A systematic review to investigate whether birth weight affects the autonomic nervous system in adulthood

ABSTRACT Objective: To evaluate the relationship between birth weight and the autonomic nervous system in adulthood through a systematic review. Data source: This is a systematic review of publications without limitation of year and language. We included studies involving the autonomic nervous system and birth weight in adults. Manuscripts were selected based on electronic searches of Medical Literature Analysis and Retrieval System Online (MEDLINE), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science Cochrane Library and Scopus databases, using “Autonomic Nervous System” OR “Heart Rate” OR “Heart Rate Variability” AND “Birth Weight” as a search strategy. This review is registered on the International Prospective Register of Systematic Reviews — PROSPERO (ID: CRD42020165622). Data synthesis: We found 894 articles; 215 were excluded for duplicity. Of the remaining 679 studies, 11 remained. Two were excluded because they did not specifically treat the autonomic nervous system or birth weight. There were nine publications, two cohort and seven cross-sectional studies. The main findings were that extreme, very low, low or high birth weight may have some impact on the autonomic nervous system in adult life. Conclusions: Birth weight outside the normality rate may have a negative influence on the autonomic nervous system, causing autonomic dysfunction and increasing the risk of cardiovascular diseases in adult life. Thus, the importance of the follow-up of health professionals from pregnancy to gestation and throughout life, with preventive care being emphasized.

• Publication year

  2023

• Venue

  Revista Paulista de Pediatria

• Publication date

  2023-11-03

• Fields of study

  Medicine

• Identifiers
  DOI 10.1590/1984-0462/2024/42/2023002PMID 37937677PMCID 10627483
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diretrizes Brasileiras de Hipertensão Arterial – 2020

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  2019influential reference
• Association of Early-Life Factors With Life-Course Trajectories of Resting Heart Rate: More Than 6 Decades of Follow-up

  2018cited by this paper
• Association between autonomic control indexes and mortality in subjects admitted to intensive care unit

  2018cited by this paper
• Impaired autonomic function in adolescents born preterm

  2018cited by this paper
• Autonomic nervous system in newborns: a review based on heart rate variability

  2017cited by this paper
• Influence of sympathetic activity in the control of peripheral microvascular tone in preterm infants

  2016cited by this paper
• The association of birth weight and infant growth with childhood autonomic nervous system activity and its mediating effects on energy-balance-related behaviours-the ABCD study.

  2016cited by this paper
• Association between Birth Characteristics and Cardiovascular Autonomic Function at Mid-Life

  2016influential reference
• Blunted Autonomic Responses and Low-Grade Inflammation in Mongolian Adults Born at Low Birth Weight.

  2016influential reference
• Reduced respiratory sinus arrhythmia in adults born at extremely low birth weight: evidence of premature parasympathetic decline?

  2014cited by this paper
• Olanzapine-induced weight gain plays a key role in the potential cardiovascular risk: evidence from heart rate variability analysis

  2014cited by this paper
• The development of autonomic cardiovascular control is altered by preterm birth.

  2013cited by this paper
• Does preterm birth influence cardiovascular risk in early adulthood?

  2012cited by this paper
• Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association

  2009cited by this paper
• Size at Birth and Autonomic Function During Psychological Stress

  2007influential reference
• Size at birth and cardiovascular responses to psychological stressors: evidence for prenatal programming in women

  2004influential reference
• Birth prematurity determines prolonged autonomic nervous system immaturity

  2004cited by this paper
• Evidence for lower sympathetic nerve activity in young adults with low birth weight

  2003influential reference
• Coronary heart disease: reducing the risk: the scientific background to primary and secondary prevention of coronary heart disease. A worldwide view. International Task force for the Prevention of Coronary Heart disease.

  1999cited by this paper
• Association between low birthweight and high resting pulse in adult life: is the sympathetic nervous system involved in programming the insulin resistance syndrome?

  1997cited by this paper
• Patterns of human fetal heart rate accelerations from 26 weeks to term.

  1987cited by this paper
• The intrinsic physiologic properties of the developing heart.

  1972cited by this paper

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  2025cites this paper
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  2025cites this paper