Injectable 3D microcultures enable intracerebral transplantation of mature neurons directly reprogrammed from patient fibroblasts

No abstract is available for this paper.

• Publication year

  2023

• Venue

  bioRxiv

• Publication date

  2023-12-10

• Fields of study

  Biology, Medicine, Engineering

• Identifiers
  DOI 10.1101/2023.12.10.570992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Generation of functional human oligodendrocytes from dermal fibroblasts by direct lineage conversion

  2022cited by this paper
• Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease

  2022cited by this paper
• Transcription factor-based direct conversion of human fibroblasts to functional astrocytes

  2022cited by this paper
• D biomaterial models of human brain disease

  2021cited by this paper
• Reprogramming Human Adult Fibroblasts into GABAergic Interneurons

  2021influential reference
• Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease

  2021cited by this paper
• Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

  2021cited by this paper
• Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors

  2021cited by this paper
• One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2

  2021cited by this paper
• Direct cell reprogramming: approaches, mechanisms and progress

  2021cited by this paper
• 3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo.

  2020cited by this paper
• Sequence Analysis

  2020cited by this paper
• Injectable Therapeutic Organoids Using Sacrificial Hydrogels

  2020cited by this paper
• RNAAgeCalc: A multi-tissue transcriptional age calculator

  2020cited by this paper
• High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

  2020cited by this paper
• A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice

  2018influential reference
• Rapid and efficient induction of functional astrocytes from human pluripotent stem cells

  2018cited by this paper
• NeuroMatic: An Integrated Open-Source Software Toolkit for Acquisition, Analysis and Simulation of Electrophysiological Data

  2018influential reference
• Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts

  2018influential reference
• SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

  2018cited by this paper
• Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

  2018cited by this paper
• Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

  2018cited by this paper
• Fused cerebral organoids model interactions between brain regions

  2017cited by this paper
• REST suppression mediates neural conversion of adult human fibroblasts via microRNA‐dependent and ‐independent pathways

  2017influential reference
• Assembly of functionally integrated human forebrain spheroids

  2017cited by this paper
• Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

  2017cited by this paper
• Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

  2016cited by this paper
• MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons

  2015cited by this paper
• Rapid Conversion of Fibroblasts into Functional Forebrain GABAergic Interneurons by Direct Genetic Reprogramming.

  2015influential reference
• Human Cardiac Progenitor Spheroids Exhibit Enhanced Engraftment Potential

  2015cited by this paper
• Analytic Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids

  2015cited by this paper
• Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

  2015cited by this paper
• Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

  2014cited by this paper
• An injectable spheroid system with genetic modification for cell transplantation therapy.

  2014cited by this paper
• Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors

  2014cited by this paper
• Cerebral organoids model human brain development and microcephaly

  2013cited by this paper
• Small Molecules Enable Neurogenin 2 to Efficiently Convert Human Fibroblasts to Cholinergic Neurons

  2013cited by this paper
• Cortical representations of olfactory input by trans-synaptic tracing

  2011cited by this paper
• Direct conversion of human fibroblasts to dopaminergic neurons

  2011cited by this paper
• Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

  2011cited by this paper
• REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

  2011cited by this paper
• Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

  2011cited by this paper
• Gene ontology analysis for RNA-seq: accounting for selection bias

  2010cited by this paper
• Gene expression maSigPro : a method to identify significantly differential expression profiles in time-course microarray experiments

  2006cited by this paper
• Ionic Mechanisms Underlying Autonomous Action Potential Generation in the Somata and Dendrites of GABAergic Substantia Nigra Pars Reticulata Neurons In Vitro

  2005cited by this paper
• Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

  1997cited by this paper
• Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways.

  1993cited by this paper

• Direct conversion of human umbilical cord mesenchymal stem cells into dopaminergic neurons for Parkinson's disease treatment.

  2024influential citation
• Bioreactor-produced iPSCs-derived dopaminergic neuron-containing neural microtissues innervate and normalize rotational bias in a dose-dependent manner in a Parkinson rat model

  2024cites this paper