TGF&bgr;RIIb Mutations Trigger Aortic Aneurysm Pathogenesis by Altering Transforming Growth Factor &bgr;2 Signal Transduction

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Circulation: Cardiovascular Genetics

• Publication date

  2012-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/CIRCGENETICS.112.964064PMID 23099432PMCID PMC3547593
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

  2012cited by this paper
• Normal limits in relation to age, body size and gender of two-dimensional echocardiographic aortic root dimensions in persons ≥15 years of age.

  2012cited by this paper
• Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

  2011cited by this paper
• Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

  2011cited by this paper
• Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

  2011cited by this paper
• The revised Ghent nosology for the Marfan syndrome

  2010cited by this paper
• TWO-DIMENSIONAL ECHOCARDIOGRAPHIC AORTIC ROOT DIMENSIONS IN ADOLESCENTS AND ADULTS: NORMAL LIMITS IN RELATION TO AGE, BODY SIZE AND GENDER

  2010cited by this paper
• TGF-β signaling in aortic aneurysm: another round of controversy.

  2010cited by this paper
• Genetic analysis of young adult patients with aortic disease not fulfilling the diagnostic criteria for Marfan syndrome.

  2010cited by this paper
• Mutations in myosin light chain kinase cause familial aortic dissections.

  2010cited by this paper
• Abstract 1654: Prevalence and Correlates of Aortic Root Dilatation in Normotensive and Hypertensive Adults: The Family Blood Pressure Program

  2009cited by this paper
• Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.

  2009cited by this paper
• Regulating the stability of TGFβ receptors and Smads

  2009cited by this paper
• Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations

  2009cited by this paper
• Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis.

  2009cited by this paper
• Syndromic and non‐syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

  2009cited by this paper
• Transforming Growth Factor-β Signaling in Thoracic Aortic Aneurysm Development: A Paradox in Pathogenesis

  2008cited by this paper
• Identification of 23 TGFBR2 and 6 TGFBR1 gene mutations and genotype‐phenotype investigations in 457 patients with Marfan syndrome type I and II, Loeys‐Dietz syndrome and related disorders

  2008cited by this paper
• Mutations in smooth muscle α-actin (ACTA2) lead to thoracic aortic aneurysms and dissections

  2007cited by this paper
• Familial thoracic aortic aneurysms and dissections--incidence, modes of inheritance, and phenotypic patterns.

  2007cited by this paper
• Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus

  2006cited by this paper
• TGFBR1 and TGFBR2 mutations in patients with features of Marfan syndrome and Loeys‐Dietz syndrome

  2006cited by this paper
• Constitutive homo- and hetero-oligomerization of TbetaRII-B, an alternatively spliced variant of the mouse TGF-beta type II receptor.

  2006cited by this paper
• Constitutive homo- and hetero-oligomerization of TβRII-B, an alternatively spliced variant of the mouse TGF-β type II receptor

  2006cited by this paper
• Heterozygous TGFBR2 mutations in Marfan syndrome

  2005cited by this paper
• A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2

  2005cited by this paper
• Mutations in Transforming Growth Factor-&bgr; Receptor Type II Cause Familial Thoracic Aortic Aneurysms and Dissections

  2005cited by this paper
• Heterozygous TGFBR2 mutations in Marfan syndrome

  2004cited by this paper
• In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2.

  2004cited by this paper
• In the Absence of Type III Receptor, the Transforming Growth Factor (TGF)-β Type II-B Receptor Requires the Type I Receptor to Bind TGF-β2*

  2004cited by this paper
• Mapping a Locus for Familial Thoracic Aortic Aneurysms and Dissections (TAAD2) to 3p24–25

  2003cited by this paper
• Genetic Influences on Aortic Root Size in American Indians: The Strong Heart Study

  2002cited by this paper
• Aortic Root Dilatation at Sinuses of Valsalva and Aortic Regurgitation in Hypertensive and Normotensive Subjects: The Hypertension Genetic Epidemiology Network Study

  2001cited by this paper
• Type III TGF‐β receptor‐independent signalling of TGF‐β2 via TβRII‐B, an alternatively spliced TGF‐β type II receptor

  2001cited by this paper
• Identification of a Chromosome 11q23.2-q24 Locus for Familial Aortic Aneurysm Disease, a Genetically Heterogeneous Disorder

  2001cited by this paper
• Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor.

