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Evaluation of pancreatic lipase and angiotensin-converting enzyme inhibitors from ethanolic extract of butterfly pea (Clitoria ternatea L.) flowers

Ratna Djamil,Diah Kartika Pratami,Tia Novia Wilantika,Qurrata A’yun,Abdul Mun’im,A. Bayu,M. Putra

Published 2024 in Journal of Applied Biology & Biotechnology

ABSTRACT

Clitoria ternatea L. (CT) contains flavonoids, saponins, tannins, coumarins, steroids/triterpenoids, and essential oils. CT flowers have been used for ages to maintain good health in the Indonesian community. Based on the empirical use of CT, scientific studies are needed to establish its therapeutic values. The objectives of this research were to examine the quality parameters and analyze the activities of CT as antihyperlipidemic and antihypertensive in vitro . The total phenolic contents (TPC) and total flavonoid contents (TFC), as well as specific (identity, organoleptic examination, and the percentage of soluble compounds in certain solvents) and non-specific (water content, loss on drying, ash content, residual solvent, heavy metal, and microbial contamination) quality parameters were also evaluated. The antihyperlipidemic and antihypertensive activities were determined using lipase enzyme inhibition and angiotensin-converting enzyme (ACE) inhibition activity. The TPC and TFC of ethanolic extract of CT (EECT) were 38.30 ± 4.50 mg gallic acid equivalent/g extract and 29.379 ± 0.31 mg quercetin equivalent/g extract. The determined parameters satisfy the quality and safety requirements of the medicinal herb standard. The IC 50 values of the lipase enzyme and ACE inhibition of EECT were 131.79 ± 5.27 µ g/mL and 84.9653 ppm, respectively. CT extract inhibits both the lipase and ACE enzymes. The EECT has potential as an antihyperlipidemic and antihypertensive agent.

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