Role of transcriptional termination in the regulation of mu mRNA expression in B lymphocytes.

The synthesis of mRNA for mu-chain of membrane vs secretory IgM in normal resting B lymphocytes is stringently regulated. Very minimal amounts of microseconds mRNA are produced until the cells are stimulated. We have found a strong correlation between the initiation of mu S mRNA production and an alteration in the site of termination of polymerases transcribing the mu-gene. Furthermore, since the abundance of mu S mRNA is dependent on the differentiation stage of the B lymphocyte, we examined subpopulations of cells at various stages of activation and found that along with increased initiation of polymerases at the mu-locus, termination is moved further upstream in more highly differentiated cells. Therefore regulation of mu S mRNA may require factor(s) that induce transcriptional termination and these may be related to the factor(s) that augment transcriptional initiation.

• Publication year

  1989

• Venue

  Journal of Immunology

• Publication date

  1989-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.143.3.1046PMID 2501386
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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