Toll-Like Receptor 4 Activation in Microvascular Endothelial Cells Triggers a Robust Inflammatory Response and Cross Talk With Mononuclear Cells via Interleukin-6

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  2012-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/ATVBAHA.112.251181PMID 22596222PMCID PMC3384534
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IL-6 Increases MMP-13 Expression and Motility in Human Chondrosarcoma Cells*

  2011cited by this paper
• The role of chemokines and their receptors in angiogenesis

  2011cited by this paper
• Inflammation in atherosclerosis: transition from theory to practice.

  2010cited by this paper
• IL‐6 and high glucose synergistically upregulate MMP‐1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c‐Jun

  2010cited by this paper
• Combinatorial interference of toll-like receptor 2 and 4 synergistically stabilizes atherosclerotic plaque in apolipoprotein E-knockout mice

  2010cited by this paper
• Activation of TLR2 and TLR4 by minimally modified low-density lipoprotein in human macrophages and monocytes triggers the inflammatory response.

  2010cited by this paper
• Treating atherosclerosis: the potential of Toll-like receptors as therapeutic targets

  2010cited by this paper
• Contrast-enhanced ultrasound imaging detects intraplaque neovascularization in an experimental model of atherosclerosis.

  2010cited by this paper
• Invariant natural killer T cells: Linking inflammation and neovascularization in human atherosclerosis

  2010cited by this paper
• Toll-like receptors and type 1 diabetes.

  2010cited by this paper
• Innate immunity and the pathogenesis of type 1 diabetes

  2010cited by this paper
• Differential analyses of angiogenesis and expression of growth factors in micro- and macrovascular endothelial cells of type 2 diabetic rats.

  2009influential reference
• Interleukin-6 Released from Fibroblasts Is Essential for Up-regulation of Matrix Metalloproteinase-1 Expression by U937 Macrophages in Coculture

  2009cited by this paper
• Botulinum Toxin in Cerebral Child Palsy

  2009cited by this paper
• Chlamydia Pneumoniae and Atherosclerosis: Current State and Future Prospectives

  2009cited by this paper
• IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.

  2009cited by this paper
• Increased Neovascularization in Advanced Lipid-Rich Atherosclerotic Lesions Detected by Gadofluorine-M–Enhanced MRI: Implications for Plaque Vulnerability

  2009cited by this paper
• Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases

  2009cited by this paper
• Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

  2008cited by this paper
• Inflammatory angiogenesis in atherogenesis—a double-edged sword

  2008cited by this paper
• Local expression of Toll-like receptor 4 at the site of ruptured plaques in patients with acute myocardial infarction

  2008cited by this paper
• Lipopolysaccharides from atherosclerosis‐associated bacteria antagonize TLR4, induce formation of TLR2/1/CD36 complexes in lipid rafts and trigger TLR2‐induced inflammatory responses in human vascular endothelial cells

  2007cited by this paper
• This information is current as Inflammation Adaptive Immunity , Coagulation , and Endothelial Cells : Directing Innate and Immune Regulation by Microvascular

  2007cited by this paper
• Porphyromonas gingivalis mediated periodontal disease and atherosclerosis: disparate diseases with commonalities in pathogenesis through TLRs.

  2007cited by this paper
• Evolving functions of endothelial cells in inflammation

  2007cited by this paper
• Neovascularization in human atherosclerosis.

  2006cited by this paper
• Angiogenesis in atherosclerosis: gathering evidence beyond speculation

  2006cited by this paper
• Toll-like receptor signaling and atherosclerosis

  2006cited by this paper
• Endotoxin, TLR4 signaling and vascular inflammation: potential therapeutic targets in cardiovascular disease.

  2006influential reference
• Hydraulic conductance of pulmonary microvascular and macrovascular endothelial cell monolayers.

  2006cited by this paper
• Active participation of endothelial cells in inflammation

  2005cited by this paper
• Endothelial cells in inflammation and angiogenesis.

  2005cited by this paper
• Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension.

  2005cited by this paper
• Method for large scale isolation, culture and cryopreservation of human monocytes suitable for chemotaxis, cellular adhesion assays, macrophage and dendritic cell differentiation.

  2004cited by this paper
• Plaque Neovascularization Is Increased in Ruptured Atherosclerotic Lesions of Human Aorta: Implications for Plaque Vulnerability

  2004cited by this paper
• Potential role of endotoxin as a proinflammatory mediator of atherosclerosis.

