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Structural Classification Insights Into the Plant Defensive Peptides

I. Setyawati,Ahmad Fadhlullah Husaini,Aprijal Ghiyas Setiawan,I. Artika,L. Ambarsari,W. Nurcholis,K. Vidilaseris,P. A. Kurniatin

Published 2024 in Proteins: Structure, Function, and Bioinformatics

ABSTRACT

This study presents a structural phylogenetic analysis of plant defensive peptides, revealing their evolutionary relationships, structural diversification, and functional adaptations. Utilizing a robust dataset comprising both experimental and predicted structures sourced from the RCSB Protein Data Bank and AlphaFold DB, we constructed a detailed phylogenetic tree to elucidate the distinct evolutionary paths of plant defensive peptide families. Our findings showcase the evolutionary intricacies of defensive peptides, highlighting their diversity and the conservation of key structural motifs critical to their antimicrobial or defensive functions. The results also underscore the adaptive significance of defensive peptides in plant evolution, highlighting their roles in responding to ecological pressures and pathogen interactions.

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