Elevated tau in the piriform cortex in Alzheimer's but not Parkinson's disease using PET‐MR

Olfactory dysfunction can be an early sign of Alzheimer's disease (AD). We used tau positron emission tomography‐magnetic resonance (PET‐MR) to analyze a key region of the olfactory circuit, the piriform cortex, in comparison to the adjacent medial temporal lobe.

• Publication year

  2024

• Venue

  Alzheimer's & Dementia

• Publication date

  2024-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/dad2.70040PMID 39583648PMCID 11585164
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Association of APOE ε4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults

  2023cited by this paper
• Automatic and manual segmentation of the piriform cortex: Method development and validation in patients with temporal lobe epilepsy and Alzheimer's disease

  2023cited by this paper
• Odor Discrimination as a Marker of Early Alzheimer’s Disease

  2023cited by this paper
• Volumetric analysis of the piriform cortex in temporal lobe epilepsy

  2022cited by this paper
• Olfaction, Cognitive Impairment, and PET Biomarkers in Community-Dwelling Older Adults

  2022cited by this paper
• Noradrenergic Modulation of the Piriform Cortex: A Possible Avenue for Understanding Pre-Clinical Alzheimer’s Disease Pathogenesis

  2022cited by this paper
• Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease

  2021cited by this paper
• Hippocampal subfield imaging and fractional anisotropy show parallel changes in Alzheimer's disease tau progression using simultaneous tau‐PET/MRI at 3T

  2021cited by this paper
• Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases

  2020cited by this paper
• Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

  2020cited by this paper
• COVID-19-induced anosmia associated with olfactory bulb atrophy

  2020cited by this paper
• Olfactory Dysfunction Predicts Disease Progression in Parkinson’s Disease: A Longitudinal Study

  2020cited by this paper
• Approximating anatomically-guided PET reconstruction in image space using a convolutional neural network

  2020cited by this paper
• Perturbation of in vivo Neural Activity Following α-Synuclein Seeding in the Olfactory Bulb

  2020cited by this paper
• Amyloid-β and Tau at the Crossroads of Alzheimer's Disease.

  2019cited by this paper
• Association of Piriform Cortex Resection With Surgical Outcomes in Patients With Temporal Lobe Epilepsy.

  2019cited by this paper
• A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

  2019cited by this paper
• Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

  2019cited by this paper
• Tau PET imaging with 18F-PI-2620 in Patients with Alzheimer Disease and Healthy Controls: A First-in-Humans Study

  2019cited by this paper
• Alzheimer's disease.

  2019cited by this paper
• Odorant Item Specific Olfactory Identification Deficit May Differentiate Alzheimer Disease From Aging.

  2018cited by this paper
• High‐resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas

  2017cited by this paper
• Olfactory Dysfunction as an Early Biomarker in Parkinson’s Disease

  2017cited by this paper
• Position paper on olfactory dysfunction.

  2017cited by this paper
• Central Olfactory Dysfunction in Alzheimer’s Disease and Mild Cognitive Impairment: A Functional MRI Study

  2017cited by this paper
• Ensemble Classification of Alzheimer's Disease and Mild Cognitive Impairment Based on Complex Graph Measures from Diffusion Tensor Images

  2017cited by this paper
• Apo E4 Alleles and Impaired Olfaction as Predictors of Alzheimer’s Disease

  2017cited by this paper
• Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia.

  2016cited by this paper
• Comprehensive cellular‐resolution atlas of the adult human brain

  2016cited by this paper
• The effects of intracranial volume adjustment approaches on multiple regional MRI volumes in healthy aging and Alzheimer's disease

  2014cited by this paper
• Global image registration using a symmetric block-matching approach

  2014cited by this paper
• The Olfactory System

  2014cited by this paper
• The Piriform Cortex and Human Focal Epilepsy

  2014cited by this paper
• Interneurons, tau and amyloid-β in the piriform cortex in Alzheimer’s disease

  2014cited by this paper
• A brief olfactory test for Alzheimer's disease.

  2013cited by this paper
• The relevance of the Lewy Body to the pathogenesis of idiopathic Parkinson's disease

  2012cited by this paper
• Disruption of odour quality coding in piriform cortex mediates olfactory deficits in Alzheimer's disease.

  2010cited by this paper
• Olfactory Impairment in Presymptomatic Alzheimer's Disease

  2009cited by this paper
• A comparative study of odor identification and odor discrimination deficits in Parkinson's disease

  2008cited by this paper
• Olfactory identification and incidence of mild cognitive impairment in older age.

  2007cited by this paper
• User-guided 3D active contour segmentation of anatomical structures: Significantly improved efficiency and reliability

  2006cited by this paper
• Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

  2006cited by this paper
• MR volumetric analysis of the piriform cortex and cortical amygdala in drug-refractory temporal lobe epilepsy.

  2005cited by this paper
• Potential legal nightmare. Simple case, complex resolution.

  2005cited by this paper
• Projections from the amygdaloid complex to the piriform cortex: A PHA‐L study in the rat

  2004cited by this paper
• Idiopathic hyposmia as a preclinical sign of Parkinson's disease

  2004cited by this paper
• Neuropathological stageing of Alzheimer-related changes

  2004cited by this paper
• Staging of brain pathology related to sporadic Parkinson's disease.

  2003cited by this paper
• Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)

  2002cited by this paper
• Handbook of olfaction and gustation

  1996cited by this paper
• The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

  1988cited by this paper

• Olfactory deprivation promotes amyloid β deposition in a mouse model of Alzheimer's disease.

  2025cites this paper
• Alterations in Olfactory Cortex Volume in Mild Cognitive Impairment and Mild Alzheimer’s Disease Dementia: A Study of Sex-Related Differences

  2025cites this paper
• Segmentation-Guided Development of Visual Classification Criteria for Alzheimer’s Disease

  2025cites this paper
• Selective reduction of KCNA4 in vulnerable glutamatergic-serotonin neurons of the dorsal raphe nucleus in Alzheimer’s Disease

  2025cites this paper
• Trajectory of olfactory cortex degeneration from normal cognition to Alzheimer's disease: Insights from multimodal neuroimaging.

  2025cites this paper