去泛素化酶OTUD3的研究进展

去泛素化酶含OTU结构域蛋白3(OTU domain-containing protein 3，OTUD3)是非常重要的去泛素化酶，在多种疾病模型中存在明显的表达差异。在不同细胞中，OTUD3参与调控凋亡、炎症反应、细胞周期、增殖和侵袭等生物学功能。OTUD3通过调节多种关键底物蛋白的去泛素化，在先天性抗病毒免疫、神经发育、神经系统退行性疾病、肿瘤等生理和病理过程中发挥重要作用。OTUD3在乳腺癌、食管癌、结肠癌、甲状腺乳头状癌中发挥抑癌作用，但在肝癌和肺癌中发挥促癌作用。作为恶性肿瘤的生物标志物，OTUD3在预测、诊断和判断预后方面起重要作用。OTUD3在大部分疾病中的相关分子机制研究仍不够深入，研究OTUD3的调控机制对于深入了解其在免疫和疾病中的作用至关重要，以OTUD3为靶标的药物研发将是今后的研究重点。

• Publication year

  2024

• Venue

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

• Publication date

  2024-08-28

• Fields of study

  Not labeled

• Identifiers
  DOI 10.11817/j.issn.1672-7347.2024.230581PMID 39788523PMCID 11628234
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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