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Disagreement on foundational principles of biological aging

V. Gladyshev,Benjamin Anderson,Hanna Barlit,Benjamin Barré,Samuel Beck,Bahareh Behrouz,D. Belsky,A. Chaix,M. Chamoli,Brian Chen,Kaiyang Cheng,Jane Chuprin,Gary A. Churchill,Andrea Cipriano,A. Colville,J. Deelen,Yuri Deigin,KeHuan K Edmonds,Brad English,Ruogu Fang,Michael Florea,Iosif M. Gershteyn,Diljeet Gill,Laura H. Goetz aa,V. Gorbunova,Patrick T. Griffin,Steve Horvath,Ma Xin,J. Ae,Sara Jovanovska af,ah Kathrin M. Kajderowicz ag,Tomoko Kasahara,C. Kerepesi,S. Kulkarni,Vyacheslav M. Labunskyy,Morgan Ac,Sergiy Libert al,J. Yuyang,Yuancheng Ryan Lu,R. Lu,R. Marioni,Brianah M. McCoy,Wayne Mitchell,M. Moqri,Nasirian ao,Peter Niimi,H. Oh,Brian Okundaye ap,Andrey A. Parkhitko aq,Leonid Peshkin ar,Mia Petljak,J. Poganik,G. Pridham,D. Au,Weronika Prusisz av,Margaux Quiniou aw,K. Raj,Daniel Richard,J. Luis,Ricon ay,J. Rutledge,Morten Scheibye-Knudsen az,N. Ba,A. Seluanov,M. Shadpour,Anastasia V. Shindyapina ay,Steven R. Shuken,S. Sivakumar,Thomas Stoeger,Ayumu Sugiura bf,Nadia R. Sutton,A. Suvorov,Andrei E. Tarkhov ay,Emma Bi,Alexandre Trapp,A. Tyshkovskiy,M. Unfried,C. Ward‐Caviness,Sun Hee Yim,Kejun Ying,Jeffrey M. Yunes,Bohan Zhang,A. Zhavoronkov,Patrick Stover

Published 2024 in PNAS Nexus

ABSTRACT

Abstract To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion—even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as “aging” by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field.

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