Effects of Aging on mRNA Profiles for Drug-Metabolizing Enzymes and Transporters in Livers of Male and Female Mice

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Drug Metabolism And Disposition

• Publication date

  2012-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/dmd.111.044461PMID 22446518PMCID PMC3362785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Steroid regulation of drug-metabolizing cytochromes P450.

  2011cited by this paper
• Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

  2010cited by this paper
• Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

  2010cited by this paper
• Mechanism of Gender-Divergent UDP-Glucuronosyltransferase mRNA Expression in Mouse Liver and Kidney

  2009cited by this paper
• Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity.

  2009cited by this paper
• Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver

  2009cited by this paper
• Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

  2008cited by this paper
• Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.

  2008cited by this paper
• Xenobiotic transporters: ascribing function from gene knockout and mutation studies.

  2008cited by this paper
• Drug therapy in elderly.

  2008cited by this paper
• Hepatic Transcript Levels for Genes Coding for Enzymes Associated with Xenobiotic Metabolism are Altered with Age

  2007influential reference
• Constitutive mRNA expression of various glutathione S-transferase isoforms in different tissues of mice.

  2007cited by this paper
• Hormonal regulation of renal multidrug resistance-associated proteins 3 and 4 (Mrp3 and Mrp4) in mice.

  2006cited by this paper
• Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression

  2006cited by this paper
• Growth hormone regulation of sex-dependent liver gene expression.

  2006cited by this paper
• Tissue distribution and ontogeny of sulfotransferase enzymes in mice.

  2006cited by this paper
• TISSUE DISTRIBUTION AND ONTOGENY OF MOUSE ORGANIC ANION TRANSPORTING POLYPEPTIDES (OATPS)

  2005cited by this paper
• Profile of Territrem Metabolism and Cytochrome P-450 3A Expression in Liver Microsomes from Wistar Rats of Both Genders as a Function of Age

  2005cited by this paper
• Mammalian carboxylesterases: from drug targets to protein therapeutics.

  2005cited by this paper
• Regulation of hepatic transporters by xenobiotic receptors.

  2005cited by this paper
• Human glutathione transferase A3-3 active as steroid double-bond isomerase.

  2005cited by this paper
• Endogenous sex hormones in relation to age, sex, lifestyle factors, and chronic diseases in a general population: the Tromsø Study.

  2004cited by this paper
• Tissue distribution and hormonal regulation of the breast cancer resistance protein (Bcrp/Abcg2) in rats and mice.

  2004cited by this paper
• Age-related changes in the protein and mRNA levels of CYP2E1 and CYP3A isoforms as well as in their hepatic activities in Wistar rats. What role for oxidative stress?

  2004cited by this paper
• Age-related changes in the protein and mRNA levels of CYP 2 E 1 and CYP 3 A isoforms as well as in their hepatic activities in Wistar rats . What role for oxidative stress ?

  2004cited by this paper
• Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR).

  2004cited by this paper
• Age-Related Differences in CYP3A Expression and Activity in the Rat Liver, Intestine, and Kidney

  2004cited by this paper
• Pharmacokinetics in older persons.

  2004cited by this paper
• Human Glutathione Transferase A3-3, a Highly Efficient Catalyst of Double-bond Isomerization in the Biosynthetic Pathway of Steroid Hormones*

  2001cited by this paper
• Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile.

  1999influential reference
• Molecular cloning and expression of an amine sulfotransferase cDNA: a new gene family of cytosolic sulfotransferases in mammals.

  1998cited by this paper
• Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer.

  1998cited by this paper
• Effect of aging on mixed-function oxidation and conjugation by isolated perfused rat livers.

  1997cited by this paper
• Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases.

  1996cited by this paper
• Bacterial expression and characterization of a cDNA for human liver estrogen sulfotransferase.

  1995cited by this paper
• Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver.

  1993influential reference
• Carcinogenicity of p-chloroaniline in rats and mice.

  1991cited by this paper
• Pharmacokinetic basis of age-related changes in sensitivity to toxicants.

  1991cited by this paper
• Effects of human growth hormone in men over 60 years old.

  1990cited by this paper

• Carrier free oral Co-delivery of atorvastatin via baicalein-copper-network for atherosclerosis therapy through senescence reversal and multi-mechanistic synergy

  2026cites this paper
• Effect of age and sex on the urinary elimination of a single dose of mixed flavonoids: results from a single-arm intervention in healthy United Kingdom adults

  2025cites this paper
• Liver aging: underlying mechanisms and therapeutic strategies.

