Effect-directed analysis (EDA) in aquatic ecotoxicology: state of the art and future challenges

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Environmental science and pollution research international

• Publication date

  2009-08-25

• Fields of study

  Medicine, Engineering, Environmental Science

• Identifiers
  DOI 10.1007/s11356-009-0229-yPMID 19705177
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The endocrine disrupting potential of sediments from the Upper Danube River (Germany) as revealed by in vitro bioassays and chemical analysis

  2011cited by this paper
• Über die Notwendigkeit der wirkungsorientierten Analytik in einer umfassenden Wasserforschung

  2009influential reference
• Evaluation of phase II toxicity identification evaluation methods for freshwater whole sediment and interstitial water.

  2009influential reference
• Integral assessment of estrogenic potentials in sediment-associated samples

  2009cited by this paper
• Effektorientierte Untersuchungen zur Algentoxizität fraktionierter Porenwässer und Eluate aus Elbesedimenten

  2009cited by this paper
• Masking effect of anti-androgens on androgenic activity in European river sediment unveiled by effect-directed analysis

  2009influential reference
• In search for the ecological and toxicological relevance of sediment re-mobilisation and transport during flood events

  2009cited by this paper
• A fuzzy logic-classification of sediments based on data from in vitro biotests

  2009cited by this paper
• Endocrine disruptors in bottled mineral water: total estrogenic burden and migration from plastic bottles

  2009cited by this paper
• Toward an Integrated Assessment of the Ecological and Chemical Status of European River Basins

  2009cited by this paper
• Das Potenzial genetisch modifizierter und gentechnisch konstruierter Organismen in der wirkungsbezogenen Analytik

  2009cited by this paper
• Eine Weight-of-Evidence-Studie zur Bewertung der Sedimentbelastung und des Fischrückgangs in der Oberen Donau

  2009cited by this paper
• Identifizierung toxischer Verbindungen in Sedimenten: Ansätze zur Integration von Wirkung und Bioverfügbarkeit

  2009cited by this paper
• Der Fischrückgang in der oberen Donau

  2009cited by this paper
• Partitioning-based dosing: an approach to include bioavailability in the effect-directed analysis of contaminated sediment samples.

  2009cited by this paper
• An indispensable asset at risk: merits and needs of chemicals-related environmental sciences

  2009cited by this paper
• A critical analysis of the biological impacts of plasticizers on wildlife

  2009cited by this paper
• Changes in toxicity and Ah receptor agonist activity of suspended particulate matter during flood events at the rivers Neckar and Rhine — a mass balance approach using in vitro methods and chemical analysis

  2008cited by this paper
• Automated fractionation procedure for polycyclic aromatic compounds in sediment extracts on three coupled normal-phase high-performance liquid chromatography columns.

  2008cited by this paper
• Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay

  2008cited by this paper
• How to confirm identified toxicants in effect-directed analysis

  2008influential reference
• Activities and identification of aryl hydrocarbon receptor agonists in sediments from the Danube river

  2008cited by this paper
• Measurement of genotoxicity in wastewater samples with the in vitro micronucleus test: results of a round-robin study in the context of standardisation according to ISO.

  2008cited by this paper
• The use of MS classifiers and structure generation to assist in the identification of unknowns in effect-directed analysis.

  2008cited by this paper
• Novel trends in endocrine disruptor testing: the H295R Steroidogenesis Assay for identification of inducers and inhibitors of hormone production

  2008cited by this paper
• Integral assessment of estrogenic potentials of sediment-associated samples

  2008cited by this paper
• Polychlorinated naphthalenes and other dioxin‐like compounds in Elbe River sediments

  2008cited by this paper
• The zebrafish embryo model in environmental risk assessment—applications beyond acute toxicity testing

  2008cited by this paper
• Contamination history of suspended river sediments accumulated in oxbow lakes over the last 25 years

  2008cited by this paper
• Adaptive management principles and sediment management

  2008cited by this paper
• Hazard identification of contaminated sites—ranking potential toxicity of organic sediment extracts in crustacean and fish

  2008cited by this paper
• Trends and challenges in sediment research 2008: the role of sediments in river basin management

  2008cited by this paper
• Relative differences in aryl hydrocarbon receptor‐mediated response for 18 polybrominated and mixed halogenated dibenzo‐P‐dioxins and ‐furans in cell lines from four different species

  2007cited by this paper
• Fractionation and Determination of Ah Receptor (AhR) Agonists in Organic Waste After Anaerobic Biodegradation and in Batch Experiments with PCB and decaBDE (8 pp)

