Histamine and TNF-α release by rat peritoneal mast cells stimulated with Trichomonas vaginalis

Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-α and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-α. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.

• Publication year

  2011

• Venue

  Parasite

• Publication date

  2011-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1051/parasite/2011181049PMID 21395205PMCID 3671398
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proinflammatory cytokine and nitric oxide production by human macrophages stimulated with Trichomonas vaginalis.

  2009cited by this paper
• Global epidemiology and control of Trichomonas vaginalis

  2008influential reference
• Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition.

  2007cited by this paper
• Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data

  2007cited by this paper
• New and emerging roles for mast cells in host defence.

  2007cited by this paper
• Trichomonas vaginalis and trichomoniasis in the Republic of Korea.

  2006cited by this paper
• Trichomonas vaginalis promotes apoptosis of human neutrophils by activating caspase‐3 and reducing Mcl‐1 expression

  2006cited by this paper
• Mast Cell-Associated TNF Promotes Dendritic Cell Migration1

  2006cited by this paper
• Sargassum hemiphyllum inhibits atopic allergic reaction via the regulation of inflammatory mediators.

  2005cited by this paper
• Mast Cell-Dependent Control of Giardia lamblia Infections in Mice

  2004cited by this paper
• IgE-Mediated Mast Cell Activation Induces Langerhans Cell Migration In Vivo1

  2004cited by this paper
• Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse.

  2004cited by this paper
• Immune response‐mediated pathology in human intestinal parasitic infection

  2003cited by this paper
• Mast cells disrupt epithelial barrier function during enteric nematode infection

  2003cited by this paper
• Trichomonas vaginalis is associated with pelvic inflammatory disease in women infected with human immunodeficiency virus.

  2002cited by this paper
• Human mast cells and basophils as sources of cytokines

  2000cited by this paper
• Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

  2000cited by this paper
• Role of TGF-beta 1 on the IgE-dependent anaphylaxis reaction.

  1999cited by this paper
• Mast cells: a unique and functional diversity

  1998cited by this paper
• Association between giardiasis and allergy.

  1998cited by this paper
• Trichomonas vaginalis Associated With Low Birth Weight and Preterm Delivery

  1997cited by this paper
• Allergen-induced histamine release in intact human skin in vivo assessed by skin microdialysis technique: characterization of factors influencing histamine releasability.

  1996cited by this paper
• Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

  1996cited by this paper
• A novel neutrophil-activating factor released by Trichomonas vaginalis

  1992cited by this paper
• Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses

  1991cited by this paper
• Clinical Manifestations of Urogenital Trichomoniasis in Women

  1990cited by this paper
• Association of mast cells with vaginal trichomoniasis in endocervical smears.

  1983cited by this paper
• Polymorphonuclear cell chemotaxis to secretions of pathogenic and nonpathogenic Trichomonas vaginalis.

  1982cited by this paper
• Immune response to Trichomonas vaginalis. I. Genetic regulation of IgE antibody response to T. vaginalis in mice.

  1982cited by this paper
• Cell association of complexes of chymase, heparin proteoglycan, and protein after degranulation by rat mast cells.

  1981cited by this paper
• [Mastocyte count in the vaginal wall in trichomonal colpitis].

  1978cited by this paper
• Native heparin from rat peritoneal mast cells.

  1977cited by this paper
• [Behavior of the common part of the uterus in guinea pigs following infection with T. vaginalis. I. Mast cells].

  1977cited by this paper
• Increased serum immunoglobulin E concentrations in venereal diseases.

  1976cited by this paper
• Benign Diseases of the Vulva and Vagina

  1970cited by this paper
• The Colposcopical Picture of Trichomonas Vaginitis

  1964cited by this paper
• THE VASCULAR PATTERN OF TRICHOMONAS VAGINALIS CERVICITIS.

  1963cited by this paper
• A method for the fluorometric assay of histamine in tissues.

  1959cited by this paper

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  2026cites this paper
• Retinoic Acid Regulates Allergic Inflammation via Limiting Mast Cell Activation

  2025cites this paper
• Inflammatory responses during trichomoniasis: The role of Toll‐like receptors and inflammasomes

  2023cites this paper
• Effects of 101BHG-D01, a novel M receptor antagonism, on allergic rhinitis in animal models and its mechanism.

  2023cites this paper
• Inflammatory response to Trichomonas vaginalis in the pathogenesis of prostatitis and benign prostatic hyperplasia

  2023cites this paper
• Trichomonas vaginalis excretory secretory proteins reduce semen quality and male fertility.

  2022cites this paper
• Mast cell tryptase‐PAR2 pathway in proliferation of prostatic stromal cells reacted with Trichomonas vaginalis

  2021cites this paper
• Anti-Inflammatory Effects of a Cordyceps sinensis Mycelium Culture Extract (Cs-4) on Rodent Models of Allergic Rhinitis and Asthma

  2020cites this paper
• Production of Inflammatory Cytokines and Nitric Oxide by Human Mast Cells Incubated with Toxoplasma gondii Lysate

  2019cites this paper
• Histamine and diabetic nephropathy: an up-to-date overview.

  2019cites this paper
• Prunus serrulata var. spontanea inhibits mast cell activation and mast cell-mediated anaphylaxis.

  2019cites this paper
• Trichomonas vaginalis Induces Production of Proinflammatory Cytokines in Mouse Macrophages Through Activation of MAPK and NF-κB Pathways Partially Mediated by TLR2

  2018cites this paper
• BLT1-mediated O-GlcNAcylation is required for NOX2-dependent migration, exocytotic degranulation and IL-8 release of human mast cell induced by Trichomonas vaginalis-secreted LTB4.

  2018cites this paper
• SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4

  2016cites this paper
• Proliferation of Prostate Stromal Cell Induced by Benign Prostatic Hyperplasia Epithelial Cell Stimulated With Trichomonas vaginalis via Crosstalk With Mast Cell

  2016cites this paper
• Effects of chelidonic acid, a secondary plant metabolite, on mast cell degranulation and adaptive immunity in rats.

  2016cites this paper
• Serum Levels of Prolactin and Complement Components (C3 and C4) in Women Infected with Trichomonas vaginalis

  2015cites this paper
• Activation of MAPK Is Required for ROS Generation and Exocytosis in HMC-1 Cells Induced by Trichomonas vaginalis-Derived Secretory Products

  2015cites this paper
• Prostatic Disease Associated with Trichomonas vaginalis

  2014cites this paper
• Mast Cells Modulate Acute Toxoplasmosis in Murine Models

  2013cites this paper
• Infection of Cattle With Cryptosporidium parvum

  2013cites this paper
• : Mast Cell Accumulation in Small Intestine Mucosa Cryptosporidium parvum Infection of Cattle

  2013cites this paper
• Involvement of mast cells in inflammation induced by Trichomonas vaginalis via crosstalk with vaginal epithelial cells

  2012cites this paper