Copper‐Catalyzed (3+2) Annulation of 5‐Ethynyloxazolidine‐2,4‐diones with Benzoylacetonitriles: Synthesis of Dihydrofuran Derivatives

The copper‐catalyzed (3+2) annulation of 5‐ethynyloxazolidine‐2,4‐diones with acylacetonitriles worked well under mild reaction conditions to afford biologically important 2,3‐dihydrofuran derivatives having an amide moiety in moderate to high yields. A wide scope of easily accessible 5‐ethynyloxazolidine‐2,4‐diones and acylacetonitriles were tolerated. The successful scale‐up reaction demonstrated that the reaction is a useful method for the synthesis of 2,3‐dihydrofuran derivatives.

• Publication year

  2023

• Venue

  ChemistrySelect

• Publication date

  2023-10-18

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1002/slct.202303126
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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• No concepts are published for this paper.

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