  2004cited by this paper
• Minimally Modified LDL Binds to CD14, Induces Macrophage Spreading via TLR4/MD-2, and Inhibits Phagocytosis of Apoptotic Cells*

  2003cited by this paper
• Vulnerable atherosclerotic plaque: clinical implications.

  2003cited by this paper
• Integration of vascular biology and magnetic resonance imaging in the understanding of atherothrombosis and acute coronary syndromes

  2003cited by this paper
• Inflammation and immune responses in atherosclerosis.

  2002cited by this paper
• Intimomedial Interface Damage and Adventitial Inflammation Is Increased Beneath Disrupted Atherosclerosis in the Aorta: Implications for Plaque Vulnerability

  2002cited by this paper
• Epidemiologic association of Chlamydia pneumoniae and atherosclerosis: the initial serologic observation and more.

  2000cited by this paper
• What an interventional cardiologist should know about the pathophysiology of acute myocardial infarction.

  1999cited by this paper
• Leucocyte recruitment in rupture prone regions of lipid-rich plaques: a prominent role for neovascularization?

  1999cited by this paper
• Pulmonary microvascular and macrovascular endothelial cells: differential regulation of Ca2+and permeability.

  1998cited by this paper
• Pulmonary microvascular and macrovascular endothelial cells: differential regulation of Ca2+ and permeability.

  1998cited by this paper
• Human microvascular endothelial cells differ from macrovascular endothelial cells in their expression of matrix metalloproteinases.

  1997cited by this paper
• Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content.

  1996cited by this paper
• Immunohistochemical study of intimal microvessels in coronary atherosclerosis.

  1993cited by this paper
• Vascular cell adhesion molecule-1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis.

  1993cited by this paper
• Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

  1976cited by this paper

• Lactiplantibacillus plantarum BGI-N6 mitigates obesity-linked inflammation and oxidative stress via gut microbiota-mediated metabolites.

  2026cites this paper
• SARS-CoV-2 mRNA vaccines: unresolved mechanisms of myocardial damage.

  2025cites this paper
• Sympathetic regulation of the host immune response to bacterial sepsis

  2025cites this paper
• Integrative in vitro and in silico evaluation of HSP60-derived peptides as immunomodulators of the TLR4/MD-2 complex

  2025cites this paper
• Chronic Pod-Mod E-Cigarette Aerosol Exposure Induces Aortic Dysfunction in Hypercholesterolemic Mice: Role of Oxidative Stress and Inflammation.

  2025cites this paper
• Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis

  2025cites this paper
• Pathways regulating the release of tissue factor-positive extracellular vesicles and activation of coagulation in endotoxemic mice.

  2025cites this paper
• Analyzing IL-2-induced vascular leakage with an irAOP as tool

  2024cites this paper
• Physiologie de la réponse endothéliale microvasculaire en situation d’inflammation aiguë

  2024cites this paper
• Excessive hypercholesterolaemia during pregnancy as a risk factor for endothelial dysfunction in pre-eclampsia.

  2024cites this paper
• Endothelial TLR4 Activation by Endogenous Ligands Contributes to Small Blood Vessels Formation in Angiolipoma

  2024cites this paper
• The influence of sex on neuroimmune communication, pain, and physiology

  2024cites this paper
• Comparative and Temporal Characterization of LPS and Blue-Light-Induced TLR4 Signal Transduction and Gene Expression in Optogenetically Manipulated Endothelial Cells

  2023cites this paper
• The Impacts of Animal-Based Diets in Cardiovascular Disease Development: A Cellular and Physiological Overview

  2023cites this paper
• Inflammation and neutrophil extracellular traps in cerebral cavernous malformation

  2022cites this paper
• MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and secondary brain edema in a mouse model of intracerebral hemorrhage

  2022cites this paper
• MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhage

  2022cites this paper
• Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis

  2022cites this paper
• A Vicious Cycle: In Severe and Critically Ill COVID-19 Patients

  2022cites this paper
• The Yin and Yang of toll-like receptors in endothelial dysfunction.

  2022cites this paper
• Hematopoiesis, Inflammation and Aging—The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals

  2022cites this paper
• Lung histopathological findings in COVID-19 disease – a systematic review

  2021influential citation
• Heme stimulates platelet mitochondrial oxidant production to induce targeted granule secretion.

