Newly synthesized G protein of vesicular stomatitis virus is not transported to the cell surface during mitosis

Indirect immunofluorescence, immunoelectron microscopy, and digestion by protease were used to study intracellular transport of the G protein of vesicular stomatitis virus in mitotic and interphase cells. Quantitation showed that the appearance of G protein on the surface of mitotic cells was inhibited at least 10-fold when compared with that on interphase cells, even though similar amounts of viral protein were being synthesized. This dramatic inhibition, taken together with the simultaneous inhibition of endocytosis (Berlin, R. D., and J. M. Oliver, 1980, J. Cell Biol. 85: 660-671), points to a general cessation of membrane traffic in the mitotic cell.

• Publication year

  1983

• Venue

  Journal of Cell Biology

• Publication date

  1983-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/JCB.97.5.1623PMID 6355124PMCID 2112686
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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