Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neuro-Oncology

• Publication date

  2008-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1215/15228517-2007-051PMID 18314418PMCID PMC2613816
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibitory mechanisms of tetramethylpyrazine in middle cerebral artery occlusion (MCAO)-induced focal cerebral ischemia in rats.

  2006cited by this paper
• Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats.

  2006cited by this paper
• Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

  2005cited by this paper
• Effect of tetramethylpyrazine on potassium channels to lower calcium concentration in cultured aortic smooth muscle cells

  2003cited by this paper
• Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes.

  2003cited by this paper
• Iron-induced oxidative damage and apoptosis in cerebellar granule cells: attenuation by tetramethylpyrazine and ferulic acid.

  2003cited by this paper
• Mechanisms responsible for the in vitro relaxation of ligustrazine on porcine left anterior descending coronary artery.

  2003cited by this paper
• Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

  2002cited by this paper
• Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells.

  2002cited by this paper
• Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture

  2002cited by this paper
• Studies on single-cell adhesion probability between lymphocytes and endothelial cells with micropipette technique.

  2002cited by this paper
• Pharmacokinetics of tetramethylpyrazine in rat blood and brain using microdialysis.

  2001cited by this paper
• Glutamate release promotes growth of malignant gliomas

  2001cited by this paper
• Differential expression and localization of TIMP-1 and TIMP-4 in human gliomas

  2001cited by this paper
• The antiplatelet activity of tetramethylpyrazine is mediated through activation of NO synthase.

  2000cited by this paper
• Gene therapy of experimental brain tumors using neural progenitor cells

  2000cited by this paper
• Time course of transient expression of GDNF protein in rat granule cells of the bilateral dentate gyri after unilateral intrahippocampal kainic acid injection.

  1999cited by this paper
• Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells.

  1999cited by this paper
• Glioma cells release excitotoxic concentrations of glutamate.

  1999cited by this paper
• Formation of free hydroxyl radicals after pentylenetetrazol-induced seizure and kindling.

  1999cited by this paper
• Mammary carcinoma cells over-expressing tissue inhibitor of metalloproteinases-1 show enhanced vascular endothelial growth factor expression.

  1998cited by this paper
• Glutamate receptor activation can trigger electrical activity in human glioma cells

  1998cited by this paper
• Mammary carcinoma cells over‐expressing tissue inhibitor of metalloproteinases‐1show vascular endothelial growth factor expression

  1998cited by this paper
• Effects of tetramethylpyrazine on the release of PGI2 and TXA2 in the hypoxic isolated rat heart

  1997cited by this paper
• Generation of lipid radicals in the hippocampal extracellular space during kainic acid-induced seizures in rats.

  1997cited by this paper
• Tetramethylpyrazine, a Calcium Antagonist

  1996cited by this paper
• [Effect of tetramethyl pyrazine on coronary vasoconstriction induced by endothelin-1 in dogs].

  1996cited by this paper
• Calcium-dependent free radical generation in cultured retinal neurons injured by kainate.

  1995cited by this paper
• Effect of tetramethylpyrazine in inhibiting respiratory burst of polymorphonuclears and scavenging oxygen free radicals

  1994cited by this paper
• [Effect of tetramethylpyrazine in inhibiting respiratory burst of polymorphonuclears and scavenging oxygen free radicals].

  1994cited by this paper
• Plant‐derived drugs acting on cellular ca2+ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine

  1994cited by this paper
• Glutamate receptors and the induction of excitotoxic neuronal death.

  1994cited by this paper
• Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons

  1994cited by this paper
• [Protective effect of tetramethylpyrazine on ischemic neuronal damage in the gerbil hippocampus].

  1994cited by this paper
• Oxidative stress induced by glutamate receptor agonists.

  1993cited by this paper
• Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells.

  1993cited by this paper
• Ultrastructural localization and fluctuation in the level of the proliferating cell nuclear antigen and myc oncoproteins in synchronized neuroblastoma cells.