  2007cited by this paper
• Perfluorooctane Sulfonate Increases the Genotoxicity of Cyclophosphamide in the Micronucleus Assay with V79 Cells: Further Proof of Alterations in Cell Membrane Properties Caused by PFOS (3 pp)

  2007cited by this paper
• Biological Activity in a Heavily Organohalogen-Contaminated River Sediment (8 pp)

  2007cited by this paper
• Large volume TENAX® extraction of the bioaccessible fraction of sediment-associated organic compounds for a subsequent effect-directed analysis

  2007cited by this paper
• Effect-Directed Analysis of Key Toxicants in European River Basins. A Review (9 pp)

  2007cited by this paper
• Reed beds receiving industrial sludge containing nitroaromatic compounds

  2007cited by this paper
• Redistribution of organic pollutants in river sediments and alluvial soils related to major floods

  2007cited by this paper
• Fractionation of technical p-nonylphenol with preparative capillary gas chromatography.

  2007cited by this paper
• Differentiation between bioavailable and total hazard potential of sediment-induced DNA fragmentation as measured by the comet assay with Zebrafish embryos

  2007cited by this paper
• Sediment Properties for Assessing the Erosion Risk of Contaminated Riverine Sites. An approach to evaluate sediment properties and their covariance patterns over depth in relation to erosion resistance. First investigations in natural sediments (11 pp)

  2007cited by this paper
• The German Environmental Specimen Bank

  2007cited by this paper
• Sediment Management: An essential element of River Basin Management Plans

  2007cited by this paper
• The OECD Validation Program of the H295R Steroidogenesis Assay for the Identification of In Vitro Inhibitors and Inducers of Testosterone and Estradiol Production. Phase 2: Inter-Laboratory Pre-Validation Studies (8 pp)

  2007cited by this paper
• Should the Sediment Quality Triad Become a Tetrad, a Pentad, or Possibly even a Hexad?

  2006cited by this paper
• Ecotoxicological Assessment of Sediment, Suspended Matter and Water Samples in the Upper Danube River. A pilot study in search for the causes for the decline of fish catches (12 pp)

  2006cited by this paper
• Ethoxyresorufin-O-deethylase (EROD) Activity in Dab (Limanda limanda) as Biomarker for Marine Monitoring (6 pp)

  2005influential reference
• Effect‐directed analysis of mutagens and ethoxyresorufin‐O‐deethylase inducers in aquatic sediments

  2005cited by this paper
• Endocrine Disruption of Water and Sediment Extracts in a Non-Radioactive Dot Blot/RNAse Protection-Assay Using Isolated Hepatocytes of Rainbow Trout (14 pp).Deficiencies between bioanalytical effectiveness and chemically determined concentrations and how to explain them

  2005cited by this paper
• Bioassay-directed Fractionation of Organic Extracts of Marine Surface Sediments from the North and Baltic Sea - Part II: Results of the biotest battery and development of a biotest index (8 pp)

  2005influential reference
• Bioassay-directed Fractionation of Organic Extracts of Marine Surface Sediments from the North and Baltic Sea - Part I: Determination and identification of organic pollutants (15 pp)

  2005cited by this paper
• MODELKEY. Models for assessing and forecasting the impact of environmental key pollutants on freshwater and marine ecosystems and biodiversity (5 pp)

  2005influential reference
• Comparative genotoxicity testing of rhine river sediment extracts using the comet assay with permanent fish cell lines (rtg-2 and rtl-w1) and the ames test*

  2004cited by this paper
• Combined biological and chemical assessment of estrogenic activities in wastewater treatment plant effluents

  2004cited by this paper
• The mutagenic hazards of aquatic sediments: a review.

  2004cited by this paper
• Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures?

  2003influential reference
• Sequential fractionation procedure for the identification of potentially cytochrome P4501A-inducing compounds.

  2003cited by this paper
• Peer Reviewed: Perfluorochemical Surfactants in the Environment

  2002cited by this paper
• Biological and Chemical Determination of Dioxin-like Compounds in Sediments by Means of a Sediment Triad Approach in the Catchment Area of the River Neckar

  2002cited by this paper
• Perfluorochemical surfactants in the environment.

  2002cited by this paper
• Cell bioassays for detection of aryl hydrocarbon (AhR) and estrogen receptor (ER) mediated activity in environmental samples.

  2002influential reference
• Estrogenic activity measured in a sewage treatment works treating industrial inputs containing high concentrations of alkylphenolic compounds—A case study

  2002cited by this paper
• Identification and quantification of estrogen receptor agonists in wastewater effluents.

