Potential of β2AR for added benefit in treating heart failure through a better understanding of signaling

No abstract is available for this paper.

• Publication year

  2023

• Venue

  Current Opinion in Physiology

• Publication date

  2023-09-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/j.cophys.2023.100719
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants and antipsychotics for the human α2A, α2B, and α2C‐adrenoceptors and comparison with human α1 and β‐adrenoceptors

  2022cited by this paper
• β-Arrestin–Biased Allosteric Modulator Potentiates Carvedilol-Stimulated β Adrenergic Receptor Cardioprotection

  2021cited by this paper
• The affinity and selectivity of α‐adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D‐adrenoceptors

  2020cited by this paper
• Decellularized Human Dermal Matrix as a Biological Scaffold for Cardiac Repair and Regeneration

  2020cited by this paper
• The Beta3 Adrenergic Receptor in Healthy and Pathological Cardiovascular Tissues

  2020cited by this paper
• The Microenvironment of Decellularized Extracellular Matrix from Heart Failure Myocardium Alters the Balance between Angiogenic and Fibrotic Signals from Stromal Primitive Cells

  2020cited by this paper
• Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?

  2020cited by this paper
• Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling

  2018cited by this paper
• Small-Molecule Positive Allosteric Modulators of the β2-Adrenoceptor Isolated from DNA-Encoded Libraries

  2018cited by this paper
• Beta 2-adrenergic receptor agonists are novel regulators of macrophage activation in diabetic renal and cardiovascular complications.

  2017cited by this paper
• Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling

  2017cited by this paper
• Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts.

  2017cited by this paper
• β-arrestin–biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction

  2016cited by this paper
• Arrhythmogenic Remodeling of &bgr;2 Versus &bgr;1 Adrenergic Signaling in the Human Failing Heart

  2015cited by this paper
• Meta-analysis of the effects of carvedilol versus metoprolol on all-cause mortality and hospitalizations in patients with heart failure.

  2015cited by this paper
• Development and Characterization of Pepducins as Gs-biased Allosteric Agonists*♦

  2014cited by this paper
• Carvedilol induces greater control of β2- than β1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium

  2014cited by this paper
• Regulation of cardiac L-type Ca²⁺ channel CaV1.2 via the β-adrenergic-cAMP-protein kinase A pathway: old dogmas, advances, and new uncertainties.

  2013cited by this paper
• PDE3, but not PDE4, reduces β1‐ and β2‐adrenoceptor‐mediated inotropic and lusitropic effects in failing ventricle from metoprolol‐treated patients

  2013cited by this paper
• ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca2+ and Mg2+ Regulation

  2013cited by this paper
• Cardiac Fibroblast-Derived Extracellular Matrix (Biomatrix) as a Model for the Studies of Cardiac Primitive Cell Biological Properties in Normal and Pathological Adult Human Heart

  2013cited by this paper
• β-Adrenergic receptor expression in vascular tumors

  2012cited by this paper
• Human atrial β1L‐adrenoceptor but not β3‐adrenoceptor activation increases force and Ca2+ current at physiological temperature

  2011cited by this paper
• Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation.

  2011cited by this paper
• &bgr;3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification

  2010cited by this paper
• Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action

  2010cited by this paper
• Ca2+ cycling and new therapeutic approaches for heart failure.

  2010cited by this paper
• The selectivity of β‐adrenoceptor agonists at human β1‐, β2‐ and β3‐adrenoceptors

  2010cited by this paper
• COMPARISON OF SOME PROPERTIES OF PRONETHALOL AND PROPRANOLOL

  2010cited by this paper
• Phosphorylation and function of cardiac myosin binding protein-C in health and disease.