  2021cites this paper
• Multi-Pharmacology of Berberine in Atherosclerosis and Metabolic Diseases: Potential Contribution of Gut Microbiota

  2021cites this paper
• Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs

  2021cites this paper
• LPS-enriched small extracellular vesicles from metabolic syndrome patients trigger endothelial dysfunction by activation of TLR4.

  2021cites this paper
• Crosstalk of TLR4, vascular NADPH oxidase, and COVID-19 in diabetes: What are the potential implications?

  2021cites this paper
• The Roles of Nitric Oxide Synthase/Nitric Oxide Pathway in the Pathology of Vascular Dementia and Related Therapeutic Approaches

  2021cites this paper
• Myeloid Differentiation Factor 2 in the Heart: Bench to bedside evidence for potential clinical benefits?

  2020cites this paper
• Toll-Like Receptor 4 Signaling in Focal Cerebral Ischemia: a Focus on the Neurovascular Unit

  2020cites this paper
• When Innate Immunity Meets Angiogenesis—The Role of Toll-Like Receptors in Endothelial Cells and Pulmonary Hypertension

  2020cites this paper
• IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

  2020cites this paper
• Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity.

  2020cites this paper
• Berberine treatment increases Akkermansia in the gut and improves high-fat diet-induced atherosclerosis in Apoe-/- mice.

  2018cites this paper
• ADAM17-Mediated Ectodomain Shedding of Toll-Like Receptor 4 as a Negative Feedback Regulation in Lipopolysaccharide-Activated Aortic Endothelial Cells

  2018cites this paper
• Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4

  2018cites this paper
• TLR4 in Atherogenesis: Paying the Toll for Antimicrobial Defense.

  2018cites this paper
• Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway

  2017cites this paper
• The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease

  2016cites this paper
• Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1β Secondarily to Activation of C5 and CD14 in Whole Blood

  2016cites this paper
• Modulation of endothelial function by Toll like receptors.

  2016cites this paper
• GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS.

  2015cites this paper
• Sulfiredoxin-1 protects primary cultured astrocytes from ischemia-induced damage.

  2015cites this paper
• Berberine protects vascular endothelial cells in hypertensive rats.

  2015cites this paper
• Shear Stress Modulates Resistin‐Induced CC Chemokine Ligand 19 Expression in Human Aortic Endothelial Cells

  2015cites this paper
• High glucose induces and activates Toll-like receptor 4 in endothelial cells of diabetic retinopathy

  2015cites this paper
• Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability

  2015cites this paper
• Expression of Toll-like receptors in human retinal and choroidal vascular endothelial cells.

  2015cites this paper
• Toll‐like receptors: Role in inflammation and therapeutic potential

  2014influential citation
• Endothelial cells but not platelets are the major source of Toll-like receptor 4 in the arterial thrombosis and tissue factor expression in mice.

  2014influential citation
• Innate immunity in atherosclerosis : the role of pattern recognition receptors

  2014cites this paper
• Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of statins.

  2014cites this paper
• Toll-Like Receptor 4 Mediates Endothelial Cell Activation Through NF-κB but Is Not Associated with Endothelial Dysfunction in Patients with Rheumatoid Arthritis

  2014cites this paper
• Lipopolysaccharide Induces Endoplasmic Store Ca2+-Dependent Inflammatory Responses in Lung Microvessels

  2013cites this paper
• NF-κB pathway is involved in CRP-induced effects on pulmonary arterial endothelial cells in chronic thromboembolic pulmonary hypertension.

  2013cites this paper
• Marked Independent Relationship between Circulating Interleukin-6 Concentrations and Endothelial Activation in Rheumatoid Arthritis

  2013cites this paper
• Artificial extracellular matrices composed of collagen I and high sulfated hyaluronan modulate monocyte to macrophage differentiation under conditions of sterile inflammation

  2012cites this paper
• Hyperglycemia induces Toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy.

  2012cites this paper
• Retinol-Binding Protein 4 Induces Inflammation in Human Endothelial Cells by an NADPH Oxidase- and Nuclear Factor Kappa B-Dependent and Retinol-Independent Mechanism

  2012cites this paper
• Hyperglycemia induced Toll like receptor 4 Expression and Activity in Mouse Mesangial

  2012cites this paper