Hypoxia regulate developmental coronary angiogenesis potentially through VEGF‐R2‐ and SOX17‐mediated signaling

The development of coronary vessels in embryonic mouse heart involves various progenitor populations, including sinus venosus (SV), endocardium, and proepicardium. ELA/APJ signaling is known to regulate coronary growth from the SV, whereas VEGF‐A/VEGF‐R2 signaling controls growth from the endocardium. Previous studies suggest hypoxia might regulate coronary growth, but its specific downstream pathways are unclear. In this study, we further investigated the role of hypoxia and have identified SOX17‐ and VEGF‐R2‐mediated signaling as the potential downstream pathways in its regulation of developmental coronary angiogenesis.

• Publication year

  2024

• Venue

  Developmental Dynamics

• Publication date

  2024-10-03

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1002/dvdy.750PMID 39360476PMCID PMC11810610
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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