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An Inhalable Nanoshield for Effective Prevention of Influenza Virus Infections.

Jing Li,Xue-Hui Shi,Dandan Fu,Lei Du,Bo Tang,Jian Ao,Ai-Xin Ma,Yi-Ning Hou,Zhi-Gang Wang,Shu-Lin Liu,Dai-Wen Pang

Published 2024 in ACS Nano

ABSTRACT

Influenza virus (IV) infection currently poses a serious and continuing threat to the global public health. Developing effective prevention strategies is important to defend against infection and spread of IV. Here, we developed a triple-protective nanoshield against IV infection in the lungs, formed by self-assembling DSPE-PEG amphiphilic polymers encapsulating the flu-preventive antiviral drug Arbidol internally. The preventive effect of the nanoshield against virus infection includes increasing the viscosity in the surrounding environment to physically defend against viral entry, forming a hydrated layer to block the interaction between viruses and cells, and inhibiting virus replication. Our finding suggested that a single inhalation of the nanoshield provides effective protection against IV infection for at least 8 h. Thus, this nanoshield may be a potential pandemic protection agent against IV, especially in viral environments, where no prophylactic or therapeutic measures are available.

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