Severe Radiation-Induced Brachial Plexopathy: A Case Report on Radiation Toxicity in a Patient With Invasive Ductal Carcinoma

The ataxia-telangiectasia mutated (ATM) gene is an important regulator of cell checkpoint signaling and the repair of double-stranded breaks. When the ATM gene is mutated or damaged, cells are less capable of responding to damage induced by radiation therapy (RT). Here, we present a case of a 50-year-old woman with stage IIIA invasive ductal carcinoma of the left breast who had genetic testing revealing pathogenic ATM mutations (c.5290del and c.4396C>G) and a PALB2 mutation (c.1619dup). While guidelines suggest that adjuvant radiation therapy is safe for patients with ATM mutations, this patient experienced severe radiation-induced toxicities, including brachial plexopathy. These ATM mutations have not previously been described as imparting severe radiation-associated toxicities.

• Publication year

  2024

• Venue

  Cureus

• Publication date

  2024-11-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.7759/cureus.73043PMID 39640102PMCID 11618962
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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