Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Carcinogenesis

• Publication date

  2003-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/CARCIN/24.3.527PMID 12663514
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China.

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• Supplemental dietary calcium fails to alter the acute effects of 1,2-dimethylhydrazine on O6-methylguanine, O6-alkylguanine-DNA alkyltransferase and cellular proliferation in the rat colon.

  1993influential reference
• DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment.

  1992cited by this paper
• A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel.

  1992cited by this paper
• Dietary calcium does not reduce experimental colorectal carcinogenesis after small bowel resection despite reducing cellular proliferation.

  1992cited by this paper
• Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose-response study.

  1991cited by this paper
• Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

  1990cited by this paper
• Target tissue DNA damage in inbred mouse strains with different susceptibility to the colon carcinogen 1,2-dimethylhydrazine.

  1988cited by this paper
• Cellular proliferation in proximal and distal rat colon during 1,2-dimethylhydrazine-induced carcinogenesis.

  1988cited by this paper
• Differential susceptibility of rat and guinea pig colon mucosa DNA to methylation by methylazoxymethyl acetate in vivo.

  1985cited by this paper
• Differential susceptibility of inbred mouse strains forecast by acute colonic proliferative response to methylazoxymethanol.

  1984cited by this paper
• Histogenesis of colon cancer in experimental animals.

  1984cited by this paper
• Histogenesis of colon cancer in experimental animals.

  1984cited by this paper
• Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/Ha mice given 1,2-dimethylhydrazine.

  1983cited by this paper
• Experimental Colon Carcinogenesis

  1983cited by this paper
• Strain differences in susceptibility of female mice to 1,2-dimethylhydrazine.

  1982cited by this paper
• DNA methylation during chronic administration of 1,2-dimethylhydrazine in a carcinogenic regimen.

  1982cited by this paper
• In vivo kinetics of O6-methylguanine and 7-methylguanine formation and persistence in DNA of rats treated with symmetrical dimethylhydrazine.

  1981cited by this paper
• 1,2-Dimethylhydrazine-induced methylation of DNA bases in various rat organs and the effect of pretreatment with disulfiram.

  1979cited by this paper
• DNA alkylation in mice with genetically different susceptibility to 1,2-dimethylhydrazine-induced colon carcinogenesis.

  1978cited by this paper
• Genetic Differences in the Induction of Colorectal Tumors by 1,2-Dimethylhydrazine in Inbred Mice

  1977cited by this paper
• Differential susceptibility of four mouse strains to induction of multiple large-bowel neoplasms by 1,2-dimethylhydrazine.

  1974cited by this paper
• Brief Communication: Differential Susceptibility of Four Mouse Strains to Induction of Multiple Large-Bowel Neoplasms by 1,2-Dimethylhydrazine

  1974cited by this paper

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  2017influential citation
• Impact of DNA repair on the dose-response of colorectal cancer formation induced by dietary carcinogens.

  2017cites this paper
• Chemopreventive effect of carvacrol on 1,2-dimethylhydrazine induced experimental colon carcinogenesis.

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