  1993cited by this paper
• [Effects of tetramethylpyrazine on the cardiovascular system].

  1992cited by this paper
• Effects of tetramethylpyrazine on the cardiovascular system

  1992cited by this paper
• Growth stimulation of human keratinocytes by tissue inhibitor of metalloproteinases.

  1991cited by this paper
• Inhibition of Vasoconstriction by Tetramethylpyrazine: Does It Act by Blocking the Voltage‐Dependent Ca Channel?

  1990cited by this paper
• Ligustrazine is a vasodilator of human pulmonary and bronchial arteries.

  1990cited by this paper
• Tetramethylpyrazine for treatment of experimentally induced stroke in Mongolian gerbils.

  1989cited by this paper
• Molecular characterization and expression of the gene encoding human erythroid-potentiating activity

  1985cited by this paper
• Control of rat C6 glioma cell proliferation: uncoupling of the inhibitory effects of hydrocortisone hormone in suspension and monolayer cultures

  1983cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• GFA expression in aggregating cultures of rat C6 glioma

  1979cited by this paper

• Danshensu Derivatives: A Series of Promising Drugs With Protective Effects Against Cardiocerebrovascular Diseases and Cancers

  2025cites this paper
• Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

  2025cites this paper
• 3D Bioprinting Models for Glioblastoma: From Scaffold Design to Therapeutic Application

  2025cites this paper
• Bibliometric analysis of research progress on tetramethylpyrazine and its effects on ischemia-reperfusion injury.

  2024cites this paper
• A comprehensive review of quantified flavour components in Chinese baijiu

  2024cites this paper
• Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling.

  2023cites this paper
• Discovery of Novel Tetramethylpyrazine containing Chalcone Derivatives as Anti-Inflammatory Agents.

  2023cites this paper
• Biomimetic three-dimensional glioma model printed in vitro for the studies of glioma cells and neurons interactions

  2023cites this paper
• Exploring the Vital Link Between Glioma, Neuron, and Neural Activity in the Context of Invasion.

  2023cites this paper
• Design and Fabrication of Nanofibrous Dura Mater with Antifibrosis and Neuroprotection Effects on SH-SY5Y Cells

  2022cites this paper
• Tetramethylpyrazine induces the release of BDNF from BM‐MSCs through activation of the PI3K/AKT/CREB pathway

  2021cites this paper
• Mechanistic insight into immunomodulatory effects of food-functioned plant secondary metabolites

  2021cites this paper
• Tetramethylpyrazine: A Review of Its Antitumor Potential and Mechanisms

  2021influential citation
• VERAPAMIL-HYDROCHLORIDE AT LOW CONCENTRATIONS INHIBITS THE GROWTH OF RELAPSE GLIOBLASTOMA

  2019cites this paper
• The first experience of combined treatment of brain malignant gliomas by means of blocking membrane calcium channels

  2019influential citation
• Tetramethylpyrazine protects retinal ganglion cells against H2O2-induced damage via the microRNA-182/mitochondrial pathway

  2019cites this paper
• Pyrazines in Food

  2019cites this paper
• Ligustrazine Enhances the Hypnotic and Analgesic Effect of Ketamine in Mice.

  2018cites this paper
• Tetramethylpyrazine regulates breast cancer cell viability, migration, invasion and apoptosis by affecting the activity of Akt and caspase-3.

  2018cites this paper
• Extracts of Cerbera manghas L. effectively inhibit the viability of glioblastoma cell lines and their cancer stemloids in vitro and in mouse xenograft model

  2018cites this paper
• Tetramethylpyrazine (TMPZ) triggers S-phase arrest and mitochondria-dependent apoptosis in lung cancer cells.

  2018cites this paper
• Tetramethylprazine, a Potential Adjuvent to Inhibit Cancer Metastasis through CXCR4/SDF-1 pathway

  2017cites this paper
• Tetramethylpyrazine inhibits prostate cancer progression by downregulation of forkhead box M1

  2017influential citation
• Potent Anti-Inflammatory Activity of Tetramethylpyrazine Is Mediated through Suppression of NF-k

  2016cites this paper
• Tetramethylpyrazine Attenuates Transdifferentiation of TGF-β2-Treated Human Tenon's Fibroblasts.

