In Vivo Evaluation of The Hepatotoxic Disorders of Tributyltin Low Doses in Male Rats

Tributyltin (TBT) has been used widely for over 60 years as a pesticidal, preservation, rodent repellent, water-repellant coating, corrosion inhibitor, flame-resistant polyester, and household product. Previous research has demonstrated the toxicity of high doses of TBT, but there is insufficient data on the effects of relevant levels of TBT on at low doses. The main goal of this thesis is to recognize the hepatotoxicity of Sublethal doses of TBT chloride (10-2000 µg/Kg body weight) in male rats for 45 days. TBT induced hepatic induction of oxidative stress as indicated by increasing levels of TBARS and 8-OHdG, induction of hepatic inflammation as indicated by the elevated NF-B levels; inhibition of hepatic expression of PGC-1α and impairment of mitochondrial biogenesis, induction of SREBP-1c and induce hepatic lipogenesis and fatty liver, and distortion of hepatic structure at histological level in a dose-dependent manner significantly at doses higher than 250 µg/kg. In conclusion: the TBT at low doses can induce hepatotoxicity at different levels.

• Publication year

  2024

• Venue

  Wasit Journal for Pure sciences

• Publication date

  2024-09-30

• Fields of study

  Not labeled

• Identifiers
  DOI 10.31185/wjps.497
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• The effects of TPT and dietary quercetin on growth, hepatic oxidative damage and apoptosis in zebrafish.

  2021cited by this paper
• Effects of chronic exposure to environmental levels of tributyltin on the lined seahorse (Hippocampus erectus) liver: Analysis of bioaccumulation, antioxidant defense, and immune gene expression.

  2021cited by this paper
• Transcriptomic effects of tributyltin (TBT) in zebrafish eleutheroembryos. A functional benchmark dose analysis.

  2020cited by this paper
• Relation of tributyltin and triphenyltin equilibrium sorption and kinetic accumulation in carp and Ceratophyllum demersum.

  2020cited by this paper
• Are antifouling residues a matter of concern in the largest South American port?

  2020cited by this paper
• Tributyltin triggers lipogenesis in macrophages via modifying PPARγ pathway.

  2020influential reference
• Spatiotemporal distribution of organotin compounds in the coastal water of the Bahía Blanca estuary (Argentina)

  2019cited by this paper
• Long-term triphenyltin exposure disrupts adrenal function in adult male rats.

  2019influential reference
• Impact of chronic exposure to trichlorfon on intestinal barrier, oxidative stress, inflammatory response and intestinal microbiome in common carp (Cyprinus carpio L.).

  2019cited by this paper
• Frontiers in endocrine disruption: Impacts of organotin on the hypothalamus-pituitary-thyroid axis.

  2018cited by this paper
• Effect of tributyltin on antioxidant ability and immune responses of zebrafish (Danio rerio).

  2017cited by this paper
• Tributyltin promoted hepatic steatosis in zebrafish (Danio rerio) and the molecular pathogenesis involved.

  2016cited by this paper
• Toxicogenomic analysis identifies the apoptotic pathway as the main cause of hepatotoxicity induced by tributyltin.

  2016cited by this paper
• Tributyltin chloride induced testicular toxicity by JNK and p38 activation, redox imbalance and cell death in sertoli-germ cell co-culture.

  2013cited by this paper
• Cell signalling by reactive lipid species: new concepts and molecular mechanisms

  2012cited by this paper
• Tributyltin causes obesity and hepatic steatosis in male mice

  2011influential reference
• The partition behavior of tributyltin and prediction of environmental fate, persistence and toxicity in aquatic environments.

  2009cited by this paper
• Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. a review. b_antizar@hotmail.com.

  2008cited by this paper
• Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

  2006cited by this paper
• Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling.

  2006cited by this paper
• Tributyltin induces DNA damage as well as oxidative damage in rats

  2006cited by this paper
• In vitro metabolism of tributyltin and triphenyltin by human cytochrome P-450 isoforms.

  2006cited by this paper
• T Cell Deficiency Leads to Liver Carcinogenesis in Azoxymethane-Treated Rats

  2006cited by this paper
• Reduction in oxidative stress and modulation of heart failure subsequent to myocardial infarction in rats.

  2005cited by this paper
• Organotin Compounds: Toxicokinetic Aspects

  2004cited by this paper
• DNA damage responses to oxidative stress.

  2004cited by this paper
• Calcium, ATP, and ROS: a mitochondrial love-hate triangle.

  2004cited by this paper
• Daily intake of TBT, Cu, Zn, Cd and As for fishermen in Taiwan.

  2002cited by this paper
• Butyltin compounds in Portuguese wines.

  2002cited by this paper
• Evaluation of tributyltin subchronic effects in tropical freshwater fish (Astyanax bimaculatus, Linnaeus, 1758).

  2002cited by this paper
• Reactive oxygen species, antioxidants, and the mammalian thioredoxin system.

  2001cited by this paper
• SPSS 13.0 Guide to Data Analysis

  2000cited by this paper
• Oxyradicals and DNA damage.

  2000cited by this paper
• Indirect mutagenesis by oxidative DNA damage: formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal.

  1998cited by this paper
• P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

  1996cited by this paper
• Oxidative stress and liver disease.

  1996cited by this paper
• The influence ofin vivo exposure to tributyltin on reactive oxygen formation in oyster toadfish macrophages

  1990cited by this paper
• Possible mutagens derived from lipids and lipid precursors.

  1990cited by this paper
• Radiation vs Chemical Damage to DNA

  1987cited by this paper
• Toxicity of bis(tri-n-butyltin)oxide in the rat. I. Short-term effects on general parameters and on the endocrine and lymphoid systems.

  1984cited by this paper
• Comparative organotin toxicity in the developing rat: somatic and morphological changes and relationship to accumulation of total tin.

  1982cited by this paper
• Inhibition of lipide peroxidation in mitochondria by vitamin E

  1959cited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• No citing papers are available for this paper.