A Stochastic Dynamic Operator Framework That Improves the Precision of Analysis and Prediction Relative to the Classical Spike-Triggered Average Method, Extending the Toolkit

Here we test the stochastic dynamic operator (SDO) as a new framework for describing physiological signal dynamics relative to spiking or stimulus events. The SDO is a natural extension of existing spike-triggered average (STA) or stimulus-triggered average techniques currently used in neural analysis. It extends the classic STA to cover state-dependent and probabilistic responses where STA may fail. In simulated data, SDO methods were more sensitive and specific than the STA for identifying state-dependent relationships. We have tested SDO analysis for interactions between electrophysiological recordings of spinal interneurons, single motor units, and aggregate muscle electromyograms (EMG) of major muscles in the spinal frog hindlimb. When predicting target signal behavior relative to spiking events, the SDO framework outperformed or matched classical spike-triggered averaging methods. SDO analysis permits more complicated spike–signal relationships to be captured, analyzed, and interpreted visually and intuitively. SDO methods can be applied at different scales of interest where spike-triggered averaging methods are currently employed, and beyond, from single neurons to gross motor behaviors. SDOs may be readily generated and analyzed using the provided SDO Analysis Toolkit. We anticipate this method will be broadly useful for describing dynamical signal behavior and uncovering state-dependent relationships of stochastic signals relative to discrete event times.

• Publication year

  2024

• Venue

  eNeuro

• Publication date

  2024-05-12

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1523/ENEURO.0512-23.2024PMID 39375031PMCID 11552545
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Forces Generated by Agonist Muscles during Isometric Contractions Arise from Motor Unit Synergies

  2023cited by this paper
• Integrated neural dynamics of sensorimotor decisions and actions

  2022cited by this paper
• Common synaptic inputs are not distributed homogeneously among the motor neurons that innervate synergistic muscles

  2022cited by this paper
• Common synaptic input, synergies and size principle: Control of spinal motor neurons for movement generation

  2022cited by this paper
• Movement is governed by rotational neural dynamics in spinal motor networks

  2022cited by this paper
• Single-cell and ensemble activity of lumbar intermediate and ventral horn interneurons in the spinal air-stepping cat

  2021cited by this paper
• Highly Flexible Precisely Braided Multielectrode Probes and Combinatorics for Future Neuroprostheses

  2019cited by this paper
• Precise Tubular Braid Structures of Ultrafine Microwires as Neural Probes: Significantly Reduced Chronic Immune Response and Greater Local Neural Survival in Rat Cortex

  2019influential reference
• State-dependent rhythmogenesis and frequency control in a half-center locomotor CPG.

  2018cited by this paper
• Neural basis for hand muscle synergies in the primate spinal cord

  2017cited by this paper
• Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds

  2017cited by this paper
• Observed Brain Dynamics

  2016cited by this paper
• The human motor neuron pools receive a dominant slow‐varying common synaptic input

  2016cited by this paper
• Motor Neuron Pools of Synergistic Thigh Muscles Share Most of Their Synaptic Input

  2015cited by this paper
• Risk-Aware Control

  2014cited by this paper
• A category-free neural population supports evolving demands during decision-making

  2014cited by this paper
• Braided multi-electrode probes: mechanical compliance characteristics and recordings from spinal cords

  2013influential reference
• Distributed Control of Uncertain Systems Using Superpositions of Linear Operators

  2011cited by this paper
• Preferred locomotor phase of activity of lumbar interneurons during air-stepping in subchronic spinal cats.

  2011cited by this paper
• Population spatiotemporal dynamics of spinal intermediate zone interneurons during air-stepping in adult spinal cats.

  2011cited by this paper
• Chronux: a platform for analyzing neural signals.

  2010cited by this paper
• Controlling Variability

  2010cited by this paper
• A Neural Basis for Motor Primitives in the Spinal Cord

  2010influential reference
• Organization of mammalian locomotor rhythm and pattern generation.

  2008cited by this paper
• Techniques for extracting single-trial activity patterns from large-scale neural recordings.

  2007cited by this paper
• Comparing effects in spike-triggered averages of rectified EMG across different behaviors.

  2007cited by this paper
• Spike-triggered neural characterization.

  2006cited by this paper
• Modular Premotor Drives and Unit Bursts as Primitives for Frog Motor Behaviors

  2004cited by this paper
• Maximum likelihood estimation of cascade point-process neural encoding models

  2004cited by this paper
• Maximum Likelihood Estimation of a Stochastic Integrate-and-Fire Neural Encoding Model

  2004cited by this paper
• Robust, automatic spike sorting using mixtures of multivariate t-distributions.

  2003cited by this paper
• Estimating a State-Space Model from Point Process Observations

  2003cited by this paper
• TITLE : ROBUST , AUTOMATIC SPIKE SORTING USING MIXTURES OF MULTIVARIATE t-DISTRIBUTIONS

  2002influential reference
• Motor-unit synchronization is not responsible for larger motor-unit forces in old adults.

  2000cited by this paper
• Rapid Correction of Aimed Movements by Summation of Force-Field Primitives

  2000cited by this paper
• Research article

  1999cited by this paper
• Response patterns and force relations of monkey spinal interneurons during active wrist movement.

  1998cited by this paper
• Multiple fragment statistical analysis of post-spike effects in spike-triggered averages of rectified EMG.

  1998cited by this paper
• Frequency‐dependent synaptic depression modifies postsynaptic firing probability in cats

  1998cited by this paper
• Positive force feedback control of muscles.

  1997cited by this paper
• Wipe and flexion reflexes of the frog. I. Kinematics and EMG patterns.

  1993cited by this paper
• Convergent force fields organized in the frog's spinal cord

  1993cited by this paper
• Wipe and flexion reflexes of the frog. II. Response to perturbations.

  1993cited by this paper
• Computations underlying the execution of movement: a biological perspective.

  1991cited by this paper
• Kinematic strategies and sensorimotor transformations in the wiping movements of frogs.

  1989cited by this paper
• Selective facilitation of different hand muscles by single corticospinal neurones in the conscious monkey.

  1986cited by this paper
• Comparable patterns of muscle facilitation evoked by individual corticomotoneuronal (CM) cells and by single intracortical microstimuli in primates: evidence for functional groups of CM cells.

  1985cited by this paper
• Postspike facilitation of forelimb muscle activity by primate corticomotoneuronal cells.

  1980cited by this paper
• Response of rubromotoneuronal cells identified by spike-triggered averaging of EMG activity in awake monkeys.

  1980cited by this paper
• MUSCLES ALIVE-THEIR FUNCTIONS REVEALED BY ELECTROMYOGRAPHY

  1976cited by this paper
• Stochastic properties of motoneuron activity and the effect of muscular length

  1975cited by this paper
• Spike triggered averaging for the measurement of single unit conduction velocities.

  1975cited by this paper
• Statistical Power Analysis for the Behavioral Sciences

  1969cited by this paper
• The variation in isometric tension with sarcomere length in vertebrate muscle fibres

  1966cited by this paper
• Excitability and inhibitability of motoneurons of different sizes.

  1965cited by this paper
• Presynaptic Inhibition induced by Muscle Stretch

  1964cited by this paper
• Beiträge zur Kenntnis der menschlichen Reflexe mit besonderer Berücksichtigung der elektrischen Erscheinungen

  year unknowncited by this paper

• No citing papers are available for this paper.