  2016cites this paper
• The Reversal Effect and Its Mechanisms of Tetramethylpyrazine on Multidrug Resistance in Human Bladder Cancer

  2016cites this paper
• XuefuZhuyu Tang exerts antitumor effects by inhibiting glioma cell metastasis and invasion via regulating tumor microenvironment

  2016cites this paper
• Ligustrazine Suppresses the Growth of HRPC Cells through the Inhibition of Cap- Dependent Translation Via Both the mTOR and the MEK/ERK Pathways.

  2015cites this paper
• Ligustrazine monomer against cerebral ischemia/reperfusion injury

  2015cites this paper
• Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis

  2015cites this paper
• Tetramethylpyrazine induces SH-SY5Y cell differentiation toward the neuronal phenotype through activation of the PI3K/Akt/Sp1/TopoIIβ pathway.

  2015cites this paper
• CXC195 suppresses proliferation and inflammatory response in LPS-induced human hepatocellular carcinoma cells via regulating TLR4-MyD88-TAK1-mediated NF-κB and MAPK pathway.

  2015cites this paper
• CXC195 induces apoptosis and endoplastic reticulum stress in human hepatocellular carcinoma cells by inhibiting the PI3K/Akt/mTOR signaling pathway.

  2015cites this paper
• Cerebral microdialysis in glioma studies, from theory to application.

  2014cites this paper
• Inhibition of Angiogenesis, Fibrosis and Thrombosis by Tetramethylpyrazine: Mechanisms Contributing to the SDF-1/CXCR4 Axis

  2014cites this paper
• Tetramethylpyrazine promotes SH-SY5Y cell differentiation into neurons through epigenetic regulation of Topoisomerase IIβ.

  2014cites this paper
• Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism

  2014cites this paper
• Induced interleukin-33 expression enhances the tumorigenic activity of rat glioma cells.

  2014cites this paper
• Tetramethylpyrazine inhibits osteosarcoma cell proliferation via downregulation of NF-κB in vitro and in vivo.

  2013cites this paper
• Utilizing SPR as a Novel Technique to Measure Cell Aggregation for Ketamine Treated Brain Gliomas

  2013influential citation
• Tetramethylpyrazine (TMP) protects cerebral neurocytes and inhibits glioma by down regulating chemokine receptor CXCR4 expression.

  2013cites this paper
• Indanostatin, a new neuroprotective compound from Streptomyces sp.

  2013cites this paper
• Tetramethylpyrazine-mediated suppression of C6 gliomas involves inhibition of chemokine receptor CXCR4 expression.

  2012cites this paper
• Tounongsan (透脓散) extract induces apoptosis in cultured Raji cells

  2012cites this paper
• Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells

  2012cites this paper
• A modified LC-MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home-made linear probes.

  2012cites this paper
• Stimulating Expansion and International Recognition: Translational Medicine

  2011cites this paper
• Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways.

  2011cites this paper
• Tetramethylpyrazine inhibits production of nitric oxide and inducible nitric oxide synthase in lipopolysaccharide-induced N9 microglial cells through blockade of MAPK and PI3K/Akt signaling pathways, and suppression of intracellular reactive oxygen species.

  2010cites this paper
• Alleviation of CCl4-induced cirrhosis in rats by tetramethylpyrazine is associated with downregulation of leptin and TGF-β1 pathway

  2010cites this paper
• In reference to Fu et al. (neuro-Oncology 2008:10139-152).

  2009cites this paper
• Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial.

  2009cites this paper
• The effect of tetramethylpyrazine on hydrogen peroxide-induced oxidative damage in human umbilical vein endothelial cells.

  2009cites this paper
• Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.

  2008cites this paper