Dirty-Appearing White Matter: A Disregarded Entity in Multiple Sclerosis

In patients with multiple sclerosis (MS), the term dirty-appearing white matter (DAWM) refers to brain regions of intermediate signal intensity between those of focal lesions and normal-appearing white matter (NAWM) on T2-weighted and proton attenuation–weighted images.[1][1][][2][][3]–[4][4]

• Publication year

  2010

• Venue

  American Journal of Neuroradiology

• Publication date

  2010-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.3174/ajnr.A1834PMID 19833799PMCID PMC7963976
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diffusely Abnormal White Matter in Progressive Multiple Sclerosis: In Vivo Quantitative MR Imaging Characterization and Comparison between Disease Types

  2010cited by this paper
• Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

  2009cited by this paper
• Diffusely abnormal white matter in chronic multiple sclerosis: imaging and histopathologic analysis.

  2009influential reference
• Brain tumor stem cells: bringing order to the chaos of brain cancer.

  2008cited by this paper
• Dirty-appearing white matter in multiple sclerosis

  2008influential reference
• Cancer stem cells in the mammalian central nervous system

  2005cited by this paper
• Radial glia cells are candidate stem cells of ependymoma.

  2005cited by this paper
• Quantification of cervical cord pathology in primary progressive MS using diffusion tensor MRI

  2005cited by this paper
• Dirty-appearing white matter in multiple sclerosis: volumetric MR imaging and magnetization transfer ratio histogram analysis.

  2003influential reference
• Evidence for widespread movement-associated functional MRI changes in patients with PPMS

  2002cited by this paper
• Correlations between Structural CNS Damage and Functional MRI Changes in Primary Progressive MS

  2002cited by this paper
• Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis: a diffusion-tensor magnetic resonance imaging study.

  2002cited by this paper
• Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging.

  2002cited by this paper
• In vivo assessment of the brain and cervical cord pathology of patients with primary progressive multiple sclerosis.

  2001cited by this paper
• Diagnostic criteria for primary progressive multiple sclerosis: A position paper

  2000cited by this paper
• A comparison of magnetization transfer ratio, magnetization transfer rate, and the native relaxation time of water protons related to relapsing-remitting multiple sclerosis.

  2000influential reference
• Axonal transection in the lesions of multiple sclerosis.

  1998cited by this paper
• Axonal damage in acute multiple sclerosis lesions.

  1997cited by this paper

• Validation of a data-driven multicomponent T2 analysis for quantifying myelin content in the cuprizone mouse model of multiple sclerosis

  2025cites this paper
• Detection of diffusely abnormal white matter in multiple sclerosis on multiparametric brain MRI using semi-supervised deep learning

  2024cites this paper
• Myelin Quantification in White Matter Pathology of Progressive Multiple Sclerosis Post-Mortem Brain Samples: A New Approach for Quantifying Remyelination

  2021cites this paper
• Diffusely appearing white matter in multiple sclerosis: Insights from sodium (23Na) MRI.

  2021cites this paper
• Diffusely abnormal white matter in multiple sclerosis

  2021cites this paper
• Assessment of Artificial Intelligence Automatic Multiple Sclerosis Lesion Delineation Tool for Clinical Use

  2021cites this paper
• Normal appearing brain white matter changes in relapsing multiple sclerosis: Texture image and classification analysis in serial MRI scans.

  2020cites this paper
• Pathology-preserving intensity standardization framework for multi-institutional FLAIR MRI datasets.

  2019cites this paper
• Primary Progressive Multiple Sclerosis: Putting Together the Puzzle

  2017cites this paper
• Framework for the Robust Analysis of Neurological FLAIR MRI in Multi-Centre and Multi-Disease Datasets

  2017cites this paper
• Measurement of subtle blood-brain barrier disruption in cerebral small vessel disease using dynamic contrast-enhanced magnetic resonance imaging

  2016cites this paper
• Blood pressure and sodium: Association with MRI markers in cerebral small vessel disease

  2016cites this paper
• On the computational assessment of white matter hyperintensity progression: difficulties in method selection and bias field correction performance on images with significant white matter pathology

  2016cites this paper
• Identification de programmes d'activation macrophagique et microgliale dans les formes progressives de la sclérose en plaques

  2014influential citation
• EXAMINING SINGLE-SUBJECT RELIABILITY OF FUNCTIONAL MAGNETIC RESONANCE IMAGING IN ESTABLISHED MULTIPLE SCLEROSIS

  2014cites this paper
• Tissue remodeling in periplaque regions of multiple sclerosis spinal cord lesions

  2014cites this paper
• Incidental Periventricular White Matter Hyperintensities Revisited: What Detailed Morphologic Image Analyses Can Tell Us

  2014cites this paper
• Morphologic, Distributional, Volumetric, and Intensity Characterization of Periventricular Hyperintensities

  2014cites this paper
• Multi-scale classification of disease using structural MRI and wavelet transform

  2012cites this paper
• HyperintensitiesIntensity Characterization of Periventricular Morphologic, Distributional, Volumetric, and

  year unknowninfluential citation