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Perspective—Surface-display Techniques in Electrochemical Biosensor Designs for Health Monitoring

Courtney J. Weber,Megan D. Whisonant,Olivia M. Clay,Olja Simoska

Published 2024 in ECS Sensors Plus

ABSTRACT

Enzymatic and microbial electrochemical biosensors integrate enzymes and microorganisms as biological recognition elements into the sensor design and functionality. Enzyme-based sensors offer high sensitivity and selectivity for target analyte detection. However, these have limited stability necessary for continuous analyte monitoring. Contrarily, microbe-based electrochemical sensors provide a means for continuous analyte sensing but are associated with challenges related to analyte selectivity in complex samples. To address these limitations, surface-display methods, which bind enzymes to microbial surfaces, enhance biosensor selectivity and sensitivity. This perspective outlines the application of surface-display techniques, offering a promising avenue for health monitoring.

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