The Effect of Giving Vitamin D Supplements on Improving Ejection Fraction in Heart Failure Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia

Background: The role of vitamin D as an inflammation modulator, regulation system renin-angiotensin-aldosterone (RAAS), inhibits the production of parathyroid hormone (PTH), thereby causing left ventricular hypertrophy, causing hypocalcemia which induces hypertrophy in cardiac myocytes and can reduce cardiac contractility. This study aimed to determine the effect of giving vitamin D supplements on improving ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital (RSMH) Palembang, Indonesia. Methods: This study is an experimental study with a double-blind, randomized clinical trial design and uses primary data obtained from clinical examinations and supporting examinations of research subjects. A total of 40 research subjects participated in this study. Results: In this study, the median vitamin D level in the vitamin D supplementation group before treatment was 19.92 ng/dl (18.65-20.22), and in the placebo group was 19.74 ng/dl (18.14 - 20.13). After treatment with 1000 iu of vitamin D given for 3 months, the results showed that in the vitamin D supplementation group, there was an increase in vitamin D levels to 33.06 ng/dl (an increase of 13.14) with statistically significant results (p < 0 .05). In the vitamin D supplementation group, there was an increase in ejection fraction to 37.9% (an increase of 3.65%) with statistically significant results (p<0.05). Contrasting results were shown in the group that received a placebo, where there was a decrease in ejection fraction to 33.15% (2.25% decrease). Conclusion: There is an improving effect of giving vitamin D supplements on increasing ejection fraction in heart failure patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia.

• Publication year

  2023

• Venue

  Bioscientia Medicina : Journal of Biomedicine and Translational Research

• Publication date

  2023-09-28

• Fields of study

  Not labeled

• Identifiers
  DOI 10.37275/bsm.v7i10.869
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Comments on the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure.

  2022cited by this paper
• 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

  2022cited by this paper
• [ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: what's new?]

  2022cited by this paper
• Vitamin D Toxicity: A Clinical Perspective

  2020cited by this paper
• Vitamin D Metabolism and Guidelines for Vitamin D Supplementation.

  2020cited by this paper
• Vitamin D supplementation: upper limit for safety revisited?

  2020cited by this paper
• Correlation of Vitamin D with Inflammatory Cytokines, Atherosclerotic Parameters, and Lifestyle Factors in the Setting of Heart Failure: A 12-Month Follow-Up Study

  2019cited by this paper
• Association between vitamin D and risk of cardiovascular disease in Chinese rural population

  2019cited by this paper
• Role of Vitamin D in Patients with Heart Failure with Reduced Ejection Fraction

  2019cited by this paper
• Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis

  2018cited by this paper
• Association between vitamin D deficiency and heart failure risk in the elderly

  2017cited by this paper
• Role of Vitamin D in Cardiovascular Diseases.

  2017cited by this paper
• Effects of Vitamin D supplementation on physical activity of patients with Heart Failure

  2016cited by this paper
• Effects of Vitamin D on Cardiac Function in Patients With Chronic HF The VINDICATE Study

  2016cited by this paper
• Vitamin D and cardiovascular disease.

  2014cited by this paper
• Vitamin D Deficiency and Diseases

  2014cited by this paper
• Effects of six months of vitamin D supplementation in patients with heart failure: a randomized double-blind controlled trial.

  2014cited by this paper
• Vitamin D and Immune Function

  2013cited by this paper
• Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.

  2011cited by this paper
• Vitamin D biology in heart failure: molecular mechanisms and systematic review.

  2011cited by this paper
• Echocardiography in Heart Failure

  2010cited by this paper
• Vitamin D status: measurement, interpretation, and clinical application.

  2009cited by this paper
• Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography.

  2008cited by this paper
• Vitamin D Deficiency and Risk of Cardiovascular Disease

  2008cited by this paper
• Bioavailability of vitamin D.

  1997cited by this paper
• Annual Review of Medicine.

  1958cited by this paper

• No citing papers are available for this paper.