Non-proteolytic ubiquitination of HBx controls HBV replication

Highlights • The expression level of TRIM21 in patients is negatively correlated with the replication and integration of HBV.• TRIM21 was found to trigger non-proteolytic ubiquitination of X protein of HBV.• This study proposes that the PRYSPRY and RING domains in TRIM21 dimer can form a docking conformation for HBx binding.• TRIM21-mediated HBx ubiquitination disrupts the DDB1 recruitment to HBx and stabilize Smc6.

• Publication year

  2024

• Venue

  Virologica Sinica

• Publication date

  2024-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.virs.2024.01.008PMID 38307415PMCID 11074638
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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