(-)-Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high-fat diet.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Nutrition & Food Research

• Publication date

  2017-11-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/mnfr.201700303PMID 28734036
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The potential of flavonoids in the treatment of non-alcoholic fatty liver disease

  2017cited by this paper
• A simple practice guide for dose conversion between animals and human

  2016cited by this paper
• LPS-induced renal inflammation is prevented by (−)‐epicatechin in rats

  2016cited by this paper
• A randomized, placebo-controlled, double-blind study on the effects of (-)-epicatechin on the triglyceride/HDLc ratio and cardiometabolic profile of subjects with hypertriglyceridemia: Unique in vitro effects.

  2016cited by this paper
• Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs.

  2016cited by this paper
• The Impact of Cocoa Flavanols on Cardiovascular Health

  2016cited by this paper
• The protective effect of epicatechin on experimental ulcerative colitis in mice is mediated by increasing antioxidation and by the inhibition of NF-κB pathway

  2016cited by this paper
• Alpha‐boswellic acid protects against ethanol‐induced gastric injury in rats: involvement of nuclear factor erythroid‐2‐related factor 2/heme oxygenase‐1 pathway

  2016cited by this paper
• Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice.

  2016cited by this paper
• Effect of Hibiscus sabdariffa extract on high fat diet–induced obesity and liver damage in hamsters

  2015cited by this paper
• Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice

  2015cited by this paper
• Hyperlipidemia in Early Adulthood Increases Long-Term Risk of Coronary Heart Disease

  2015cited by this paper
• Supplementation of the Pure Flavonoids Epicatechin and Quercetin Affects Some Biomarkers of Endothelial Dysfunction and Inflammation in (Pre)Hypertensive Adults: A Randomized Double-Blind, Placebo-Controlled, Crossover Trial.

  2015cited by this paper
• Non-alcoholic fatty liver disease: The diagnosis and management.

  2015cited by this paper
• Cardiovascular Benefits of Dark Chocolate?

  2015cited by this paper
• Non-alcoholic fatty liver disease: The diagnosis and management

  2015cited by this paper
• High-Fat Diet-Induced Adiposity, Adipose Inflammation, Hepatic Steatosis and Hyperinsulinemia in Outbred CD-1 Mice

  2015cited by this paper
• Molecular Mechanisms and Therapeutic Effects of (−)-Epicatechin and Other Polyphenols in Cancer, Inflammation, Diabetes, and Neurodegeneration

  2015cited by this paper
• High Fatty Diet Effects on Rat Liver

  2014cited by this paper
• The effect of green tea on blood pressure and lipid profile: a systematic review and meta-analysis of randomized clinical trials.

  2014cited by this paper
• Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic.

  2014cited by this paper
• Abstract 441: Epicatechin Attenuates Atherosclerosis and Exerts Anti-inflammatory Effects on Diet-Induced Human CRP and NfκB in vivo

  2014cited by this paper
• Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation.

  2014cited by this paper
• Nutraceuticals and Functional Foods in the Management of Hyperlipidemia

  2014cited by this paper
• Effects of (-)-epicatechin on a diet-induced rat model of cardiometabolic risk factors.

  2014cited by this paper
• Green and black tea for the primary prevention of cardiovascular disease.

  2013cited by this paper
• (–)‐Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO‐mediated mechanism

  2013cited by this paper
• Cocoa and human health.

  2013cited by this paper
• Hyperlipidemia as a risk factor for cardiovascular disease.

  2013cited by this paper
• High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.

  2012cited by this paper
• Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy.

  2012cited by this paper
• Green tea extract suppresses NFκB activation and inflammatory responses in diet-induced obese rats with nonalcoholic steatohepatitis.

  2012cited by this paper
• Effects of catechin and epicatechin on superoxide dismutase and glutathione peroxidase activity, in vivo

  2012cited by this paper
• Epicatechin: endothelial function and blood pressure.

  2012cited by this paper
• Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials.

  2012cited by this paper
• Green tea catechins decrease total and low-density lipoprotein cholesterol: a systematic review and meta-analysis.

  2011cited by this paper
• SIRT1 as a potential therapeutic target for treatment of nonalcoholic fatty liver disease

  2011cited by this paper
• Effects of cocoa products/dark chocolate on serum lipids: a meta-analysis

  2011cited by this paper
• Pharmacologic treatment of hyperlipidemia.