  2001influential reference
• Input/output balance of estrogenic active compounds in a major municipal sewage plant in Germany.

  2000influential reference
• Cell bioassays for detection of aryl hydrocarbon (AhR) and estrogen receptor (ER) mediated activity in environmental samples

  2000cited by this paper
• Health Effects of Endocrine-Disrupting Chemicals on Wildlife, with Special Reference to the European Situation

  2000cited by this paper
• Characterization and distribution of trace organic contaminants in sediment from Masan Bay, Korea. 2: In vitro gene expression assays

  1999influential reference
• Characterization and Distribution of Trace Organic Contaminants in Sediment from Masan Bay , Korea

  1999cited by this paper
• Characterization and Distribution of Trace Organic Contaminants in Sediment from Masan Bay, Korea. 1. Instrumental Analysis

  1999cited by this paper
• Alkylphenols, polycyclic aromatic hydrocarbons, and organochlorines in sediment from Lake Shihwa, Korea: Instrumental and bioanalytical characterization

  1999cited by this paper
• Levels of dioxin-like compounds in sewage sludge determined with a bioassay based on EROD induction in chicken embryo liver cultures.

  1999cited by this paper
• Identification of Estrogenic Chemicals in STW Effluent. 2. In Vivo Responses in Trout and Roach

  1998cited by this paper
• Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife.

  1998cited by this paper
• Genotoxicity assessment of suspended particulate matter in the Elbe river: comparison of Salmonella microsome test, arabinose resistance test, and umu-test.

  1997cited by this paper
• Mutagenic effect of extracts from particulate matter collected with sediment traps in the archipelago of stockholm and the open Northern Baltic

  1994cited by this paper
• Bioassay-Directed Chemical Analysis of Genotoxic Components in Coastal Sediments

  1992cited by this paper
• Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).

  1990cited by this paper
• Bioassay-directed chemical analysis in environmental research.

  1986cited by this paper
• Combined bioassay-chemical fractionation scheme for the determination and ranking of toxic chemicals in sediments

  1983cited by this paper

• Assessing the impact of environmental laws and technological advancements on carbon dioxide mitigation in China’s mining industry

  2025cites this paper
• Priorities to inform research on tire particles and their chemical leachates: A collective perspective.

  2024cites this paper
• Exploitation of environmental DNA (eDNA) for ecotoxicological research: A critical review on eDNA metabarcoding in assessing marine pollution.

  2024cites this paper
• A protocol for lixiviation of micronized plastics for aquatic toxicity testing.

  2023cites this paper
• A bioanalytical approach for assessing the effects of soil extracts from solid waste dumpsite in Calabar (Nigeria) on lipid and estrogenic signaling of fish Poeciliopsis lucida hepatocellular carcinoma-1 cells in vitro and in vivo African catfish (Clarias gariepinus)

  2023cites this paper
• Integrated Exposure and Algal Ecotoxicological Assessments of Effluents from Secondary and Advanced‐Tertiary Wastewater‐Treatment Plants

  2022cites this paper
• The zebrafish (Danio rerio) embryo-larval contact assay combined with biochemical biomarkers and swimming performance in sewage sludge and hydrochar hazard assessment.

  2022cites this paper
• Effect-based evaluation of ozone treatment for removal of micropollutants and their transformation products in waste water

  2021cites this paper
• (Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future.

  2021cites this paper
• The challenge of micropollutants in surface water of the Yangtze River.

  2021cites this paper
• Seasonal performance assessment of four riverbank filtration sites by combined non-target and effect-directed analysis.

  2020cites this paper
• Identification of acetylcholinesterase inhibitors in water by combining two-dimensional thin-layer chromatography and high-resolution mass spectrometry.

  2020cites this paper
• Acute ecotoxicity and genotoxicity assessment of two wastewater treatment units

  2020cites this paper
• Toxicity assessment of Lemna solid waste dumpsite (Calabar, Nigeria) using different extraction methods and toxicological responses of PLHC-1 cells.

  2020cites this paper
• Whole-Sediment Toxicity Bioassay to Determine Bioavailability and Effects of Aquatic Contaminants Using Zebrafish Embryos

  2020cites this paper
• Development of a separation framework for effects-based targeted and non-targeted toxicological screening of water and wastewater.

  2019cites this paper
• Effect-based and chemical analyses of agonistic and antagonistic endocrine disruptors in multiple matrices of eutrophic freshwaters.

