diabetes Prevention Study.

  2005cites this paper
• Nutrigenomics and nutrigenetics

  2004cites this paper
• 10 – Nutrient-gene interactions in the control of obesity

  2004cites this paper
• Effects of long-term intake of edible oils on hypertension and myocardial and aortic remodelling in spontaneously hypertensive rats

  2004cites this paper
• Insulin resistance syndrome (metabolic syndrome) and obesity in Asian Indians: evidence and implications.

  2004cites this paper
• Using humans to study the physiological evolution of energy metabolism: a tribute to Peter Hochachka.

  2004cites this paper
• Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology.

  2004cites this paper
• Exploring the link between fibrates therapy and diabetes mellitus following primary acute pancreatitis with hypertriglyceridemia

  year unknowncites this paper
• Preventing Vascular Disease by Combating LDL Oxidation and Chronic Inflammatory Reactions

  year unknowncites this paper