Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Developmental Dynamics

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/dvdy.22078PMID 19705443PMCID PMC2826787
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

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  2009cited by this paper
• Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis.

  2008cited by this paper
• Drug discovery approaches targeting the PI3K/Akt pathway in cancer

  2008cited by this paper
• Lymphatic Vasculature Development

  2008influential reference
• Lymphatic development in mouse small intestine

  2007influential reference
• The Origin and Development of the Lymphatic System

  2007cited by this paper
• T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling.

  2007cited by this paper
• Novel biochemical pathways of endoglin in vascular cell physiology

  2007cited by this paper
• Endoglin is required for myogenic differentiation potential of neural crest stem cells.

  2007cited by this paper
• Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.

  2007cited by this paper
• Lymphatic endothelium‐specific hyaluronan receptor LYVE‐1 is expressed by stabilin‐1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: implications for the assessment of lymphangiogenesis

  2006cited by this paper
• The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

  2006cited by this paper
• Phosphoinositide 3-kinases as drug targets in cancer.

  2005cited by this paper
• Vasculogenesis and angiogenesis in the mouse embryo studied using quail/mouse chimeras.

  2005cited by this paper
• PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature.

  2005influential reference
• Interaction and functional interplay between endoglin and ALK‐1, two components of the endothelial transforming growth factor‐β receptor complex

  2005cited by this paper
• Activation of Vascular Endothelial Growth Factor Receptor-3 and Its Downstream Signaling Promote Cell Survival under Oxidative Stress*

  2004cited by this paper
• Functional significance of Tie2 signaling in the adult vasculature.

  2004cited by this paper
• Vascular Endothelial Growth Factor Activates PI3K/Akt/Forkhead Signaling in Endothelial Cells

  2004cited by this paper
• p50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity

  2004cited by this paper
• Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins

  2004influential reference
• Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation.

  2004cited by this paper
• Vasculogenesis and angiogenesis.

  2004cited by this paper
• Lymphatic vasculature development

  2004cited by this paper
• Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

  2004influential reference
• An electron microscopic study of the central lacteal in the intestinal villus of the cat

  2004cited by this paper
• p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity.

  2004cited by this paper
• Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor.

  2003influential reference
• [Vasculogenesis and angiogenesis].

  2003cited by this paper
• Genesis and pathogenesis of lymphatic vessels

  2003influential reference
• Transcriptional activation of endoglin and transforming growth factor-beta signaling components by cooperative interaction between Sp1 and KLF6: their potential role in the response to vascular injury.

  2002influential reference
• Insulin and TNF alpha induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK 1/2-dependent pathways.

  2002cited by this paper
• Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

  2002cited by this paper
• Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3

  2001cited by this paper
• Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase

  2001cited by this paper
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  2001influential reference
• Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

  2000influential reference
• Endoglin Is Overexpressed After Arterial Injury and Is Required for Transforming Growth Factor-&bgr;–Induced Inhibition of Smooth Muscle Cell Migration

  2000cited by this paper
• Endoglin, a TGF-beta receptor-associated protein, is expressed by smooth muscle cells in human atherosclerotic plaques.

  2000cited by this paper
• Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

  1999cited by this paper
• Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1.

  1999cited by this paper
• Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors.

  1998influential reference
• Cloning of the Promoter Region of Human Endoglin, the Target Gene for Hereditary Hemorrhagic Telangiectasia Type 1

  1998cited by this paper
• Cloning of the promoter region of human endoglin, the target gene for hereditary hemorrhagic telangiectasia type 1.

  1998cited by this paper
• Remodeling and neointimal formation in the carotid artery of normal and P-selectin-deficient mice.

  1997cited by this paper
• Endoglin modulates cellular responses to TGF-beta 1

  1996cited by this paper
• Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1

  1994cited by this paper
• Gastropathies in the Lundehund

  1994cited by this paper
• Gastropathies in the Lundehund. I. Gastritis and gastric neoplasia associated with intestinal lymphangiectasia.

  1994cited by this paper

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• Current Thoughts on Burn Resuscitation.

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  2024cites this paper
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  2022cites this paper
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  2021cites this paper
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  2020cites this paper
• The immuno-oncological implications of insulin.

  2020cites this paper
• Lymphatic Valves and Lymph Flow in Cancer-Related Lymphedema

  2020cites this paper
• Ras Pathways on Prox1 and Lymphangiogenesis: Insights for Therapeutics

  2020cites this paper
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  2019cites this paper
• Cytokines regulating lymphangiogenesis.

  2018cites this paper
• Intestinal lymphatic vasculature: structure, mechanisms and functions

  2017cites this paper
• Rapamycin reversal of VEGF-C-driven lymphatic anomalies in the respiratory tract.

  2017cites this paper
• The Journal of Clinical Investigation

  2016cites this paper
• Heterogeneity in the lymphatic vascular system and its origin

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Somatic PIK3CA mutations as a driver of sporadic venous malformations

  2016cites this paper
• DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport.

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2011cites this paper
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  2010cites this paper
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  2010cites this paper
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  2010cites this paper