Affinity-independent plasma cell differentiation in germinal centers.

The role of antibody affinity in plasma cell (PC) differentiation from germinal centers (GCs) remains contested. Parallel studies by Sprumont et al. and Sutton and Gao et al. show that PCs emerging from GCs produce antibodies with a diverse range of affinities and lack signatures of affinity-based selection. Therefore, commitment to the PC lineage is affinity independent.

• Publication year

  2024

• Venue

  Trends in immunology

• Publication date

  2024-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.it.2024.03.002PMID 38521715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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