Activation-Independent Cyclization of Monoterpenoids

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Applied and Environmental Microbiology

• Publication date

  2011-12-09

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1128/AEM.07059-11PMID 22156419PMCID PMC3273027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Enzymes of the mevalonate pathway of isoprenoid biosynthesis.

  2011cited by this paper
• Squalene-Hopene Cyclases

  2011cited by this paper
• RACK1, A multifaceted scaffolding protein: Structure and function

  2011cited by this paper
• One pot synthesis of menthol from (±)-citronellal on nickel sulfated zirconia catalysts

  2011cited by this paper
• MCCE2: Improving protein pKa calculations with extensive side chain rotamer sampling

  2009influential reference
• Asymmetric alkene reduction by yeast old yellow enzymes and by a novel Zymomonas mobilis reductase

  2007cited by this paper
• Enzymatic reduction of the α, β-unsaturated carbon bond in citral

  2006cited by this paper
• Asymmetric whole-cell bioreduction of an α,β-unsaturated aldehyde (citral): competing prim-alcohol dehydrogenase and C–C lyase activities

  2006cited by this paper
• Domino-cyclisation and hydrogenation of citronellal to menthol over bifunctional Ni/Zr-Beta and Zr-beta/Ni-MCM-41 catalysts.

  2006cited by this paper
• Cation-pi interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase.

  2006cited by this paper
• Access of the substrate to the active site of squalene and oxidosqualene cyclases: comparative inhibition, site-directed mutagenesis and homology-modelling studies.

  2005cited by this paper
• (−)-Menthol biosynthesis and molecular genetics

  2005cited by this paper
• Protein structure prediction servers at University College London

  2005cited by this paper
• The Changing Path of Hopanoid Research: From Condensing Lipids to New Membrane Enzymes

  2005cited by this paper
• Squalene-hopene cyclase: insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of squalene analogs lacking a 26-methyl group and possessing a methyl group at C7 or C11.

  2004cited by this paper
• Conversion of squalene to the pentacarbocyclic hopene.

  2004cited by this paper
• Enzymatic cyclization reactions of geraniol, farnesol and geranylgeraniol, and those of truncated squalene analogs having C20 and C25 by recombinant squalene cyclase.

  2004cited by this paper
• Squalene-hopene cyclase: catalytic mechanism and substrate recognition.

  2002cited by this paper
• Structural diversity of the triterpenic hydrocarbons from the bacterium Zymomonas mobilis: the signature of defective squalene cyclization by the squalene/hopene cyclase.

  2001cited by this paper
• Cyclisation of Citronellal to Isopulegol Catalysed by Hydrous Zirconia and Other Solid Acids

  2001cited by this paper
• Isomerization of Citronellal to Isopulegol Using Eclectically Engineered Sulfated Zirconia−Carbon Molecular Sieve Composite Catalysts, UDCaT-2

  2000cited by this paper
• Cyclization Enzymes in the Biosynthesis of Monoterpenes, Sesquiterpenes, and Diterpenes

  2000cited by this paper
• Enzyme Mechanisms for Polycyclic Triterpene Formation.

  2000cited by this paper
• Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.

  2000cited by this paper
• Conserved tyr residues determine functions of Alicyclobacillus acidocaldarius squalene-hopene cyclase.

  2000influential reference
• Functional analysis of the DXDDTA motif in squalene-hopene cyclase by site-directed mutagenesis experiments: initiation site of the polycyclization reaction and stabilization site of the carbocation intermediate of the initially cyclized A-ring.

  1999cited by this paper
• The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution.

  1999cited by this paper
• Plant terpenoid synthases: molecular biology and phylogenetic analysis.

  1998cited by this paper
• Structure and function of a squalene cyclase.

  1997cited by this paper
• Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol.

  1997cited by this paper
• Thirty years of environmental health research--and growing.

  1996cited by this paper
• A fast flexible docking method using an incremental construction algorithm.

  1996cited by this paper
• Zymomonas mobilis squalene-hopene cyclase gene (shc): cloning, DNA sequence analysis, and expression in Escherichia coli.

  1995cited by this paper
• Comparative protein modelling by satisfaction of spatial restraints.

  1993cited by this paper
• Biochemistry and physiology of hopanoids in bacteria.

  1993cited by this paper
• Purification, partial characterization and substrate specificity of a squalene cyclase from Bacillus acidocaldarius.

  1986cited by this paper
• Enzyme Mechanisms

  1967cited by this paper

• A New Age of Biocatalysis Enabled by Generic Activation Modes

  2024cites this paper
• Controlling Monoterpene Isomerization by Guiding Challenging Carbocation Rearrangement Reactions in Engineered Squalene-Hopene Cyclases.