  2019cites this paper
• Integrated zebrafish-based tests as an investigation strategy for water quality assessment.

  2019cites this paper
• Development of a Chemical Separation Framework for Effects-Directed Analysis of Water and Wastewater

  2018cites this paper
• An ecotoxicological view on neurotoxicity assessment

  2018cites this paper
• Looking back - Looking forward: A novel multi-time slice weight-of-evidence approach for defining reference conditions to assess the impact of human activities on lake systems.

  2018cites this paper
• Biochemical responses of Solea senegalensis after continuous flow exposure to urban effluents.

  2018cites this paper
• Integrated Framework for Identifying Toxic Transformation Products in Complex Environmental Mixtures.

  2017cites this paper
• Effect-Directed Analysis of Toxicants in Sediment with Combined Passive Dosing and in Vivo Toxicity Testing.

  2017cites this paper
• Screening and Examining “Exotic” Chemicals in Swift Current Creek, SK, Canada

  2017influential citation
• Water, 1. Properties, Analysis, and Hydrological Cycle

  2016cites this paper
• Effect-directed analysis: Current status and future challenges

  2016cites this paper
• Are styrene oligomers in coastal sediments of an industrial area aryl hydrocarbon-receptor agonists?

  2016cites this paper
• Bacterial toxicity assessment of drinking water treatment residue (DWTR) and lake sediment amended with DWTR.

  2016cites this paper
• Are sediments a risk? An ecotoxicological assessment of sediments from a quarry pond of the Upper Rhine River

  2016cites this paper
• Effect-Directed Analysis of Aryl Hydrocarbon Receptor Agonists in Sediments from the Three Gorges Reservoir, China.

  2016cites this paper
• TLC-Direct Bioautography as a High Throughput Method for Detection of Antimicrobials in Plants

  2015cites this paper
• Endocrine activity in the aquatic environment - Establishment of a bioassay battery to detect endocrine disruptive substances in various sample matrices

  2015cites this paper
• Effects-Directed Analysis of Dissolved Organic Compounds in Oil Sands Process-Affected Water.

  2015cites this paper
• Assessment of biomarkers for contaminants of emerging concern on aquatic organisms downstream of a municipal wastewater discharge.

  2015cites this paper
• Yangtze Three Gorges Reservoir, China: A holistic assessment of organic pollution, mutagenic effects of sediments and genotoxic impacts on fish.

  2015cites this paper
• DNA damage caused by organic extracts of contaminated sediment, crude, and weathered oil and their fractions recovered up to 5 years after the 2007 Hebei Spirit oil spill off Korea.

  2015cites this paper
• Investigation of potential endocrine disrupting effects of mosquito larvicidal Bacillus thuringiensis israelensis (Bti) formulations.

  2015cites this paper
• Chapter ( summary report ) on : Large volume sampling and effect-based screening

  2015cites this paper
• Evaluation of the hazard potentials of river suspended particulate matter and floodplain soils in the Rhine basin using chemical analysis and in vitro bioassays

  2015cites this paper
• Is the toxicity of pesticide mixtures on river biofilm accounted for solely by the major compounds identified?

  2015cites this paper
• Anthropogenic Trace Compounds (ATCs) in aquatic habitats - research needs on sources, fate, detection and toxicity to ensure timely elimination strategies and risk management.

  2015cites this paper
• Assessment of the Mutagenicity of Sediments from Yangtze River Estuary Using Salmonella Typhimurium/Microsome Assay

  2015cites this paper
• Linking Ah receptor mediated effects of sediments and impacts on fish to key pollutants in the Yangtze Three Gorges Reservoir, China - A comprehensive perspective.

  2015cites this paper
• The toxicity of sediments from Taihu Lake evaluated by several in vitro bioassays

  2015cites this paper
• Characterization of aryl hydrocarbon receptor agonists in the Norwegian environment

  2015cites this paper
• The value of zebrafish as an integrative model in effect-directed analysis - a review

  2015influential citation
• Challenges in effect-directed analysis with a focus on biological samples

  2015cites this paper
• Effects-Directed Biological Detection

  2015cites this paper
• Environmental risk assessment of combined effects in aquatic ecotoxicology: a discussion paper.

  2014cites this paper
• Mutagenicity, dioxin-like activity and bioaccumulation of alkylated picene and chrysene derivatives in a German lignite.