  2011cited by this paper
• Flavonoid-rich cocoa consumption affects multiple cardiovascular risk factors in a meta-analysis of short-term studies.

  2011cited by this paper
• Inflammatory markers in hyperlipidemia: from experimental models to clinical practice.

  2011cited by this paper
• The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; a systematic review.

  2010cited by this paper
• Implications of diet on nonalcoholic fatty liver disease

  2010cited by this paper
• SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*

  2010cited by this paper
• Specific Dietary Polyphenols Attenuate Atherosclerosis in Apolipoprotein E–Knockout Mice by Alleviating Inflammation and Endothelial Dysfunction

  2010cited by this paper
• SREBP-1c in nonalcoholic fatty liver disease induced by Western-type high-fat diet plus fructose in rats.

  2009cited by this paper
• Increasing Oxidative Stress with Progressive Hyperlipidemia in Human: Relation between Malondialdehyde and Atherogenic Index

  2008cited by this paper
• SREBPs: sterol-regulated transcription factors.

  2006cited by this paper
• Defining high-fat-diet rat models: metabolic and molecular effects of different fat types.

  2006cited by this paper
• (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.

  2006cited by this paper
• Hyperlipidemia and cardiovascular disease.

  2006cited by this paper
• SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

  2002cited by this paper
• Succinate dehydrogenase and human diseases: new insights into a well-known enzyme

  2002cited by this paper
• Role of LXRs in control of lipogenesis.

  2000cited by this paper
• Hyperlipidemia and cardiovascular disease.

  1998cited by this paper
• Hyperlipidemia and cardiovascular disease.

  1997cited by this paper

• Functional Crackers Enriched with Chia, Sweet Potato, Banana, and Almond Mitigate Diet-Induced Hyperlipidemia and Oxidative Stress, Reducing Cardiovascular Disease Risk

  2026cites this paper
• Polyphenol profile matters: complementary contribution of extractable and non-extractable polyphenols over metabolic effects of beverage byproducts blends.

  2026cites this paper
• Modulation of molecular and serological biomarkers by (-)-epicatechin consumption on a murine model of metabolic dysfunction-associated steatotic liver disease.

  2025cites this paper
• The role of GPER-mediated AMPKα signal in the prevention effect of (-)-epicatechin on metabolic dysfunction-associated steatohepatitis.

  2025cites this paper
• (-)Epicatechin targets early growth response protein 1, an inflammation-associated ferroptosis regulator, to ameliorate metabolic dysfunction-associated steatotic liver disease.

  2025cites this paper
• Lack of Beneficial Effects of Epicatechin in Obese Male and Female Mice

  2025cites this paper
• Multifaceted roles of herbal compounds in dyslipidemia management: Mechanistic and therapeutic perspectives of herbal medicine

  2025cites this paper
• Interaction of Programmed Obesity and Postnatal High Fat Diet but Not (-)-Epicatechin Treatment Modifies Muscle Atrophy Proteins Levels in Male Wistar Rats

  2025cites this paper
• Effects of Epicatechin on the Expression of MyomiRs−31, −133, −136, −206, −296, and −486 in the Skeletal Muscle of the Offspring of Obese Mothers

  2025cites this paper
• Bioinformatics Examination of Quercetin from Salacca zalacca Skin, Fruit, and Seed as a Potent Active Compounds Against Hypercholesterolemia Via PCSK9 Inhibition

  2025cites this paper
• Hepatocyte-Targeted Epicatechin Nanoparticles Promote Autophagy and Enhance Mitochondrial Function in Metabolic Dysfunction-Associated Steatotic Liver Disease

  2025cites this paper
• (−)-Epigallocatechin-3-O-gallate or (−)-epicatechin enhances lipid catabolism and antioxidant defense in common carp (Cyprinus carpio L.) fed a high-fat diet: Mechanistic insights from the AMPK/Sirt1/PGC-1α signaling pathway

  2024cites this paper
• The Role of Dietary Ingredients and Herbs in the Prevention of Non-Communicable Chronic Liver Disease

  2024cites this paper
• Therapeutic Potential of Nutraceuticals against Drug-Induced Liver Injury

  2024cites this paper
• (−)-Epicatechin treatment modify the expression of genes related to atrophy in gastrocnemius muscle of male rats obese by programing

  2024cites this paper
• Epicatechin: Potential Use as Anti-Obese and Anti-Periodontal Nutrient

