Oral Lichen Planus: Relation with Transaminase Levels and Diabetes

Increase of transaminase levels was reported earlier in patients with oral lichen planus. A study was conducted in the department to assess the liver function status (transaminase levels) in oral lichen planus patients and any influence of diabetes mellitus on such cases.Study was performed on 20 patients with different types of oral lichen planus as a study group and 20 control healthy group. Age and sex was randomly selected. All the patients were subjected to routine blood tests and urine analysis and the estimation of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels. The values of SGOT and SGPT levels =< 40 iu/L were considered within normal limits.Seven patients (35%) with oral lichen planus had diabetes mellitus while three (15%) cases of the control group had diabetes mellitus (p = 0.04). Regarding SGOT and SGPT levels, it was elevated in 11(55%) cases and in 2 cases (10%) of the study group and control group respectively (p < 0.001). In relation to the type of oral lichen planus out of 8 erosive cases, 87.5%(7 cases) showed elevated SGOT/SGPT levels out of 12 nonerosive cases, 33.33% (4 cases) showed elevated SGOT/SGPT levels (p < 0.01).We hence conclude that diabetes mellitus and elevated transaminase levels might be related to the development of oral lichen planus lesions. There is a strong association between elevated SGOT/SGPT levels and detection of erosive type of oral lichen planus.

• Publication year

  2010

• Venue

  Journal of Indian Academy of Oral Medicine and Radiology

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.5005/JP-JOURNALS-10011-1001
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Oral lichen planus in relation to transaminase levels and hepatitis C virus.

  2007cited by this paper
• Oral Lichen Planus in Childhood

  2005cited by this paper
• Oral fungal infections.

  2005cited by this paper
• Prevalence rate of candida in the oral cavity of patients with oral lichen planus

  2004cited by this paper
• Oral lichen planus in childhood

  1994cited by this paper
• Oral lichen planus and chronic liver disease: a clinical and morphometric study of the oral lesions in relation to transaminase elevation.

  1994cited by this paper
• Lichen planus: exploring its malignant potential.

  1993cited by this paper
• Lichenoid lesions of oral mucosa. Diagnostic criteria and their importance in the alleged relationship to oral cancer.

  1992cited by this paper
• LICHEN PLANUS AND THE LIVER

  1992cited by this paper
• Relation of stress and anxiety to oral lichen planus.

  1986cited by this paper
• Oral erosive lichen planus and chronic liver disease.

  1986cited by this paper
• Lichen planus and liver disease: how strong is the association?

  1985cited by this paper
• Liver abnormalities in patients with lichen planus. A retrospective case-control study.

  1984cited by this paper
• Lichen Planus and Liver Disease

  1984cited by this paper
• Lichen planus: a theory of pathogenesis.

  1983cited by this paper
• Lichen planus as an oral ulcerative disease.

  1972cited by this paper
• The variations and course of lichen planus.

  1961cited by this paper

• No citing papers are available for this paper.