  2010cited by this paper
• Arrhythmogenic Effects of &bgr;2-Adrenergic Stimulation in the Failing Heart Are Attributable to Enhanced Sarcoplasmic Reticulum Ca Load

  2008cited by this paper
• β-Blockers alprenolol and carvedilol stimulate β-arrestin-mediated EGFR transactivation

  2008cited by this paper
• Structural diversity of G protein-coupled receptors and significance for drug discovery

  2008cited by this paper
• A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling

  2007cited by this paper
• Prediction of Mode of Death in Heart Failure: The Seattle Heart Failure Model

  2007cited by this paper
• (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through β2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling

  2007cited by this paper
• G protein coupled receptor structure and activation.

  2007cited by this paper
• Arg389Gly-&bgr;1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol

  2007cited by this paper
• Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart.

  2006cited by this paper
• Multiple signalling pathways involved in β2‐adrenoceptor‐mediated glucose uptake in rat skeletal muscle cells

  2006cited by this paper
• The selectivity of β‐adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors

  2005cited by this paper
• Differential cardioprotective/cardiotoxic effects mediated by beta-adrenergic receptor subtypes.

  2005cited by this paper
• Ischemic Neoangiogenesis Enhanced by &bgr;2-Adrenergic Receptor Overexpression: A Novel Role for the Endothelial Adrenergic System

  2005cited by this paper
• Regulation of cardiac contractile function by troponin I phosphorylation.

  2005cited by this paper
• Fundamental considerations of β-adrenoceptor subtypes in human heart failure

  2005cited by this paper
• Cellular basis of triggered arrhythmias in heart failure.

  2004cited by this paper
• The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints.

  2003cited by this paper
• Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells

  2003cited by this paper
• β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

  2003cited by this paper
• Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial.

  2003cited by this paper
• Cardiac excitation–contraction coupling

  2002cited by this paper
• Characterization of the β‐adrenoceptor subtype involved in mediation of glucose transport in L6 cells

  2002cited by this paper
• Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.

  2001cited by this paper
• Sarcoplasmic reticulum Ca(2+) release causes myocyte depolarization. Underlying mechanism and threshold for triggered action potentials.

  2000cited by this paper
• The β2-Adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through Gi-Dependent coupling to phosphatidylinositol 3'-kinase

  2000cited by this paper
• Both &bgr;2- and &bgr;1-Adrenergic Receptors Mediate Hastened Relaxation and Phosphorylation of Phospholamban and Troponin I in Ventricular Myocardium of Fallot Infants, Consistent With Selective Coupling of &bgr;2-Adrenergic Receptors to Gs-Protein

  2000cited by this paper
• The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

  1998cited by this paper
• cAMP‐dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation

  1997cited by this paper
• Adrenergic nervous system in heart failure.

  1997cited by this paper
• Functional beta3-adrenoceptor in the human heart.

  1996cited by this paper
• Phospholamban: a prominent regulator of myocardial contractility.

  1996cited by this paper
• Regional epinephrine kinetics in human heart failure: evidence for extra-adrenal, nonneural release.

  1995cited by this paper
• Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes.

  1995cited by this paper
• Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

  1994cited by this paper
• Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

  1993cited by this paper
• Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger.

  1992cited by this paper
• Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group.

  1991cited by this paper
• Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias.

  1991cited by this paper
• Intracoronary Injections of Salbutamol Demonstrate the Presence of Functional ft-Adrenoceptors in the Human Heart

  1989cited by this paper
• Characterization and autoradiographic localization of β‐adrenoceptor subtypes in human cardiac tissues

  1987cited by this paper
• A family of receptors coupled to guanine nucleotide regulatory proteins.

  1987cited by this paper
• Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

  1986cited by this paper
• The affinity and efficacy of naturally occurring catecholamines at β‐adrenoceptor subtypes

  1985cited by this paper
• Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure.

  1984cited by this paper
• Effect of chronic beta-adrenergic receptor blockade in congestive cardiomyopathy.

  1975cited by this paper
• Activation of (cid:98) 2 -Adrenergic Receptors Hastens Relaxation and Mediates Phosphorylation of Phospholamban, Troponin I, and C-Protein in Ventricular Myocardium From Patients With Terminal Heart Failure

  year unknowncited by this paper

• No citing papers are available for this paper.