  2024cites this paper
• The associations between dietary flavonoid intake and hyperlipidemia: data from the national health and nutrition examination survey 2007–2010 and 2017–2018

  2024cites this paper
• Autoclaving-treated germinated brown rice relieves hyperlipidemia by modulating gut microbiota in humans

  2024cites this paper
• Effects of Crataegus orientalis fruit extract on lipid accumulation in oleic acid-induced HepG2 cells

  2024cites this paper
• Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects

  2024cites this paper
• Microbial Fermentation Enhances the Effect of Black Tea on Hyperlipidemia by Mediating Bile Acid Metabolism and Remodeling Intestinal Microbes

  2024cites this paper
• Uxi (Endopleura uchi (Huber) Cuatrec) bark extract mitigates HFD-induced adiposity in rats via targeting oxidative stress, and lipogenic genes expression

  2024cites this paper
• Testing the Feasibility and Dietary Impact of Macaroni Fortified with Green Tea and Turmeric Curcumin Extract in Diabetic Rats

  2023cites this paper
• Biological Role and Related Natural Products of SIRT1 in Nonalcoholic Fatty Liver

  2023cites this paper
• Comparison of fresh and browning lotus roots (Nelumbo nucifera Gaertn.) on modulating cholesterol metabolism via decreasing hepatic cholesterol deposition and increasing fecal bile acid excretion

  2023cites this paper
• Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization

  2023cites this paper
• To Explore the Mechanism of Hawthorn in the Intervention of Hyperlipidemia Based on the Gene Expression Omnibus and Network Pharmacology

  2023cites this paper
• Chinese herbal medicines: The modulator of nonalcoholic fatty liver disease targeting oxidative stress.

  2023cites this paper
• Enhancement of Biochemical and Genomic Pathways through Lycopene-Loaded Nano-Liposomes: Alleviating Insulin Resistance, Hepatic Steatosis, and Autophagy in Obese Rats with Non-Alcoholic Fatty Liver Disease: Involvement of SMO, GLI-1, and PTCH-1 Genes.

  2023cites this paper
• Unravelling the anti-inflammatory and antioxidant effects of standardized green and black caffeinated coffee, tea, and their mixtures in an obese male rat model: Insights from biochemical, metabolomic, and histopathological analyses.

  2023cites this paper
• Therapeutic potential of bioactive phytoconstituents found in fruits in the treatment of non-alcoholic fatty liver disease: A comprehensive review.

  2023cites this paper
• Polyphenol Profile, Antioxidant Activity, and Hypolipidemic Effect of Longan Byproducts

  2023cites this paper
• Natural products in pursuing novel therapies of nonalcoholic fatty liver disease and steatohepatitis.

  2023cites this paper
• Potential therapeutic effects of green tea on obese lipid profile – a systematic review

  2022cites this paper
• The effects of ethanolic extract of the leaves of Erythroxylum mucronatum (Benth.) (Erythroxylaceae) on strength and muscle performance of resistance trained rats

  2022cites this paper
• Is it possible to treat nonalcoholic liver disease using a flavanol-based nutraceutical approach? Basic and clinical data

  2022cites this paper
• Er-Chen Decoction Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Rats through Remodeling Gut Microbiota and Regulating the Serum Metabolism

  2022cites this paper
• The Effects of High Fat Diet on the Liver of the White Rat Model Obesity

  2022cites this paper
• Research Progress on the Lipid-Lowering and Weight Loss Effects of Tea and the Mechanism of its Functional Components.

  2022cites this paper
• Current innovations in nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease.

  2021cites this paper
• ( −)-Epicatechin and cardiometabolic risk factors: a focus on potential mechanisms of action

  2021influential citation
• Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet

  2021cites this paper
• (-)-Epicatechin Inhibits Cardiac Fibrosis via SIRT1/AKT/GSK3β Pathway

  2021cites this paper
• Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data From a Systematic Review of Animal Studies.

  2021cites this paper
• Ethanol Extract of Amomum tsao-ko Ameliorates Ovariectomy-Induced Trabecular Loss and Fat Accumulation

  2021cites this paper
• Recent Molecular Mechanisms and Beneficial Effects of Phytochemicals and Plant-Based Whole Foods in Reducing LDL-C and Preventing Cardiovascular Disease

  2021cites this paper
• A Novel Herbal Medicine for Dyslipidemia: Assessments in Experimental Models

  2021cites this paper
• Mechanisms Modified by (−)-Epicatechin and Taxifolin Relevant for the Treatment of Hypertension and Viral Infection: Knowledge from Preclinical Studies

  2021cites this paper
• (-)-Epicatechin and the comorbidities of obesity.