  2025cites this paper
• Sex differences in hepatic enzymes and transporters involved in pharmacokinetics

  2025cites this paper
• Aging Reduces ATP-Binding Cassette Transporter Expression in Brain Microvessels of Mice

  2025cites this paper
• Sex differences in aristolochic acid I-induced nephrotoxicity in mice and the effect of estradiol.

  2025cites this paper
• Persistent Post COVID-19 Endothelial Dysfunction and Oxidative Stress in Women

  2024cites this paper
• More than a number: Incorporating the aged phenotype to improve in vitro and in vivo modeling of neurodegenerative disease.

  2024cites this paper
• Sex Differences in the Absorption, Disposition, Metabolism, and Excretion of Grape Seed Proanthocyanidins in Prepubescent Rats.

  2024cites this paper
• Sex dimorphism and tissue specificity of gene expression changes in aging mice

  2024cites this paper
• Chronic polypharmacy, monotherapy, and deprescribing: Understanding complex effects on the hepatic proteome of aging mice

  2024cites this paper
• Genome-wide analysis of hepatic DNA methylation reveals impact of epigenetic aging on xenobiotic metabolism and transport genes in an aged mouse model

  2024cites this paper
• Targeting organ-specific mitochondrial dysfunction to improve biological aging.

  2024cites this paper
• 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) Hexanol Inhibits Proliferation and Induces Apoptosis of Endometriosis by Regulating Glutathione S-Transferase Mu Class 4

  2023cites this paper
• Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages of Drug Metabolism and Disposition

  2023cites this paper
• Epigenetic regulation of drug metabolism in aging: utilizing epigenetics to optimize geriatric pharmacotherapy.

  2023cites this paper
• Special Section on Perspective on Drug Metabolism and Disposition, Part I — Minireview Fifty Years of Aryl Hydrocarbon Receptor Research as Reflected in the Pages of Drug Metabolism and Disposition

  2023cites this paper
• Evaluation of the mode of action and human relevance of liver tumors in male mice treated with epyrifenacil.

  2022cites this paper
• Enzymatic Component of the Glutathione System in Russian and Buryat Women Depends on the Menopausal Phase

  2022cites this paper
• Sex Differences in Blood–Brain Barrier Transport of Psychotropic Drugs

  2022cites this paper
• Metabolic protection by the dietary flavonoid 7,8-dihydroxyflavone requires an intact gut microbiome

  2022cites this paper
• Opportunities and Challenges for Nanotherapeutics for the Aging Population

  2022influential citation
• The role of OATP1A1 in cholestasis and drug-induced toxicity: a systematic review

  2022cites this paper
• RNA-Seq unveiled section-specific host response to lack of gut microbiota in mouse intestine.

  2021cites this paper
• Ontogeny of Drug-Metabolizing Enzymes.

  2021cites this paper
• Ageing-associated effects of a long-term dietary modulation of four trace elements in mice

  2021cites this paper
• 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol ameliorates the progression of endometriosis by regulating GSTM4 expression to inhibit proliferation and induce apoptosis

  2021cites this paper
• Comparative hepatotoxicity of a herbicide, epyrifenacil, in humans and rodents by comparing the dynamics and kinetics of its causal metabolite

  2021cites this paper
• Changes in Gene Expression Profiling and Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retina

  2021cites this paper
• Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver.

  2021cites this paper
• Pregnane X Receptor and the Gut-Liver Axis: A Recent Update

  2021influential citation
• Changes in Gene Expression Profiling and Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retinas

  2021cites this paper
• Pedro Ximenez sun-dried grape must: a dietary supplement for a healthy longevity.

  2020cites this paper
• Trimethylamine N-oxide: heart of the microbiota–CVD nexus?

  2020cites this paper
• Gender-differential effects on blood glucose levels between acarbose and metformin in Chinese patients with newly diagnosed type 2 diabetes: a sub-analysis of the MARCH trial.

  2020cites this paper
• Histone acetylation at the sulfotransferase 1a1 gene is associated with its hepatic expression in normal aging

  2020cites this paper
• Trimethylamine-N-Oxide: Heart of the microbiota- cardiovascular disease nexus?

