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Urinary Proteome Characterization of Stroke-Prone Spontaneously Hypertensive Rats

Wenshu Meng,Youhe Gao

Published 2024 in bioRxiv

ABSTRACT

Background Hypertension is a multifactorial, complex disease related to genetic and environmental factors and has become the most serious public health problem. This study aimed to explore the changes of hypertension based on urinary proteome. Methods The stroke-prone spontaneously hypertensive rats (SHRSPs) model was used to examined urinary proteome changes during hypertension development. Urine proteome at months 1, 4, 8, 10, 12, and 14 was profiled using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Considered the degree of disease progression may differ, each rat was compared before and after hypertension developed to screen for differential proteins. Results The differential proteins in each rat can be enriched into some important biological processes and pathways associated with hypertension, such as regulation of systemic arterial blood pressure by renin-angiotensin, renin-angiotensin signaling, response to glucocorticoid and glucocorticoid receptor signaling, calcium transport I, aldosterone adipocyte signaling pathway, apelin adipocyte signaling pathway and oxidative stress response. The biological processes and pathways enriched at the same time point in the progression of hypertension differed significantly among different rat individuals. Conclusions This study showed that the changes of hypertension can be reflected in urine proteins. The urine proteomics has the potential to be used to study the mechanisms of hypertension, discovery new drug targets, and provide personalized antihypertensive treatment strategies.

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