  2020cites this paper
• Nutraceutical Properties of Polyphenols against Liver Diseases

  2020cites this paper
• The effect of adiponectin in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the potential role of polyphenols in the modulation of adiponectin signaling.

  2020cites this paper
• Plasma Lipidomics Reveals Insights into Anti-Obesity Effect of Chrysanthemum morifolium Ramat Leaves and Its Constituent Luteolin in High-Fat Diet-Induced Dyslipidemic Mice

  2020cites this paper
• Water Extract of Potentilla discolor Bunge Improves Hepatic Glucose Homeostasis by Regulating Gluconeogenesis and Glycogen Synthesis in High-Fat Diet and Streptozotocin-Induced Type 2 Diabetic Mice

  2020cites this paper
• Hypolipidemic Effect of Cinnamon (Cinnamomum zeylanicum) Bark Ethanolic Extract on Triton X-100 induced Hyperlipidemia in Albino Rats

  2020cites this paper
• Baccaurea ramiflora Lour.: a comprehensive review from traditional usage to pharmacological evidence

  2020cites this paper
• Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

  2020influential citation
• Flavonoids-mediated SIRT1 signaling activation in hepatic disorders.

  2020cites this paper
• (-)-Epicatechin protects thoracic aortic perivascular adipose tissue from whitening in high-fat fed mice.

  2020cites this paper
• Effect of green tea consumption on blood lipids: a systematic review and meta-analysis of randomized controlled trials

  2020cites this paper
• Theaflavin TF3 relieves hepatocyte lipid deposition through activating AMPK signaling pathway by targeting plasma kallikrein.

  2020cites this paper
• OPTO_A_206904 39..45

  2019cites this paper
• Bioactive compounds from herbal medicines to manage dyslipidemia.

  2019cites this paper
• Low doses of cocoa extract supplementation ameliorate diet-induced obesity and insulin resistance in rats.

  2019cites this paper
• Polyunsaturated fatty acids from microalgae Spirulina platensis modulates lipid metabolism disorders and gut microbiota in high-fat diet rats.

  2019cites this paper
• Effects and Mechanisms of Tea and Its Bioactive Compounds for the Prevention and Treatment of Cardiovascular Diseases: An Updated Review

  2019influential citation
• (−)-Epicatechin modifies body composition of the male offspring of obese rats

  2019cites this paper
• Assessment of the tear film in normal eye subjects after consumption of a single dose of hot peppermint drink

  2019cites this paper
• Hepatoprotective effect of coffee pulp aqueous extract combined with simvastatin against hepatic steatosis in high-fat diet-induced obese rats

  2019cites this paper
• Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease.

  2019cites this paper
• Effects of (-)-epicatechin on the time course of the expression of perilipins in a diet-induced model of nonalcoholic steatohepatitis.

  2019cites this paper
• Regulatory Efficacy of Spirulina platensis Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats

  2018cites this paper
• Regulatory Efficacy of the Polyunsaturated Fatty Acids from Microalgae Spirulina platensis on Lipid Metabolism and Gut Microbiota in High-Fat Diet Rats

  2018influential citation
• Enantioselective Synthesis of 4-Amino-3-hydroxybenzopyran Flavanol Derivatives from Chalcones

  2018cites this paper
• Biological activities of (-)-epicatechin and (-)-epicatechin-containing foods: Focus on cardiovascular and neuropsychological health.

  2018cites this paper
• Polygonatum odoratum Polysaccharides Modulate Gut Microbiota and Mitigate Experimentally Induced Obesity in Rats

  2018cites this paper
• Consumption of Green Tea ( Camellia sinensis ) Improves Lipid, Hepatic, and Hematological Profiles of Rats That Are Submitted to Long-Term Androgenic Stimulation

  2018influential citation
• Modulatory Effect of Polyphenolic Compounds from the Mangrove Tree Rhizophora mangle L. on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in High-Fat Diet Obese Mice

  2018cites this paper
• Marsdenia tenacissima extract induces apoptosis and suppresses autophagy through ERK activation in lung cancer cells

  2018cites this paper