Phytochemical screening along with in vitro antioxidant, antibacterial and anticancer activity of Senna auriculata (L.) bark extracts

ABSTRACT This study aimed to evaluate the phytochemical content and biological properties of Senna auriculata (L.) Roxb. Four extracts—acetone, methanol, ethanol, and chloroform—were tested for antioxidant potential, enzymatic activity (peroxidase and polyphenol oxidase), antimicrobial, and anticancer effects. GC-MS analysis identified 34 bioactive compounds. The acetone extract exhibited the highest total alkaloid (5.8%), phenolic (752.78 ± 2.25 mg GAE/g), and flavonoid (285.78 ± 1.25 mg QE/g) content, along with the highest antioxidant (1489.42 ± 4.35 mg AAE/g) and enzyme activities. All extracts inhibited both Gram-positive and negative bacteria, with the acetone extract showing superior inhibition against S. aureus and B. subtilis. Additionally, the acetone and methanol extracts demonstrated anticancer effects on MDA-MB-231 breast cancer cells. These findings suggest that Senna auriculata has potential as a therapeutic agent for various diseases.

• Publication year

  2024

• Venue

  International Journal of Environmental Health Research

• Publication date

  2024-08-27

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1080/09603123.2024.2395446PMID 39189785
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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