  2020cites this paper
• Age modulates liver responses to asparaginase-induced amino acid stress in mice

  2019cites this paper
• The regulation of drug-metabolizing enzymes and membrane transporters by inflammation: Evidences in inflammatory diseases and age-related disorders

  2018cites this paper
• Determination of Reference Values of MDR‐ABC Transporter Activities in CD3+ Lymphocytes of Healthy Volunteers Using a Flow Cytometry Based Method

  2018cites this paper
• On the safety of repeated ketamine infusions for the treatment of depression: Effects of sex and developmental periods

  2018cites this paper
• PBDE-47 and PBDE mixture (DE-71) toxicities and liver transcriptomic changes at PND 22 after in utero/postnatal exposure in the rat

  2018cites this paper
• Gender-divergent expression of lipid and bile acid metabolism-related genes in adult mice offspring of dams fed a high-fat diet

  2018cites this paper
• Age-associated changes in GSH S-transferase gene/proteins in livers of rats

  2018cites this paper
• Sex Is a Determinant for Deoxynivalenol Metabolism and Elimination in the Mouse

  2017cites this paper
• Calorie restriction effects on circadian rhythms in gene expression are sex dependent

  2017cites this paper
• Ontogeny, aging, and gender‐related changes in hepatic multidrug resistant protein genes in rats

  2017cites this paper
• Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8)[S]

  2017cites this paper
• RNA-Seq Profiling of Intestinal Expression of Xenobiotic Processing Genes in Germ-Free Mice

  2017cites this paper
• Age and sex in drug development and testing for adults

  2017cites this paper
• Age and Sex-Specific Effect of Caloric Restriction on Circadian Clock and Longevity-Associated Gene Expression

  2017cites this paper
• Human Primary Hepatocytes – Product Overview

  2017cites this paper
• Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats

  2016cites this paper
• Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV‐Infected Subjects With Aging Biomarkers

  2016cites this paper
• Concentrations of Pro-Inflammatory Cytokines Are Not Associated with Senescence Marker p16INK4a or Predictive of Intracellular Emtricitabine/Tenofovir Metabolite and Endogenous Nucleotide Exposures in Adults with HIV Infection

  2016cites this paper
• The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

  2016cites this paper
• Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents.

  2016cites this paper
• Tenofovir/Emtricitabine Metabolites and Endogenous Nucleotide Exposures are associated with p16INK4a Expression in Subjects on Combination Therapy

  2016cites this paper
• RNA Sequencing Quantification of Xenobiotic-Processing Genes in Various Sections of the Intestine in Comparison to the Liver of Male Mice

  2016cites this paper
• 3,5-T2 alters murine genes relevant for xenobiotic, steroid, and thyroid hormone metabolism.

  2016cites this paper
• A Genomic Portrait of Hepatitis C Virus and MicroRNA-122

  2015cites this paper
• Impact of sex and age on deoxynivalenol-induced anorexia using a murine model

  2015cites this paper
• Oxidative stress response and Nrf2 signaling in aging.

  2015cites this paper
• Overexpression of Cyclic Adenosine Monophosphate Effluent Protein MRP4 Induces an Altered Response to &bgr;-Adrenergic Stimulation in the Senescent Rat Heart

  2015cites this paper
• Bioavailability of phenolics from an oleuropein-rich olive (Olea europaea) leaf extract and its acute effect on plasma antioxidant status: comparison between pre- and postmenopausal women

  2014cites this paper
• Regulation of ABCG2 Expression in the Lactating Mammary Gland

  2014cites this paper
• Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice.

  2014influential citation
• Age- and sex-related differences of organic anion-transporting polypeptide gene expression in livers of rats.

  2014cites this paper
• X inactivation plays a major role in the gender bias in somatic expansion in a mouse model of the fragile X-related disorders: implications for the mechanism of repeat expansion.

  2014cites this paper
• Analysis of discordant Affymetrix probesets casts serious doubt on idea of microarray data reutilization

  2014cites this paper
• Hormonal regulation of hepatic drug biotransformation and transport systems.

  2013cites this paper
• Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferase have implications in metabolism and clearance of xenobiotics

  2013influential citation
• Effect of Metabolic Disease and Xenobiotic Exposure on Hepatic ATP-Binding Cassette (ABC) Drug Transporter Expression

  2013cites this paper
• Regulation of Xenobiotic and Bile Acid Metabolism by the Anti-aging Intervention Calorie Restriction in Mice

  2013cites this paper
• Differential Regulation of Hepatic Organic Cation Transporter 1, Organic Anion-Transporting Polypeptide 1a4, Bile-Salt Export Pump, and Multidrug Resistance-Associated Protein 2 Transporter Expression in Lymphocyte-Deficient Mice Associates with Interleukin-6 Production

  2013influential citation
• Pharmacokinetics of two common antiretroviral regimens in older HIV‐infected patients: a pilot study

  2013cites this paper