  2024cites this paper
• Class II terpene cyclases: structures, mechanisms, and engineering.

  2023cites this paper
• Asymmetric Cation‐Olefin Monocyclization by Engineered Squalene–Hopene Cyclases

  2021cites this paper
• Enzymatic Friedel‐Crafts Alkylation Using Squalene‐Hopene Cyclases

  2021cites this paper
• Engineering of Yeast Old Yellow Enzyme OYE3 Enables Its Capability Discriminating of (E)-Citral and (Z)-Citral

  2021cites this paper
• A Novel Soluble Squalene-Hopene Cyclase and Its Application in Efficient Synthesis of Hopene

  2020cites this paper
• Broadening the scope of biocatalytic C–C bond formation

  2020cites this paper
• Enzymes revolutionize the bioproduction of value-added compounds: From enzyme discovery to special applications.

  2020cites this paper
• Current Advances in the Bacterial Toolbox for the Biotechnological Production of Monoterpene-Based Aroma Compounds

  2020cites this paper
• Transcriptome mining of squalene cyclases in Lygodium japonicum

  2020cites this paper
• Distinct metabolic pathways drive monoterpenoid biosynthesis in a natural population of Pelargonium graveolens

  2019cites this paper
• Linear enzyme cascade for the production of (–)-iso-isopulegol

  2019cites this paper
• Engineering the “Missing Link” in Biosynthetic (−)-Menthol Production: Bacterial Isopulegone Isomerase

  2018cites this paper
• Directed Evolution of Protein Catalysts.

  2018cites this paper
• First Draft Genome of a Brazilian Atlantic Rainforest Burseraceae reveals commercially-promising genes involved in terpenic oleoresins synthesis

  2018cites this paper
• Enzymatic Addition of Alcohols to Terpenes by Squalene Hopene Cyclase Variants

  2017cites this paper
• Production of functionalized oligo‐isoprenoids by enzymatic cleavage of rubber

  2017cites this paper
• Selectivity in the Cyclization of Citronellal Introduced by Squalene Hopene Cyclase Variants

  2017cites this paper
• Studien zum Einsatz von enzymatischen Lewis- und Brønsted-Säuren in Carbonyl-aktiviertenorganischen Reaktionen

  2016cites this paper
• Migrated Hopene Synthases from Colysis pothifolia and Identification of a Migration Switch Controlling the Number of 1,2‐Hydride and Methyl Shifts

  2016cites this paper
• Squalene-hopene cyclases-evolution, dynamics and catalytic scope.

  2016cites this paper
• Flexibility unleashed in acyclic monoterpenes: conformational space of citronellal revealed by broadband rotational spectroscopy.

  2016cites this paper
• Substrate Pre‐Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates

  2016cites this paper
• Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution.

  2015cites this paper
• Role of adsorption in catalysis : applications of NMR relaxometry

  2015cites this paper
• Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis.

  2015cites this paper
• Ausdehnung des Enzym‐Universums: Zugang zu nicht‐natürlichen Reaktionen durch mechanismusgeleitete, gerichtete Evolution

  2015cites this paper
• Activity of squalene-hopene cyclases in bicontinuous microemulsions.

  2015cites this paper
• The effect of host structure on the selectivity and mechanism of supramolecular catalysis of Prins cyclizations

  2014cites this paper
• Development of Sustainable Biocatalytic Reduction Processes for Organic Chemists

  2013cites this paper
• Characterization of the substrate specificity of squalene-hopene cyclases (SHCs)

  2013cites this paper
• High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase.

  2013cites this paper
• Schlummerndes Synthesepotenzial in Enzymen: Wie können wir es wecken?

  2013cites this paper
• Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective CC and CX bond formation.

  2013cites this paper
• Prokaryotic squalene-hopene cyclases can be converted to citronellal cyclases by single amino acid exchange

  2013cites this paper
• Synthesis of Heterocyclic Terpenoids by Promiscuous Squalene–Hopene Cyclases

  2013cites this paper
• Stereoselective Friedel–Crafts alkylation catalyzed by squalene hopene cyclases

  2012cites this paper
• Substrate specificity of a novel squalene-hopene cyclase from Zymomonas mobilis

  2012cites this paper
• The triterpene cyclase protein family: A systematic analysis

  2012cites this paper
• Oral 1.3.01Industrial biotechnology: directing innovation in chemistry

  2012cites this paper
• Procédé de cyclisation biocatalytique de terpènes et mutants de cyclases pouvant être utilisés dans ce procédé

  2011cites this paper