  2014cites this paper
• The impact of municipal wastewater effluent on field‐deployed freshwater mussels in the Grand River (Ontario, Canada)

  2014cites this paper
• Toxicity and Risk of Transformation Products of Emerging Contaminants for Aquatic Organisms: Pharmaceutical Case Studies

  2014cites this paper
• Assessing Advanced Oxidation Transformation Products

  2014cites this paper
• Effects of multiwalled carbon nanotubes and triclocarban on several eukaryotic cell lines: elucidating cytotoxicity, endocrine disruption, and reactive oxygen species generation

  2014cites this paper
• At the end of the life cycle of carbon nanotubes : an ecotoxicological point of view

  2014cites this paper
• 12 TH IHPA FORUM AND SELECTED STUDIES ON POPS Evaluation of the hazard potentials of river suspended particulate matter and floodplain soils in the Rhine basin using chemical analysis and in vitro bioassays

  2014cites this paper
• Integrated toxicity evaluation of a pulp deposit using organisms of different trophic levels

  2013cites this paper
• In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents.

  2013cites this paper
• The dioRAMA project: assessment of dioxin-like activity in sediments and fish (Rutilus rutilus) in support of the ecotoxicological characterization of sediments

  2013cites this paper
• Solution by dilution?—A review on the pollution status of the Yangtze River

  2013cites this paper
• Contribution of Priority PAHs and POPs to Ah Receptor-Mediated Activities in Sediment Samples from the River Elbe Estuary, Germany

  2013cites this paper
• Cell Lines in Aquatic Toxicology

  2013cites this paper
• Biotests for hazard assessment of biofuel fermentation

  2012cites this paper
• Effect directed analysis and mixture effects of estrogenic compounds in a sediment of the river Elbe

  2012cites this paper
• Endocrine disrupting, mutagenic, and teratogenic effects of upper Danube River sediments using effect‐directed analysis

  2012cites this paper
• Ecotoxicological assessment and evaluation of a pine bark biosorbent treatment of five landfill leachates.

  2012cites this paper
• The interaction of chemicals isolated from municipal wastewater effluent with rainbow trout (Oncorhynchus mykiss) thyroid hormone receptors

  2012cites this paper
• Perspectives from the French workshop on the development and validation of biomarkers and bioassays for the monitoring of aquatic environments

  2012cites this paper
• Toxicology of water.

  2012cites this paper
• Influence of different flow conditions on the occurrence and behavior of potentially hazardous organic xenobiotics in the influent and effluent of a municipal sewage treatment plant in Germany: an effect-directed approach

  2012cites this paper
• Analytical methods relevant to the European Commission's 2012 proposal on Priority Substances under the Water Framework Directive

  2012cites this paper
• Sediment contact test with Potamopyrgus antipodarum in effect-directed analyses—challenges and opportunities

  2011cites this paper
• The versatile, changing, and advancing roles of fish in sediment toxicity assessment—a review

  2011cites this paper
• Anthropogenic pollutants affect ecosystem services of freshwater sediments: the need for a “triad plus x” approach

  2011cites this paper
• Combining polar organic chemical integrative samplers (POCIS) with toxicity testing to evaluate pesticide mixture effects on natural phototrophic biofilms.

  2011cites this paper
• Recent advances in environmental analysis.

  2011cites this paper
• Endocrine disruptor screening: regulatory perspectives and needs

  2011cites this paper
• Effect directed analysis of riverine sediments--the usefulness of Potamopyrgus antipodarum for in vivo effect confirmation of endocrine disruption.

  2011cites this paper
• Ecological Relevance of Key Toxicants in Aquatic Systems

  2011cites this paper
• New challenges in environmental analytical chemistry: Identification of toxic compounds in complex mixtures

  2011cites this paper
• Simultaneous Screening and Chemical Characterization of Bioactive Compounds Using LC-MS-Based Technologies (Affinity Chromatography)

  2011cites this paper
• Behavioural ecotoxicology, an “early warning” signal to assess environmental quality

  2010influential citation
• Toxizität und Risk Assessment fluvialer Sedimente und Schwebstoffe: Eine kurze Übersicht bisheriger und neuerer Entwicklungen

  2010cites this paper
• Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis.

  2010cites this paper
• DanTox—a novel joint research project using zebrafish (Danio rerio) to identify specific toxicity and molecular modes of action of sediment-bound pollutants

  2010cites this paper
• Toxicity and risk assessment of fluvial sediments and suspended matter: a short overview of past and recent developments in sediment toxicity assessment

  2010cites this paper
• Recent advances in environmental analysis.

  2009cites this paper
• Journal Pre-proof The zebrafish ( Danio

  year unknowncites this paper