Heparan sulfate-based treatments for regenerative medicine.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Critical Reviews in Eukaryotic Gene Expression

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1615/CRITREVEUKARGENEEXPR.V21.I1.10PMID 21967329
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• [Acceleration of the regeneration of skeletal muscles in adult rats by dextran derivatives].

  1995cited by this paper
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  1995cited by this paper
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  1990cited by this paper
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