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Effects of Increased Storage Period of Erythrocyte Suspensions on Patient Outcomes in Pediatric Patient Population Undergoing Craniosynostosis Surgery

A. Saraçoğlu

Published 2024 in Southern Clinics of Istanbul Eurasia

ABSTRACT

Objective: Although the blood transfusion required due to bleeding caused by the large incision area during craniosynostosis surgery is necessary to maintain the oxygen-carrying capacity of the blood, it carries significant risks. Our aim in this study is to determine the effect of the storage period of erythrocyte suspensions (ESs) on patient outcomes in the postoperative period in a pediatric patient group who underwent craniosynostosis surgery. Methods: Fifty-six patients aged 2-24 months who had undergone craniosynostosis surgery between 2018 and 2021 were included in our retrospective study. The patients were divided into two groups according to whether the storage time of the given ES and fresh frozen plasma (FFP) (time elapsed from the day it was received from the donor to the day it was transfused into the patients) was less or more than 10 days. Demographic data of the patients, mean arterial blood pressure, body temperature, hemoglobin (Hb), INR, platelet (plt) values, intraoperative bleeding, amount of transfusion, amount of crystalloid and colloid fluid administered, duration of operation, duration of anesthesia, complications, duration of stay in the postoperative intensive care unit (ICU), amount of transfusion given by drainage, and length of hospital stay were recorded. Results: The mean age of the patients was 8.27±6.294 months. A positive correlation was found between the storage time of ESs used in the intraoperative period, ES and crystalloid amount, and postoperative drainage. A negative correlation was found between intraoperative FFP transfusion and the change in Hb values measured in the ICU, and between intraoperative ES transfusion and plt values on ICU discharge (p<0.05). Conclusion: Our study concluded that the shortening of the storage time of ESs and FFPs may have a positive effect on postoperative drainage. However, since it was found to have no effect on hospital and ICU stay, it is thought that larger-scale studies are needed. ABSTRACT

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