Room-Temperature Photochemical Copper-Mediated Fluorination of Aryl Iodides.

This report describes a method for the photochemical Cu-mediated fluorination of aryl iodides with AgF via putative aryl radical (Ar•) intermediates. It involves irradiating an aryl iodide with UVB light (λmax = 313 nm) in the presence of a mixture of CuI and CuII salts and AgF. Under these conditions, fluorination proceeds at room temperature for substrates containing diverse substituents, including alkoxy and alkyl groups, ketones, esters, sulfonate esters, sulfonamides, and protected amines. This method has been translated to radiofluorination using a combination of K18F, K3PO4, and AgOTf.

• Publication year

  2024

• Venue

  Organic Letters

• Publication date

  2024-07-18

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.orglett.4c02227PMID 39024514PMCID PMC11316249
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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