  2001cited by this paper
• Familial Thoracic Aortic Aneurysms and Dissections: Genetic Heterogeneity With a Major Locus Mapping to 5q13-14

  2001cited by this paper
• Recombination and Mutagenesis by Overlap Extension PCR

  2000cited by this paper
• Familial patterns of thoracic aortic aneurysms.

  1999influential reference
• Extracellular Domain of the Transforming Growth Factor-β Receptor Negatively Regulates Ligand-independent Receptor Activation*

  1999cited by this paper
• TGF-beta signal transduction.

  1998cited by this paper
• A human transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain.

  1996cited by this paper
• Phosphorylation-dependent Interaction of the Cytoplasmic Domains of the Type I and Type II Transforming Growth Factor- Receptors (*)

  1995cited by this paper
• Characterization of type I receptors for transforming growth factor-beta and activin.

  1994cited by this paper
• Betaglycan presents ligand to the TGFβ signaling receptor

  1993cited by this paper
• Betaglycan presents ligand to the TGF beta signaling receptor.

  1993cited by this paper

• Perioperative risk factors predict one-year mortality in patients with acute type-A aortic dissection

  2020cites this paper
• Long Noncoding RNA Hypoxia-Inducible Factor-1 Alpha-Antisense RNA 1 Regulates Vascular Smooth Muscle Cells to Promote the Development of Thoracic Aortic Aneurysm by Modulating Apoptotic Protease-Activating Factor 1 and Targeting let-7g.

  2020cites this paper
• A new Variant in the MYH11 gene in a Familial case of Thoracic Aortic Aneurysm.

  2020cites this paper
• European reference network for rare vascular diseases (VASCERN) consensus statement for the screening and management of patients with pathogenic ACTA2 variants

  2019cites this paper
• Angiotensin, transforming growth factor β and aortic dilatation in Marfan syndrome: Of mice and humans☆

  2018cites this paper
• Age-related presentation of acute type A aortic dissection

  2018cites this paper
• Systematic Review of Studies That Have Evaluated Screening Tests in Relatives of Patients Affected by Nonsyndromic Thoracic Aortic Disease

  2018influential citation
• Molecular targets in aortic aneurysm for establishing novel management paradigms.

  2017cites this paper
• Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish

  2016cites this paper
• Alpha-actin-2 mutations in Chinese patients with a non-syndromatic thoracic aortic aneurysm

  2016cites this paper
• Nifedipine attenuation of abdominal aortic aneurysm in hypertensive and non-hypertensive mice: Mechanisms and implications.

  2015cites this paper
• Vascular Smooth Muscle Cell Phenotypic Changes in Patients With Marfan Syndrome

  2015cites this paper
• Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels

  2015cites this paper
• Association of the polymorphisms of MMP-9 and TIMP-3 genes with thoracic aortic dissection in Chinese Han population

  2014cites this paper
• Role of TGF-β Pathway Polymorphisms in Sporadic Thoracic Aortic Aneurysm: rs900 TGF-β2 Is a Marker of Differential Gender Susceptibility

  2014cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease Respiratory Dysfunction in Congenital Heart Disease Patients With Heterotaxy Circulation Editors’ Picks Most Read in Cardiovascular Genetics

  2013cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease Respiratory Dysfunction in Congenital Heart Disease Patients With Heterotaxy Circulation Editors’ Picks Most Read in Cardiovascular Genetics

  2013cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage- Gated Na+ Channel in Cardiac Disease

  2013cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease Respiratory Dysfunction in Congenital Heart Disease Patients With Heterotaxy Circulation Editors’ Picks Most Read in Cardiovascular Genetics

  2013cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease Respiratory Dysfunction in Congenital Heart Disease Patients With Heterotaxy Circulation Editors’ Picks Most Read in Cardiovascular Genetics

  2013cites this paper
• Pathophysiology of AAA: heredity vs environment.

  2013cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage- Gated Na+ Channel in Cardiac Disease

  2013cites this paper
• Ca2+/Calmodulin-Dependent Protein Kinase II–Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease Respiratory Dysfunction in Congenital Heart Disease Patients With Heterotaxy Circulation Editors’ Picks Most Read in Cardiovascular Genetics

  2013cites this paper